CONZACE Multivitamins / Minerals Soft Gel Capsule 1's
NONRXDRUG-DR-XY33366-1pc
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| CODE | Dosage Strength | Drug Packaging | Availability | Price | ||
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NONRXDRUG-DR-XY33366-1pc
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In stock
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₱1400 |
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Features
Brand
Conzace
Full Details
Dosage Strength
Formulation: Each softgel capsule contains Retinol palmitate (Vit. A) dl-Alpha Tocopheryl Acetate (Vitar Ascorbic Acid (Vit. C) Zinc (as Sulfate) 5,000 IU 100 IU 500mg 25mg
Drug Ingredients
- Minerals
- Multivitamins
Drug Packaging
SoftGel Capsule 1's
Generic Name
Multivitamins / Minerals
Dosage Form
Softgel Capsule
Registration Number
DR-XY33366
Drug Classification
Over-The-Counter (OTC)
Description
Indications/Uses
A nutritional supplement, for 19 years old and above, for the prevention and treatment of vitamins and/or mineral deficiencies.
Dosage/Direction for Use
Orally, one softgel capsule once a day. Or, as directed by a doctor.
Missed Dose: If the patient missed the dose for the day, just take the next dose and the subsequent doses at the usual recommended schedule, i.e., once a day.
Do not double the dose unless recommended by a doctor.
Missed Dose: If the patient missed the dose for the day, just take the next dose and the subsequent doses at the usual recommended schedule, i.e., once a day.
Do not double the dose unless recommended by a doctor.
Overdosage
Signs and Symptoms of Overdosage: Vitamin A: Chronic daily vitamin A intakes in excess of 10,000 IU or weekly intakes in excess of 25,000 IU have resulted in hypervitaminosis A. Early signs of hypervitaminosis A include fatigue, lethargy (lack of energy), irritability, malaise/depression, loss of appetite, abdominal pain/discomfort, nausea and vomiting, mild fever, and excessive sweating. Treatment of hypervitaminosis A consists of discontinuance of vitamin A and supportive therapy as indicated.
Other symptoms of vitamin A toxicity include blurred or double vision, dizziness, drowsiness, headache, insomnia, lack of muscle coordination, seizures, papilledema, raised intracranial pressure; bulging fontanelle (in infants), hypercalcemia (due to increase in activity of alkaline phosphatase), bone and joint pain, rapid resorption of bone/hyperostosis, osteoporosis, osteosclerosis, skin disorders (dermatitis, dryness, pruritus/itching, redness, scaliness, skin peeling, rash), cracking of the lips, loss of hair, diarrhea, weight loss, cessation of menstruation in women, and liver damage, which in turn leads to jaundice.
Not all signs appear in all patients, and relative severity varies widely among different individuals. Most signs and symptoms disappear within a week, but skin and bone changes may remain evident for several months.
A long term study also suggests that high intake of vitamin A (≥2,000 mcg of retinol per day) is related to increased risk of hip fractures in older women.
Excessive vitamin A intake (more than 10,000 IU daily) is hazardous when taken during the first and second trimesters of pregnancy. Excessive vitamin A intake during pregnancy may lead to birth defects such as cleft palate, heart abnormalities and brain malformations, e.g., hydrocephalus and microcephaly (baby with a very small head).
Vitamin C: Prolonged intake of vitamin C (ascorbic acid) in excess of 2 g per day may lead to nausea, abdominal cramps, diarrhea, and nose bleeds. Elevated serum glucose levels, GI obstruction, and esophagitis have also been reported in those taking high oral doses of vitamin C. In people with kidney disease, excess vitamin C also may contribute to oxalate-containing kidney stones. In healthy people, epidemiological studies do not support an association between excess vitamin C intake and kidney stones. High vitamin C intake may also boost iron absorption - useful for some, but problematic for people with hemochromatosis, a metabolic disease that cause excess iron accumulation.
Vitamin E: There are no available data on acute overdosage with vitamin E. However, large doses have occasionally been associated with side effects (see Adverse Reactions).
Zinc: Signs of acute zinc toxicity (doses > 200 mg daily) include GI pain/cramps, nausea, vomiting, and diarrhea, loss of appetite, headache, lethargy, muscle pains, and fever.
