LIVERPRIME HD Silibinin / Phosphatidylcholine / Multivitamins / Zinc Capsule 1's
NONRXDRUG-DR-XY46040-1pc
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
This product is used: To help maintain liver health.
As an adjunct in the management (under proper medical supervision) of a variety of liver disorders, including: Acute and chronic viral hepatitis; Liver cirrhosis; Alcohol-related liver disease; Liver damage from certain drugs (i.e., phenothiazine and butyrophenone); Fatty liver [e.g., Nonalcoholic fatty liver disease (NAFLD) or Nonalcoholic steatohepatitis (NASH)].
As an adjunct in the management (under proper medical supervision) of a variety of liver disorders, including: Acute and chronic viral hepatitis; Liver cirrhosis; Alcohol-related liver disease; Liver damage from certain drugs (i.e., phenothiazine and butyrophenone); Fatty liver [e.g., Nonalcoholic fatty liver disease (NAFLD) or Nonalcoholic steatohepatitis (NASH)].
Dosage/Direction for Use
Direction for Use in Adults: Orally, 1 capsule once to three times a day.
Or, as directed by a doctor.
Missed Dose: If a dose is missed, just take the next dose and the subsequent doses at the usual recommended schedule.
Do not double the dose, unless recommended by a doctor.
Or, as directed by a doctor.
Missed Dose: If a dose is missed, just take the next dose and the subsequent doses at the usual recommended schedule.
Do not double the dose, unless recommended by a doctor.
Overdosage
Silibinin: Silibinin has generally been well tolerated in recommended doses for up to 6 years. At high doses, a laxative effect may occur.
Phosphatidylcholine: There is no reported acute or chronic toxicity from phosphatidylcholine. Daily intakes of up to 18 grams have been generally well tolerated.
Nicotinic Acid: In normal doses, nicotinic acid is not toxic, but chronic administration at doses of 3 g daily for periods greater than three months may cause adverse effects (see Adverse Reactions).
Zinc: Signs of acute zinc toxicity (doses > 200 mg daily) include GI pain/cramps, nausea, vomiting, diarrhea, loss of appetite, headache, lethargy, muscle pain, and fever.
Chronic zinc toxicity may cause impairment of copper and iron status, anemia, and immune deficiency. Some findings have linked chronic zinc toxicity to the development of atherosclerosis because of a lowering of blood HDL levels.
If taken more than the recommended dosage, consult a doctor.
Phosphatidylcholine: There is no reported acute or chronic toxicity from phosphatidylcholine. Daily intakes of up to 18 grams have been generally well tolerated.
Nicotinic Acid: In normal doses, nicotinic acid is not toxic, but chronic administration at doses of 3 g daily for periods greater than three months may cause adverse effects (see Adverse Reactions).
Zinc: Signs of acute zinc toxicity (doses > 200 mg daily) include GI pain/cramps, nausea, vomiting, diarrhea, loss of appetite, headache, lethargy, muscle pain, and fever.
Chronic zinc toxicity may cause impairment of copper and iron status, anemia, and immune deficiency. Some findings have linked chronic zinc toxicity to the development of atherosclerosis because of a lowering of blood HDL levels.
If taken more than the recommended dosage, consult a doctor.
Administration
May be taken with or without food.
Contraindications
If has allergy to any ingredient in the product.
Adverse Reactions
Silibinin-phosphatidylcholine: Silibinin-phosphatidylcholine is generally well tolerated in clinical studies, even by patients with compensated cirrhosis. Reported side effects are rare and include occasional gastrointestinal (GI) distress, dyspepsia/heartburn, nausea, itching, and transient headache.
Asymptomatic liver toxicity has been observed in clinical trials involving cancer patients, in whom hyperbilirubinemia (elevated levels of bilirubin in the blood) and increases in alanine aminotransferase (ALT, a liver enzyme) levels were observed; however, these effects were present only when very high dosages of silibinin-phosphatidylcholine (between 10 and 20 g/day) were used. At high dose, a laxative effect is possible because of increased bile secretion and bile flow.
Other adverse effects reported with silibinin (or milk thistle) include abdominal pain or discomfort, flatulence/gassiness, diarrhea, loss of appetite, dizziness, urticaria (hives), eczema, and allergic/hypersensitivity and anaphylactic reactions. Excessive fullness (GI discomfort) and increased salivation have occasionally been reported with the use of phosphatidylcholine.
Nicotinic Acid: Chronic administration at doses of 3 g daily for periods greater than three months may cause nausea, heartburn, headache, fatigue, sore throat, dry hair, dry skin, tightness of the face, hives, and blurred vision.
Large doses of nicotinic acid (3 to 9 g daily) may result in elevated liver function tests and liver damage, including jaundice, cholestatic hepatitis, and portal fibrosis.
Other undesirable effects reported with high dose nicotinic acid include dizziness, diarrhea, vomiting, moderate increase in gastric secretion and bile flow; abnormal prothrombin time, and hypoalbuminemia (low albumin levels in the blood).
Zinc: Doses of zinc up to 30 mg/day are generally well tolerated. Higher doses may cause adverse reactions including nausea, vomiting, diarrhea, GI discomfort, metallic taste, headache, and drowsiness. Daily ingestion of zinc can lower high-density lipoprotein (HDL) levels. Long-term (average 6.3 years) ingestion of supplemental zinc has been linked to a significant increase in hospitalizations for urinary tract infections and kidney stones.
