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Features
- Paracetamol
Description
Indications/Uses
Dosage/Direction for Use
Overdosage
Serious toxicity or fatalities have been extremely infrequent following acute paracetamol overdose in young children, possibly because of differences in the way children metabolize paracetamol. In children, the maximum potential amount ingested can be more easily estimated. If >150 mg/kg or if an unknown amount of paracetamol was ingested, obtain a plasma paracetamol level as soon as possible, but no sooner than 4 hrs following ingestion. If an assay cannot be obtained and the estimated paracetamol ingestion exceeds 150 mg/kg, dosing with N-acetylcysteine should be initiated and continued for a full course of therapy.
Administration
Contraindications
Repeated administration in patients with anemia, cardiac, pulmonary, renal and hepatic damage.
Special Precautions
Discontinue use and consult a doctor if: Symptoms do not improve, new symptoms occur, pain or fever persists or gets worse, or redness or swelling is present.
Do not exceed recommended dose. Keep out of reach of children. In case of accidental overdose, contact a physician or poison control center immediately. Prompt medical attention is critical for adults as well as for children even if signs or symptoms are not noticed.
Use in Pregnancy & Lactation: Paracetamol crosses the placenta but the drug has been widely used as an analgesic in pregnancy and no adverse fetal effects have been recorded. However, as with any drug, a doctor is to be consulted before using Biogesic if pregnant or breastfeeding.
Adverse Reactions
Drug Interactions
Storage
Action
Pharmacology: Mechanism of Action: Paracetamol exhibits analgesic and antipyretic activity by inhibiting prostaglandin synthesis. It produces analgesia by elevating the pain threshold and antipyresis through action on the hypothalamic heat-regulating center.
In therapeutic doses, paracetamol's analgesic and antipyretic action is comparable to that of aspirin. Paracetamol does not adversely affect platelet function and hemostasis.
Pharmacokinetics: Paracetamol is rapidly and completely absorbed after oral administration. Peak plasma concentrations occur between 15 min to 2 hrs after ingestion. The absolute oral bioavailability of paracetamol is about 80% and is independent of dose in the range of 5-20 mg/kg.
Paracetamol is not bound to plasma proteins to any extent. The concentrations of paracetamol in saliva are similar to those in plasma. Concentrations in whole blood are up to 20% higher and in breast milk about 20% lower than the plasma concentration. Paracetamol crosses the placenta.
Paracetamol is extensively metabolized in the liver and the total body clearance is about 5 mL/kg/min. The clearance of paracetamol is reduced and the half-life is increased following a hepatotoxic overdose. Prolongation beyond 4 hrs usually indicates impending liver damage.
Two to five percent of a therapeutic dose of paracetamol is excreted unchanged in the urine. Its renal clearance is about 10 mL/min and is weakly dependent on urine flow rate but not on pH.