NEOZEP Phenylephrine Hydrochloride / Chlorphenamine Maleate 1mg / 0.8mg per mL Syrup (Oral Drops) 10mL
Indications/Uses
Dosage/Direction for Use
Syrup: see Table 1.
Do not double the dose.
Overdosage
Chlorphenamine maleate: Extreme sleepiness or prolonged drowsiness, agitation, weakness, irritability, hallucination, tachycardia, convulsion, coma.
Syrup: Paracetamol: Overdosage of paracetamol usually involves 4 phases with the following signs and symptoms: I. Eating disorder, nausea, vomiting, malaise, and excessive sweating.
II. Right upper abdominal pain or tenderness, liver enlargement which may be characterized by abdominal discomfort of "feeling full", elevated bilirubin and liver enzyme concentrations, prolongation of prothrombin time, and occasionally decreased urine output.
III. Eating disorder, nausea, vomiting, and malaise recur and signs of liver (e.g., jaundice) and possibly kidney failure.
IV. Recovery or progression to fatal complete liver failure.
If the patient has taken more than the recommended dosage, consult a doctor or contact a poison control center right away, even if the patient seems well because of the risk of delayed, serious damage. Quick medical attention is important for adults as well as for children even if the patient does not notice any signs or symptoms.
Administration
Contraindications
Syrup: If the patient has anemia, kidney or liver disease unless recommended by a doctor; If the patient is pregnant or breastfeeding.
Special Precautions
Syrup: Liver warning: This product contains Paracetamol. Severe liver damage may occur if: A child takes more than 5 doses in 24 hours, which is the maximum daily amount of Paracetamol; an adult takes more than 4 g of Paracetamol in 24 hours, which is the maximum daily amount; taken with other medicines containing Paracetamol (or Acetaminophen); an adult has 3 or more alcoholic drinks everyday while using these products.
Do not use with any other medicine containing Paracetamol (prescription or nonprescription). If the patient is not sure whether medicine contains Paracetamol, ask a doctor.
Ask a doctor before use if the patient has liver or kidney disease.
Ask a doctor before use if the patient is taking Warfarin, a blood thinning medicine.
Do not take more than the recommended dose.
Consult a doctor: Before taking this medication, tell the doctor if the patient has: High blood pressure or any type of heart problems, glaucoma, thyroid problems, diabetes, bladder problems or difficulty urinating. Syrup: Liver or kidney disease, an enlarged prostate.
Stop use and ask a doctor if: Fever gets worse or lasts more than 3 days, new symptoms occur.
Adverse Reactions
Chlorphenamine Maleate may cause sleepiness and drowsiness. Other undesirable effects include muscle weakness, gastrointestinal discomfort, nausea, vomiting, diarrhea or constipation, dryness of the mouth, nose, and throat, difficulty urinating, ringing in the ears, visual disturbance, blurred vision, insomnia/sleeplessness, tremor, nervousness, irritability, chest tightness, increased or decreased blood pressure, and headache.
Syrup: Paracetamol, when taken within the recommended dose and duration of treatment, has low incidence of side effects. Skin rashes, hypersensitivity reactions, changes in the number of white blood cells and platelets, and minor stomach and intestinal disturbances have been reported.
Drug Interactions
Concurrent administration with medicines for depression (e.g., Amitriptyline, Imipramine, Sertraline, Moclobemide, etc.) may result in hypertensive crisis (sudden, severe increase in blood pressure that can lead to stroke).
Taking an adrenergic-blocking agent (e.g., Phenothiazine drugs, Phentolamine, Propranolol, etc.) before the administration of this product may decrease the effect of phenylephrine.
Tell the doctor about other medicines the child is taking, especially other medicines for cough, cold, or allergy.
Syrup: The absorption of Paracetamol may be accelerated by metoclopramide or domperidone and absorption reduced by cholestyramine. Medicines which stimulate the enzymes responsible for the metabolic activation of Paracetamol such as medicines for convulsion (e.g., Phenobarbital, etc.) may increase susceptibility to the harmful effects to the liver.
Warfarin, a blood thinning medicine; an increase in the International Normalized Ratio (INR), which may serve as a sign of increased risk for bleeding, may be observed when using Paracetamol and warfarin at the same time. Paracetamol increases the anticoagulation effect of Warfarin.
Storage
Action
Phenylephrine HCl, a nasal decongestant, clears obstructed air passages and nasal sinuses due to congestion making breathing easier. It also reduces postnasal drip.
Chlorphenamine Maleate, an anti-allergy relieves symptoms such as runny nose, sneezing, and itchy, watery eyes.
Paracetamol is an effective fever reducer and pain reliever.
MedsGo Class
Features
- Chlorphenamine Maleate
- Phenylephrine