HYOS HYOScine N-Butylbromide 10mg Film-Coated Tablet 1's
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Features
- Hyoscine N-Butylbromide
Description
Indications/Uses
For the relief of symptoms of irritable bowel syndrome (IBS).
Injection: For the symptomatic relief of: Gastrointestinal and genitourinary disorders characterized by smooth muscle spasm; Spasm and dyskinesia of the biliary system; Irritable bowel syndrome (IBS).
As an aid to produce smooth muscle relaxation prior to radiological or other diagnostic procedures where spasm may be a problem (e.g., gastroduodenal endoscopy.
Dosage/Direction for Use
![](https://medsgo.ph/images/Table%20Description/Hyos/Table1.png?1682373443099)
IM injections should be administered 10-15 minutes prior to radiological/diagnostic procedures. (See Table 2.)
![](https://medsgo.ph/images/Table%20Description/Hyos/Table2.png?1682373453723)
Administration
Special Precautions
Conditions characterized by tachycardia (including thyrotoxicosis, hyperthyroidism, cardiac insufficiency, cardiac surgery) since hyoscine-N-butylbromide may further increase the heart rate.
Patients with gastric ulcer, gastroesophageal reflux disease or hiatal hernia associated with reflux esophagitis.
Patients with autonomic neuropathy, partial obstructive uropathy and diarrhea.
Those with known or suspected GI infections such as Clostridium difficile-associated diarrhea and colitis, shigellosis and dysentery since the drug may decrease GI motility causing retention of the pathogenic organism or toxin.
Patients with mild to moderate ulcerative colitis to prevent paralytic ileus that may lead to toxic megacolon.
Patients with pyrexia since the drug may reduce sweating.
Patients should immediately consult their ophthalmologist if they experience a painful, red eye with loss of vision. This may be due to increased intraocular pressure produced by the anticholinergic effect of hyoscine-N-butylbromide.
Cases of anaphylaxis including episodes of shock have been reported after parenteral administration of hyoscine-N-butylbromide.
Adverse Reactions
Rarely, anaphylactic shock including fatal outcome, anaphylactoid reactions, dyspnea, skin reactions, and other hypersensitivity.
Other adverse events include increased ocular tension (especially in patients with angle-closure glaucoma), sedation, drowsiness, irritability, disorientation, hallucinations, decreased blood pressure, loss of taste, headache, nervousness, weakness, flushing, insomnia, urinary retention, dry mouth, nausea, vomiting, and bloated feeling.
Action
Pharmacology: Tablet: This product contains hyoscine-N-butylbromide, an antispasmodic which works by relaxing the smooth muscles found in the walls of the stomach, intestines and bile duct (gastrointestinal system) and the reproductive organs and urinary tract (genitourinary system). It reduces muscle contractions by preventing acetylcholine from acting on the muscle allowing the muscle to relax thus reducing painful spasms and cramps.
Injection: Hyoscine-N-butylbromide is a quaternary ammonium derivative of hyoscine. It relaxes the smooth muscles of the gastrointestinal, biliary and urinary tracts by blocking the action of acetylcholine. Hyoscine-N-butylbromide reduces the tone and peristalsis of smooth muscles in hollow organs with parasympathetic innervation. It has peripheral anticholinergic effects that are less pronounced and of shorter duration than those of atropine. It does not penetrate the blood-brain barrier contributing to its minimal central effects.
Pharmacokinetics: Bioavailability: Hyoscine-N-butylbromide is rapidly distributed into the tissues after intravenous administration. It is partially metabolized in the liver to inactive compounds. The terminal elimination half-life is approximately 5 hours.
Its main route of excretion is through the kidneys; total body clearance is 1.2 L/minute. The main metabolites found in the urine are poorly bound to muscarinic receptors. It is not known whether hyoscine-N-butylbromide is removed by peritoneal dialysis or hemodialysis.