Prolonged zinc supplementation may cause impairment of copper and iron status, and anemia at doses >50 mg/day; immune deficiency, reduced blood high-density lipoprotein (HDL) levels, and gastric erosion at doses > 150 mg daily.
Long-term (average 6.3 years) ingestion of supplemental zinc (80 mg/day) has also been linked to a significant increase in hospitalizations for urinary tract infections and kidney stones.
If the patient has taken more than the recommended dosage, consult a doctor.
Other symptoms of vitamin A toxicity include blurred or double vision, dizziness, drowsiness, headache, insomnia, lack of muscle coordination, seizures, papilledema, raised intracranial pressure; bulging fontanelle (in infants), hypercalcemia (due to increase in activity of alkaline phosphatase), bone and joint pain, rapid resorption of bone/hyperostosis, osteoporosis, osteosclerosis, skin disorders (dermatitis, dryness, pruritus/itching, redness, scaliness, skin peeling, rash), cracking of the lips, loss of hair, diarrhea, weight loss, cessation of menstruation in women, and liver damage, which in turn leads to jaundice.
Not all signs appear in all patients, and relative severity varies widely among different individuals. Most signs and symptoms disappear within a week, but skin and bone changes may remain evident for several months.
A long term study also suggests that high intake of vitamin A (≥2,000 mcg of retinol per day) is related to increased risk of hip fractures in older women.
Excessive vitamin A intake (more than 10,000 IU daily) is hazardous when taken during the first and second trimesters of pregnancy. Excessive vitamin A intake during pregnancy may lead to birth defects such as cleft palate, heart abnormalities and brain malformations, e.g., hydrocephalus and microcephaly (baby with a very small head).
Vitamin C: Prolonged intake of vitamin C (ascorbic acid) in excess of 2 g per day may lead to nausea, abdominal cramps, diarrhea, and nose bleeds. Elevated serum glucose levels, GI obstruction, and esophagitis have also been reported in those taking high oral doses of vitamin C. In people with kidney disease, excess vitamin C also may contribute to oxalate-containing kidney stones. In healthy people, epidemiological studies do not support an association between excess vitamin C intake and kidney stones. High vitamin C intake may also boost iron absorption - useful for some, but problematic for people with hemochromatosis, a metabolic disease that cause excess iron accumulation.
Vitamin E: There are no available data on acute overdosage with vitamin E. However, large doses have occasionally been associated with side effects (see Adverse Reactions).
Zinc: Signs of acute zinc toxicity (doses > 200 mg daily) include GI pain/cramps, nausea, vomiting, and diarrhea, loss of appetite, headache, lethargy, muscle pains, and fever.
Prolonged zinc supplementation may cause impairment of copper and iron status, and anemia at doses >50 mg/day; immune deficiency, reduced blood high-density lipoprotein (HDL) levels, and gastric erosion at doses > 150 mg daily.
Long-term (average 6.3 years) ingestion of supplemental zinc (80 mg/day) has also been linked to a significant increase in hospitalizations for urinary tract infections and kidney stones.
If the patient has taken more than the recommended dosage, consult a doctor.
Administration
May be taken with or without food: May be taken w/ meals for better absorption or if GI discomfort occurs.
Contraindications
If the patient is allergic to any ingredient in the product.
If the patient is pregnant or breastfeeding.
Vitamin A is contraindicated in patients who have hypervitaminosis A.
If the patient is pregnant or breastfeeding.
Vitamin A is contraindicated in patients who have hypervitaminosis A.
Special Precautions
Oral vitamin A preparations should not be used for treating vitamin A deficiency in persons with malabsorption syndromes.
Chronic consumption of vitamin A may cause liver damage.
Vitamin C should be used with caution in patients with renal failure (risk of oxalate stones); erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolytic anemia); hemochromatosis; sickle cell anemia (risk of precipitating a crisis); thalassemia; or sideroblastic anemia.
High doses of vitamin E (i.e., doses greater than 100 IU) should be used with caution in patients on warfarin. Monitoring of international normalized ratio (INR) and adjusting of warfarin dose (if indicated) are recommended. Likewise, those with vitamin K deficiencies, such as patients with liver failure, should be cautious in taking high doses of vitamin E.
