CITXL Citicoline 500mg Film-Coated Tablet 1's
CITXL C-R3KTVZ
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Features
Brand
Citxl
Full Details
Dosage Strength
500 mg
Drug Ingredients
- Citicoline
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Citicoline Sodium
Dosage Form
Film-Coated Tablet
Registration Number
DRP-2971
Drug Classification
Prescription Drug (RX)
Description
Indications/Uses
Supplement used for the improvement of thinking, learning and memory in people suffering from Alzheimer's disease, dementia, head trauma, Parkinson's disease and glaucoma.
Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.
Also used in loss of consciousness due to brain damage, head injury or brain surgery and cerebral infarction, age-related memory problems and stroke.
Dosage/Direction for Use
Disturbance of Consciousness Due to Head Injury or Brain Surgery: 100-500 mg 1-2 times daily.
Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once a day for 2 consecutive weeks.
Psychologic or Neurologic Disorders: Disturbance of Consciousness in the Acute Stage of Cerebral Infarction: 1000 mg once a day for 2 consecutive weeks.
Administration
May be taken with or without food.
Contraindications
Patients hypersensitive to citicoline and any of the components of Citxl.
Special Precautions
In acute and emergency condition, citicoline should be administered in conjunction with intracranial pressure-relieving drugs or homostatic and treatment eg, hypothermy. If intracranial bleeding continues, high-dose citicoline (>500 mg concomitantly) should be avoided, since it may exaggerate blood flow in brain. In such case, small dose of citicoline (100-500 mg 2-3 times daily) may be needed.
Precaution should be given in patients with hypersensitivity.
For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection is recommended within 2 weeks after apoplectic stroke.
Use in pregnancy & lactation: Generally, citicoline is avoided in pregnancy & nursing mothers.
Precaution should be given in patients with hypersensitivity.
For patients with disturbance of consciousness in acute stage of cerebral infarction, start of citicoline injection is recommended within 2 weeks after apoplectic stroke.
Use in pregnancy & lactation: Generally, citicoline is avoided in pregnancy & nursing mothers.
Use In Pregnancy & Lactation
Generally, citicoline is avoided in pregnancy & nursing mothers.
Adverse Reactions
Hypersensitivity Reaction: Rash.
Psychoneurologic: Insomnia, headache, dizziness, convulsion.
Gastrointestinal: Nausea, anorexia.
Hepatic: Abnormal liver function in laboratory measurement.
Eyes: Diplopia.
Others: Flushing, transient blood pressure changes or malaise.
Psychoneurologic: Insomnia, headache, dizziness, convulsion.
Gastrointestinal: Nausea, anorexia.
Hepatic: Abnormal liver function in laboratory measurement.
Eyes: Diplopia.
Others: Flushing, transient blood pressure changes or malaise.
Drug Interactions
In combination with levodopa, citicoline can increase effects of levodopa.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacokinetics: Citicoline is a water-soluble compound with >90% bioavailability. It is metabolized in the gut wall and liver. The byproducts of exogenous citicoline formed by hydrolysis in the intestinal wall are choline and cytidine. Following absorption, choline and cytidine are dispersed throughout the body, enter systemic circulation for utilization in various biosynthetic pathways and cross the blood-brain barrier for re-synthesis into citicoline in the brain.
Citicoline elimination occurs mainly via respiratory and urinary excretion, in 2 phases mirroring the biphasic plasma peaks. The initial peak in plasma concentration is followed by a sharp decline, which then slows over the next 4-10 hrs. In the 2nd phase, an initially rapid decline after the 24-hr plasma peak is similarly followed by a slower elimination rate. The elimination t½ of citicoline is 56 hrs.
Oral administration of citicoline raises plasma levels of cytidine and choline in within 6-8 hrs. Prolonged administration for 42 and 90 days increases brain concentrations of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine, the 3 major phospholipids in brain cell membranes. At a dose of 500 mg/kg/day, phosphatidylcholine levels increased by 25%, phosphatidylethanolamine by 17% and phosphatidylserine by 42%.
Citicoline elimination occurs mainly via respiratory and urinary excretion, in 2 phases mirroring the biphasic plasma peaks. The initial peak in plasma concentration is followed by a sharp decline, which then slows over the next 4-10 hrs. In the 2nd phase, an initially rapid decline after the 24-hr plasma peak is similarly followed by a slower elimination rate. The elimination t½ of citicoline is 56 hrs.
Oral administration of citicoline raises plasma levels of cytidine and choline in within 6-8 hrs. Prolonged administration for 42 and 90 days increases brain concentrations of phosphatidylcholine, phosphatidylethanolamine and phosphatidylserine, the 3 major phospholipids in brain cell membranes. At a dose of 500 mg/kg/day, phosphatidylcholine levels increased by 25%, phosphatidylethanolamine by 17% and phosphatidylserine by 42%.
MedsGo Class
Nootropics & Neurotonics/Neurotrophics
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