Asymptomatic liver toxicity has been observed in clinical trials involving cancer patients, in whom hyperbilirubinemia (elevated levels of bilirubin in the blood) and increases in alanine aminotransferase (ALT, a liver enzyme) levels were observed; however, these effects were present only when very high dosages of silibinin-phosphatidylcholine (between 10 and 20 g/day) were used. At high dose, a laxative effect is possible because of increased bile secretion and bile flow.
Other adverse effects reported with silibinin (or milk thistle) include abdominal pain or discomfort, flatulence/gassiness, diarrhea, loss of appetite, dizziness, urticaria (hives), eczema, and allergic/hypersensitivity and anaphylactic reactions. Excessive fullness (GI discomfort) and increased salivation have occasionally been reported with the use of phosphatidylcholine.
Nicotinic Acid: Chronic administration at doses of 3 g daily for periods greater than three months may cause nausea, heartburn, headache, fatigue, sore throat, dry hair, dry skin, tightness of the face, hives, and blurred vision.
Large doses of nicotinic acid (3 to 9 g daily) may result in elevated liver function tests and liver damage, including jaundice, cholestatic hepatitis, and portal fibrosis.
Other undesirable effects reported with high dose nicotinic acid include dizziness, diarrhea, vomiting, moderate increase in gastric secretion and bile flow; abnormal prothrombin time, and hypoalbuminemia (low albumin levels in the blood).
Zinc: Doses of zinc up to 30 mg/day are generally well tolerated. Higher doses may cause adverse reactions including nausea, vomiting, diarrhea, GI discomfort, metallic taste, headache, and drowsiness. Daily ingestion of zinc can lower high-density lipoprotein (HDL) levels. Long-term (average 6.3 years) ingestion of supplemental zinc has been linked to a significant increase in hospitalizations for urinary tract infections and kidney stones.
Drug Interactions
Silibinin: Drugs metabolized by the cytochrome P450 system: Silibinin may increase the effect of drugs metabolized by the cytochrome P450 system (e.g., clopidogrel, erythromycin, fexofenadine, nifedipine, tamoxifen, and warfarin).
Hypoglycemic agents: Silibinin may decrease insulin requirements of diabetic patients with alcoholic liver cirrhosis. However, no studies suggest altered glucose metabolism in patients without liver disease. Dosage adjustment of hypoglycemic agents and monitoring of blood glucose levels may be required.
Metronidazole: When used concomitantly, silibinin may reduce the effect of metronidazole.
Oral Contraceptives: Silibinin may reduce the effectiveness of oral contraceptives.
Statins: Silibinin may have cholesterol-lowering effects in humans.
Nicotinic Acid: Carbamazepine: Nicotinic acid may decrease carbamazepine clearance.
Zinc: Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Penicillamine: Concomitant administration reduces zinc absorption.
Quinolones: Zinc decreases absorption of quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, ofloxacin). Zinc salts or vitamins containing zinc should be given 2 hours after or 6 hours before antibiotics.
Tetracycline: Concomitant administration results in decreased tetracycline effectiveness. Administer tetracycline at least 2 hours before or 3 hours after zinc.
Food: Concomitant intake of caffeine or tea and zinc reduces zinc absorption. Food containing high amounts of phosphorus, calcium (dairy), or phytates (e.g., bran, brown bread) may also reduce its absorption.
Tell the doctor about all the medicines you are taking, including other supplements and herbal products.
Hypoglycemic agents: Silibinin may decrease insulin requirements of diabetic patients with alcoholic liver cirrhosis. However, no studies suggest altered glucose metabolism in patients without liver disease. Dosage adjustment of hypoglycemic agents and monitoring of blood glucose levels may be required.
Metronidazole: When used concomitantly, silibinin may reduce the effect of metronidazole.
Oral Contraceptives: Silibinin may reduce the effectiveness of oral contraceptives.
Statins: Silibinin may have cholesterol-lowering effects in humans.
Nicotinic Acid: Carbamazepine: Nicotinic acid may decrease carbamazepine clearance.
Zinc: Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Penicillamine: Concomitant administration reduces zinc absorption.
Quinolones: Zinc decreases absorption of quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, ofloxacin). Zinc salts or vitamins containing zinc should be given 2 hours after or 6 hours before antibiotics.
Tetracycline: Concomitant administration results in decreased tetracycline effectiveness. Administer tetracycline at least 2 hours before or 3 hours after zinc.
Food: Concomitant intake of caffeine or tea and zinc reduces zinc absorption. Food containing high amounts of phosphorus, calcium (dairy), or phytates (e.g., bran, brown bread) may also reduce its absorption.
Tell the doctor about all the medicines you are taking, including other supplements and herbal products.
Storage
Store at temperatures not exceeding 30°C.
MedsGo Class
Cholagogues, Cholelitholytics & Hepatic Protectors / Vitamins &/or Minerals
Features
Brand
Liverprime HD
Full Details
Dosage Strength
Formulation Each Capsule contains: Silibinin - PhosphatidylCholine -240mg (contains Silibinin... 29.7 to 36.3% and PhosphatidylCholine ... 63.7 to 70.3%) Thiamine mononitrate (Vitamin B1)-6mg Riboflavin (Vitamin B2)-6mg Pyridoxine Hydrochloride (Vitamin B
Drug Ingredients
- Multivitamins
- Phospholipids
- Silybin
- Zinc
Drug Packaging
Capsule 1's
Generic Name
Multivitamins / Phospholipids / Silybin / Zinc
Dosage Form
Capsule
Registration Number
DR-XY46040
Drug Classification
Dietary supplements
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