Vitamin E should be used with extreme caution in those with any lesions that have a tendency to bleed (e.g., bleeding peptic ulcers), those with a history of hemorrhagic stroke, and those with inherited bleeding disorders (e.g., hemophilia).
Zinc should be used with caution in patients with kidney disease.
Do not use more than the recommended dose. If the patient is taking other supplements, read the label, since those supplements may contain the same ingredients as this product.
Consult the Doctor: If any undesirable effect occurs.
If the patient is pregnant or breastfeeding, consult a doctor before using this product.
Chronic consumption of vitamin A may cause liver damage.
Vitamin C should be used with caution in patients with renal failure (risk of oxalate stones); erythrocyte glucose-6-phosphate dehydrogenase (G6PD) deficiency (risk of hemolytic anemia); hemochromatosis; sickle cell anemia (risk of precipitating a crisis); thalassemia; or sideroblastic anemia.
High doses of vitamin E (i.e., doses greater than 100 IU) should be used with caution in patients on warfarin. Monitoring of international normalized ratio (INR) and adjusting of warfarin dose (if indicated) are recommended. Likewise, those with vitamin K deficiencies, such as patients with liver failure, should be cautious in taking high doses of vitamin E.
Vitamin E should be used with extreme caution in those with any lesions that have a tendency to bleed (e.g., bleeding peptic ulcers), those with a history of hemorrhagic stroke, and those with inherited bleeding disorders (e.g., hemophilia).
Zinc should be used with caution in patients with kidney disease.
Do not use more than the recommended dose. If the patient is taking other supplements, read the label, since those supplements may contain the same ingredients as this product.
Consult the Doctor: If any undesirable effect occurs.
If the patient is pregnant or breastfeeding, consult a doctor before using this product.
Use In Pregnancy & Lactation
Conzace is contraindicated if the patient is pregnant or breastfeeding.
Adverse Reactions
Undesirable effects may occur, particularly when the nutrients are used at high doses (e.g., concomitant use of other multivitamin-mineral supplements), see also Signs and Symptoms of Overdosage under Overdosage. In general, the amount of nutrients in this product is relatively nontoxic and is usually well tolerated.
Vitamin A: Skin and subcutaneous tissue disorders: Dermatitis, photosensitivity reactions.
Vitamin C: Blood and lymphatic system disorders: Hemolysis [after large oral doses of ascorbic acid in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency].
Immune system disorders: Delayed-type allergic response.
Psychiatric disorders: Insomnia, sleepiness.
Nervous system disorders: Headache.
Vascular disorders: Flushing.
Gastrointestinal disorders: Abdominal cramps, diarrhea (at a dose of 1 g or more daily), esophagitis (rare), flatulent distention, gastric discomfort, heartburn, intestinal obstruction (rare), nausea, transient colic, vomiting.
Renal and urinary disorders: Increased urination (mild), kidney stone formation (associated with large dosages of ascorbic acid reportedly have been limited to individuals with preexisting renal disease).
Injury, poisoning and procedural complications: Erosion of dental enamel.
Vitamin E: Endocrine disorders: Thyroid problems.
Nervous system disorders: Dizziness, headache.
Eye disorders: Blurred vision.
Vascular disorders: Hypertension, thrombophlebitis (vein inflammation related to a blood clot).
Gastrointestinal disorders: Nausea, diarrhea, abdominal pain/intestinal cramps.
Skin and subcutaneous tissue disorders: Rash.
Musculoskeletal and connective tissue disorders: Myopathy (pain or weakness in the muscles).
Reproductive system and breast disorders: Breast soreness/gynecomastia, gonadal dysfunction.
Investigations: Creatinuria (increased concentrations of creatine in the urine), increased serum creatine kinase, serum cholesterol, and triglycerides; increased urinary estrogens and androgens.
Doses of vitamin E greater than 1,000 mg (equivalent to 1,490 IU) daily for prolonged periods have occasionally been associated with increased bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants. It has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens.
Zinc: Doses of zinc up to 30 mg/day are generally well-tolerated.
Metabolism and nutrition disorders: Loss of appetite.
