- View all variations as list
CODE | Dosage Strength | Drug Packaging | Availability | Price | ||
---|---|---|---|---|---|---|
XELEVIA-HMAD21
|
In stock
|
₱3950 | ||||
XELEVIA-6YLPTY
|
In stock
|
₱3850 |
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Features
- Sitagliptin
Description
Indications/Uses
Combination Therapy: Peroxisome proliferator-activated receptor γ (PPAR-γ) agonist (eg, thiazolidinediones) or metformin as initial therapy or when the single agent alone, with diet and exercise does not improve adequate glycemic control.
Combination with a sulfonylurea in patient with type 2 DM to improve glycemic control when treatment with single agent alone, with diet and exercise, does not provide ad equate glycemic control.
Combination with metformin and sulfonylurea, metformin and PPAR-γ agonists (thiazolidinediones) when dual therapy with these agents, does not provide adequate glycemic control.
Combination with insulin as adjunct to diet and exercise to improve glycemic control in combination with insulin (with or without metformin).
Dosage/Direction for Use
Patients with Moderate Renal Insufficiency [Creatinine Clearance (CrCl) ≥30 to <50 mL/min, Approximately Corresponding to Serum Creatinine Levels of >1.7 to <3 mg/dL in Men and >1.5 to ≤2.5 mg/dL in Women]: 50 mg once daily.
Severe Renal Insufficiency CrCl <30 mL/min, Approximately Corresponding to Serum Creatinine Level of 3 mg/dL in Men and >2.5 mg/dL in Women or End-Stage Renal Disease (ESRD) Requiring Hemodialysis or Peritoneal Dialysis: 25 mg once daily. Maybe administered without regards to the timing of hemodialysis. Because there is a dosage adjustment based upon renal function, assessment of renal function is recommended prior to initiation and periodically, thereafter.
Administration
Contraindications
Special Precautions
For patients with mild renal insufficiency (CrCl ≥50 mL/min, approximately corresponding to serum creatinine levels of ≤1.7 mg/dL in men and ≤1.5 mg/dL in women), no dosage adjustment for Xelevia is required.
Use in pregnancy & lactation: Use with caution in pregnancy and lactation.
Use in children: Use with caution in children <18 years.
Use in the elderly: Should be used with caution in the elderly.