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Indications/Uses
Monnax: As an antacid for the symptomatic relief of hyperacidity in general.
Monnax Plus: Symptomatic relief of hyperacidity associated w/ peptic ulcer, gastritis, esophagitis & dyspepsia. Antiflatulent to alleviate the symptoms of gassiness including post-op gas pain associated w/ hyperacidity. Adjunct to H2-blockers or proton pump inhibitors for rapid relief of ulcer symptoms.
Monnax Plus: Symptomatic relief of hyperacidity associated w/ peptic ulcer, gastritis, esophagitis & dyspepsia. Antiflatulent to alleviate the symptoms of gassiness including post-op gas pain associated w/ hyperacidity. Adjunct to H2-blockers or proton pump inhibitors for rapid relief of ulcer symptoms.
Dosage/Direction for Use
Two to four teaspoonfuls (10-20 mL) four times a day taken 20 minute to 1 hour after meals and at bedtime.
Overdosage
Reported symptoms of acute overdose with aluminium hydroxide and magnesium salts combination include diarrhea, abdominal pain, vomiting. Large doses of this product may trigger or aggravate intestinal obstruction and ileus in patients at risk.
Aluminium and magnesium are eliminated through urinary route; treatment of acute overdose consists of administration of IV Calcium Gluconate, rehydration and forced diuresis. In case of renal function deficiency, haemodialysis or peritoneal dialysis is necessary.
Aluminium and magnesium are eliminated through urinary route; treatment of acute overdose consists of administration of IV Calcium Gluconate, rehydration and forced diuresis. In case of renal function deficiency, haemodialysis or peritoneal dialysis is necessary.
Administration
Should be taken with food: Take 20 min-1 hr after meals & at bedtime.
Contraindications
It is contraindicated to the patients who is suffering from kidney failure.
Warnings
Do not take more than 16 teaspoonful (80 mL) in a 24-hour period or use the maximum dosage for more than two weeks. Do not use if patient has kidney disease except under the advise and supervision of a physician.
Special Precautions
Aluminum hydroxide may cause constipation due to its astringent action, this effect may be balanced by the cathartic effect of the magnesium salts. Aluminum hydroxide may lead to a phosphate depletion syndrome, particularly in patients on a low phosphate diet eg, malnutrition. Magnesium salts may cause central nervous depression in the presence of renal insufficiency and should be used with caution in patients with advance renal disease. In patients with renal impairment, plasma levels of both aluminum and magnesium increase. In these patients, a long-term exposure to high doses of aluminum and magnesium salts may lead to encephalopathy or worsen dialysis osteomalacia. The prolonged use of antacids in patients with renal failure should be avoided.
Use In Pregnancy & Lactation
Should not be used during pregnancy unless considered essential by the physician.
Adverse Reactions
May cause diarrhea or constipation.
Drug Interactions
Aluminium hydroxide may form complexes with certain drugs eg, tetracyclines, digoxin and vitamins, resulting in decreased absorption. This should be borne in mind when concomitant administration is considered.
Concomitant use with quinidines may increase the serum levels of quinidine and lead to quinidine overdosage.
Aluminium-containing antacids may prevent the proper absorption of H2-antagonists, atenolol, chloroquine, cyclines, diflunisal, digoxin, diphosphonates, ethambutol, fluoroquinolones, sodium fluorine, glucocorticoids, indomethacin, isoniazid, kayexalate, ketoconazole, lincosamides, metoprolol, neuroleptics, phenothiazines, penicillamine, propranolol, iron salts.
Staggering the administration times of the interacting drug and the antacid by at least 2 hrs (4 hrs for the fluoroquinolones) will often help avoid undesirable drug interactions.
Concomitant use with quinidines may increase the serum levels of quinidine and lead to quinidine overdosage.
Aluminium-containing antacids may prevent the proper absorption of H2-antagonists, atenolol, chloroquine, cyclines, diflunisal, digoxin, diphosphonates, ethambutol, fluoroquinolones, sodium fluorine, glucocorticoids, indomethacin, isoniazid, kayexalate, ketoconazole, lincosamides, metoprolol, neuroleptics, phenothiazines, penicillamine, propranolol, iron salts.
Staggering the administration times of the interacting drug and the antacid by at least 2 hrs (4 hrs for the fluoroquinolones) will often help avoid undesirable drug interactions.
Storage
Store at temperatures not exceeding 30°C. Once opened, use within 28 days of opening.
Action
Pharmacologic Classification: Antacids.
Pharmacology: Pharmacodynamic: Aluminum hydroxide is a slow-acting antacid and magnesium hydroxide is fast acting. The 2 are frequently combined in antacid mixtures. Aluminum hydroxide on its own is astringent and may cause constipation. This effect is balanced by the effect of magnesium hydroxide, which, in common with other magnesium salts, may cause diarrhea.
Pharmacokinetic: The absorption of aluminium and magnesium from antacids is small. Aluminum hydroxide is slowly converted to aluminium chloride in the stomach. Some absorption of soluble aluminium salts occur in the gastrointestinal tract with urinary excretion. Any absorbed magnesium is likewise excreted in the urine.
Pharmacology: Pharmacodynamic: Aluminum hydroxide is a slow-acting antacid and magnesium hydroxide is fast acting. The 2 are frequently combined in antacid mixtures. Aluminum hydroxide on its own is astringent and may cause constipation. This effect is balanced by the effect of magnesium hydroxide, which, in common with other magnesium salts, may cause diarrhea.
Pharmacokinetic: The absorption of aluminium and magnesium from antacids is small. Aluminum hydroxide is slowly converted to aluminium chloride in the stomach. Some absorption of soluble aluminium salts occur in the gastrointestinal tract with urinary excretion. Any absorbed magnesium is likewise excreted in the urine.
MedsGo Class
Antacids, Antireflux Agents & Antiulcerants
Features
Dosage
225 mg / 200 mg per 5 mL
Ingredients
- Aluminum
- Magnesium
Packaging
Suspension 120ml
Generic Name
Aluminum Hydroxide / Magnesium Hydroxide
Registration Number
DR-XY20789-B
Classification
Over-The-Counter (OTC)
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