Psychiatric disorders: Drowsiness.
Nervous system disorders: Headache, metallic taste.
Gastrointestinal disorders: Abdominal pain/cramps, diarrhea, dyspepsia, gastritis, gastrointestinal discomfort/irritation, nausea, vomiting.
Vitamin A: Skin and subcutaneous tissue disorders: Dermatitis, photosensitivity reactions.
Vitamin C: Blood and lymphatic system disorders: Hemolysis [after large oral doses of ascorbic acid in patients with glucose-6-phosphate dehydrogenase (G6PD) deficiency].
Immune system disorders: Delayed-type allergic response.
Psychiatric disorders: Insomnia, sleepiness.
Nervous system disorders: Headache.
Vascular disorders: Flushing.
Gastrointestinal disorders: Abdominal cramps, diarrhea (at a dose of 1 g or more daily), esophagitis (rare), flatulent distention, gastric discomfort, heartburn, intestinal obstruction (rare), nausea, transient colic, vomiting.
Renal and urinary disorders: Increased urination (mild), kidney stone formation (associated with large dosages of ascorbic acid reportedly have been limited to individuals with preexisting renal disease).
Injury, poisoning and procedural complications: Erosion of dental enamel.
Vitamin E: Endocrine disorders: Thyroid problems.
Nervous system disorders: Dizziness, headache.
Eye disorders: Blurred vision.
Vascular disorders: Hypertension, thrombophlebitis (vein inflammation related to a blood clot).
Gastrointestinal disorders: Nausea, diarrhea, abdominal pain/intestinal cramps.
Skin and subcutaneous tissue disorders: Rash.
Musculoskeletal and connective tissue disorders: Myopathy (pain or weakness in the muscles).
Reproductive system and breast disorders: Breast soreness/gynecomastia, gonadal dysfunction.
Investigations: Creatinuria (increased concentrations of creatine in the urine), increased serum creatine kinase, serum cholesterol, and triglycerides; increased urinary estrogens and androgens.
Doses of vitamin E greater than 1,000 mg (equivalent to 1,490 IU) daily for prolonged periods have occasionally been associated with increased bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants. It has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens.
Zinc: Doses of zinc up to 30 mg/day are generally well-tolerated.
Metabolism and nutrition disorders: Loss of appetite.
Psychiatric disorders: Drowsiness.
Nervous system disorders: Headache, metallic taste.
Gastrointestinal disorders: Abdominal pain/cramps, diarrhea, dyspepsia, gastritis, gastrointestinal discomfort/irritation, nausea, vomiting.
Drug Interactions
Vitamin A: Anticoagulant (e.g., warfarin): Concomitant administration with large doses of vitamin A may lead to increased risk of bleeding.
Retinoid (e.g., etretinate, isotretinoin, tretinoin): Avoid concomitant use of retinoids and preparations containing vitamin A or its derivatives because of the potential for additive undesirable effects.
Minocycline: Concomitant administration may lead to increased risk of pseudomotor cerebri.
Statins: Prolonged statin treatment may increase serum vitamin A levels.
Vitamin C: Antacids: Increased risk of aluminum toxicity has been noted with concomitant use; therefore, it is not recommended, especially in patients with renal insufficiency.
Aspirin: Concomitant intake may lead to increased urinary excretion of ascorbic acid and decreased excretion of aspirin.
Disulfiram: Prolonged administration of large doses (1 g daily) of vitamin C may interfere with the alcohol-disulfiram reaction.
Fluphenazine: Concomitant administration with ascorbic acid resulted in decreased fluphenazine plasma level.
Mexiletine: Large doses (1 g daily) of ascorbic acid may accelerate excretion of mexiletine.
Paracetamol: Ascorbic acid increases the apparent half-life of paracetamol.
Oral contraceptives (containing estrogens): These may reduce blood levels of ascorbic acid; large doses (>1 g) of vitamin C may increase plasma estrogen levels (possibly converting low-dose oral contraceptive to high-dose oral contraceptive); possibly breakthrough bleeding associated with withdrawal of high-dose vitamin C.
Warfarin: Ascorbic acid has reportedly decreased the anticoagulant effect of warfarin.
