Please sign in so that we can notify you about a reply
Indications/Uses
It is used as an antiemetic for the short-term treatment of nausea and vomiting of various etiologies. It is not considered suitable for chronic nausea and vomiting, nor for the routine prophylaxis of postoperative vomiting.
Domperidone is also used for its prokinetic actions in dyspepsia and has been tried in diabetic gastroparesis. It is given with paracetamol in the symptomatic treatment of migraine.
Domperidone is also used for its prokinetic actions in dyspepsia and has been tried in diabetic gastroparesis. It is given with paracetamol in the symptomatic treatment of migraine.
Dosage/Direction for Use
Nausea and Vomiting: Adult: 10 mg - 20 mg.
1 tablet 3-4 times a day.
Children: 250-500 mcg/kg body weight.
1 tablet 3-4 times a day.
Dyspepsia: 10 mg 1 tablet 3 times a day.
Migraine: 20 mg taken every 4 hrs. with combination of paracetamol.
Or as prescribed by a physician.
1 tablet 3-4 times a day.
Children: 250-500 mcg/kg body weight.
1 tablet 3-4 times a day.
Dyspepsia: 10 mg 1 tablet 3 times a day.
Migraine: 20 mg taken every 4 hrs. with combination of paracetamol.
Or as prescribed by a physician.
Administration
Should be taken on an empty stomach.
Special Precautions
Domperidone is not recommended for chronic use for the routine prophylaxis of postoperative nausea and vomiting.
Adverse Reactions
Plasma-prolactin concentrations may be increased, which may lead to galactorrhoea. There have been reports of reduced libido, and rashes and other allergic reactions. Domperidone does not readily cross the blood-brain barrier and the incidence of central effects such as extrapyramidal reactions or drowsiness may be lower than with metoclopramide; however, there have been reports of dystonic reactions.
Drug Interactions
Domperidone may antagonize the hypoprolactinaemic effect of drugs such as bromocriptine. In addition, the prokinetic effects of domperidone may alter the absorption of such drugs. Opioid analgesics and antimuscarinics may antagonize the prokinetic effects of domperidone.
Action
Pharmacologic classification: Propulsive.
Pharmacology: Domperidone is a dopamine antagonist with anti-emetic properties. It does not readily cross the blood-brain barrier. In domperidone users, especially in adults, extrapyramidal side effects are very rare, but domperidone promotes the release of prolactin from the pituitary. Its anti-emetic effect may be due to a combination of peripheral (gastrokinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood-brain barrier in the area postrema.
Pharmacokinetics: The systemic bioavailability of domperidone is only about 15% in fasting subjects given a dose by mouth, although this is increased when domperidone is given after food. The low bioavailability is thought to be due to first-pass hepatic and intestinal metabolism.
Domperidone is more than 90% bound to plasma proteins, and has a terminal elimination half-life of about 7.5 hours. It is chiefly cleared from the blood by extensive metabolism. About 30% of an oral dose is excreted in faeces over several days, about 10% as unchanged drug. It does not readily cross the blood-brain barrier.
Small amounts of domperidone are distributed into breast milk, reaching concentrations about one-quarter of those in maternal serum.
Pharmacology: Domperidone is a dopamine antagonist with anti-emetic properties. It does not readily cross the blood-brain barrier. In domperidone users, especially in adults, extrapyramidal side effects are very rare, but domperidone promotes the release of prolactin from the pituitary. Its anti-emetic effect may be due to a combination of peripheral (gastrokinetic) effects and antagonism of dopamine receptors in the chemoreceptor trigger zone, which lies outside the blood-brain barrier in the area postrema.
Pharmacokinetics: The systemic bioavailability of domperidone is only about 15% in fasting subjects given a dose by mouth, although this is increased when domperidone is given after food. The low bioavailability is thought to be due to first-pass hepatic and intestinal metabolism.
Domperidone is more than 90% bound to plasma proteins, and has a terminal elimination half-life of about 7.5 hours. It is chiefly cleared from the blood by extensive metabolism. About 30% of an oral dose is excreted in faeces over several days, about 10% as unchanged drug. It does not readily cross the blood-brain barrier.
Small amounts of domperidone are distributed into breast milk, reaching concentrations about one-quarter of those in maternal serum.
MedsGo Class
GIT Regulators, Antiflatulents & Anti-Inflammatories
Features
Brand
Domilium
Full Details
Dosage Strength
10mg
Drug Ingredients
- Domperidone
Drug Packaging
Tablet 100's
Generic Name
Domperidone
Dosage Form
Tablet
Registration Number
DRP-3360-01
Drug Classification
Over-The-Counter (OTC)