Others: Acidification of the urine following ascorbic acid administration may result in altered excretion of other drugs.
Vitamin E: Anticoagulants: Vitamin E reportedly may have anti-vitamin K effects; concomitant intake of anticoagulants (e.g., warfarin) and vitamin E may result in hemorrhage (bleeding).
Antiplatelets: High doses of vitamin E may also potentiate the effects of antiplatelets (e.g., aspirin, clopidogrel, ticlopidine) and herbs with antithrombotic activity such as garlic and gingko.
Zinc: Antibiotics (cephalosporins, quinolones, tetracyclines): Zinc decreases the absorption of these antibiotics. Taking the antibiotic at least 2 hours before or 4 to 6 hours after taking zinc supplement minimizes this interaction.
Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Interference with Laboratory Tests: Vitamin C interferes with the results of the following laboratory tests: paracetamol, aspartate aminotransferase, bilirubin, carbamazepine, creatinine, glucose, lactate dehydrogenase, stool guaiac, theophylline, and uric acid.
Tell the doctor about other medicines the patient is taking including supplements and herbal products, and other caffeine-containing products.
Retinoid (e.g., etretinate, isotretinoin, tretinoin): Avoid concomitant use of retinoids and preparations containing vitamin A or its derivatives because of the potential for additive undesirable effects.
Minocycline: Concomitant administration may lead to increased risk of pseudomotor cerebri.
Statins: Prolonged statin treatment may increase serum vitamin A levels.
Vitamin C: Antacids: Increased risk of aluminum toxicity has been noted with concomitant use; therefore, it is not recommended, especially in patients with renal insufficiency.
Aspirin: Concomitant intake may lead to increased urinary excretion of ascorbic acid and decreased excretion of aspirin.
Disulfiram: Prolonged administration of large doses (1 g daily) of vitamin C may interfere with the alcohol-disulfiram reaction.
Fluphenazine: Concomitant administration with ascorbic acid resulted in decreased fluphenazine plasma level.
Mexiletine: Large doses (1 g daily) of ascorbic acid may accelerate excretion of mexiletine.
Paracetamol: Ascorbic acid increases the apparent half-life of paracetamol.
Oral contraceptives (containing estrogens): These may reduce blood levels of ascorbic acid; large doses (>1 g) of vitamin C may increase plasma estrogen levels (possibly converting low-dose oral contraceptive to high-dose oral contraceptive); possibly breakthrough bleeding associated with withdrawal of high-dose vitamin C.
Warfarin: Ascorbic acid has reportedly decreased the anticoagulant effect of warfarin.
Others: Acidification of the urine following ascorbic acid administration may result in altered excretion of other drugs.
Vitamin E: Anticoagulants: Vitamin E reportedly may have anti-vitamin K effects; concomitant intake of anticoagulants (e.g., warfarin) and vitamin E may result in hemorrhage (bleeding).
Antiplatelets: High doses of vitamin E may also potentiate the effects of antiplatelets (e.g., aspirin, clopidogrel, ticlopidine) and herbs with antithrombotic activity such as garlic and gingko.
Zinc: Antibiotics (cephalosporins, quinolones, tetracyclines): Zinc decreases the absorption of these antibiotics. Taking the antibiotic at least 2 hours before or 4 to 6 hours after taking zinc supplement minimizes this interaction.
Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Interference with Laboratory Tests: Vitamin C interferes with the results of the following laboratory tests: paracetamol, aspartate aminotransferase, bilirubin, carbamazepine, creatinine, glucose, lactate dehydrogenase, stool guaiac, theophylline, and uric acid.
Tell the doctor about other medicines the patient is taking including supplements and herbal products, and other caffeine-containing products.
Storage
Store at temperatures not exceeding 30°C.
Protect from heat, light and moisture.
Protect from heat, light and moisture.
Action
This nutritional supplement is formulated with vitamins A, C, E and zinc to help enhance the body's natural immune function and help improve body resistance against illness and infections. These nutrients are also known to help the body's antioxidant defense system against damaging free radicals. Dietary intake may not be enough to meet the daily requirements to protect the body from various diseases. Thus, dietary supplementation is important to consider. (See table.)
MedsGo Class
Vitamins &/or Minerals
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