LIVERPRIME HD Silibinin / Phosphatidylcholine / Multivitamins / Zinc Capsule 1's
Indications/Uses
As an adjunct in the management (under proper medical supervision) of a variety of liver disorders, including: Acute and chronic viral hepatitis; Liver cirrhosis; Alcohol-related liver disease; Liver damage from certain drugs (i.e., phenothiazine and butyrophenone); Fatty liver [e.g., Nonalcoholic fatty liver disease (NAFLD) or Nonalcoholic steatohepatitis (NASH)].
Dosage/Direction for Use
Or, as directed by a doctor.
Missed Dose: If a dose is missed, just take the next dose and the subsequent doses at the usual recommended schedule.
Do not double the dose, unless recommended by a doctor.
Overdosage
Phosphatidylcholine: There is no reported acute or chronic toxicity from phosphatidylcholine. Daily intakes of up to 18 grams have been generally well tolerated.
Nicotinic Acid: In normal doses, nicotinic acid is not toxic, but chronic administration at doses of 3 g daily for periods greater than three months may cause adverse effects (see Adverse Reactions).
Zinc: Signs of acute zinc toxicity (doses > 200 mg daily) include GI pain/cramps, nausea, vomiting, diarrhea, loss of appetite, headache, lethargy, muscle pain, and fever.
Chronic zinc toxicity may cause impairment of copper and iron status, anemia, and immune deficiency. Some findings have linked chronic zinc toxicity to the development of atherosclerosis because of a lowering of blood HDL levels.
If taken more than the recommended dosage, consult a doctor.
Administration
Contraindications
Adverse Reactions
Asymptomatic liver toxicity has been observed in clinical trials involving cancer patients, in whom hyperbilirubinemia (elevated levels of bilirubin in the blood) and increases in alanine aminotransferase (ALT, a liver enzyme) levels were observed; however, these effects were present only when very high dosages of silibinin-phosphatidylcholine (between 10 and 20 g/day) were used. At high dose, a laxative effect is possible because of increased bile secretion and bile flow.
Other adverse effects reported with silibinin (or milk thistle) include abdominal pain or discomfort, flatulence/gassiness, diarrhea, loss of appetite, dizziness, urticaria (hives), eczema, and allergic/hypersensitivity and anaphylactic reactions. Excessive fullness (GI discomfort) and increased salivation have occasionally been reported with the use of phosphatidylcholine.
Nicotinic Acid: Chronic administration at doses of 3 g daily for periods greater than three months may cause nausea, heartburn, headache, fatigue, sore throat, dry hair, dry skin, tightness of the face, hives, and blurred vision.
Large doses of nicotinic acid (3 to 9 g daily) may result in elevated liver function tests and liver damage, including jaundice, cholestatic hepatitis, and portal fibrosis.
Other undesirable effects reported with high dose nicotinic acid include dizziness, diarrhea, vomiting, moderate increase in gastric secretion and bile flow; abnormal prothrombin time, and hypoalbuminemia (low albumin levels in the blood).
Zinc: Doses of zinc up to 30 mg/day are generally well tolerated. Higher doses may cause adverse reactions including nausea, vomiting, diarrhea, GI discomfort, metallic taste, headache, and drowsiness. Daily ingestion of zinc can lower high-density lipoprotein (HDL) levels. Long-term (average 6.3 years) ingestion of supplemental zinc has been linked to a significant increase in hospitalizations for urinary tract infections and kidney stones.
Drug Interactions
Hypoglycemic agents: Silibinin may decrease insulin requirements of diabetic patients with alcoholic liver cirrhosis. However, no studies suggest altered glucose metabolism in patients without liver disease. Dosage adjustment of hypoglycemic agents and monitoring of blood glucose levels may be required.
Metronidazole: When used concomitantly, silibinin may reduce the effect of metronidazole.
Oral Contraceptives: Silibinin may reduce the effectiveness of oral contraceptives.
Statins: Silibinin may have cholesterol-lowering effects in humans.
Nicotinic Acid: Carbamazepine: Nicotinic acid may decrease carbamazepine clearance.
Zinc: Bisphosphonates (alendronate, etidronate, risedronate): Concomitant intake of a bisphosphonate and zinc may decrease the absorption of both the bisphosphonate and zinc.
Cholesterol medicines: Additive effects are possible with concomitant administration; use with caution.
Copper or iron: Concomitant administration with zinc inhibits the absorption of copper and iron. Administer zinc and copper or iron as far apart as possible.
Penicillamine: Concomitant administration reduces zinc absorption.
Quinolones: Zinc decreases absorption of quinolone antibiotics (e.g., ciprofloxacin, levofloxacin, ofloxacin). Zinc salts or vitamins containing zinc should be given 2 hours after or 6 hours before antibiotics.
Tetracycline: Concomitant administration results in decreased tetracycline effectiveness. Administer tetracycline at least 2 hours before or 3 hours after zinc.
Food: Concomitant intake of caffeine or tea and zinc reduces zinc absorption. Food containing high amounts of phosphorus, calcium (dairy), or phytates (e.g., bran, brown bread) may also reduce its absorption.
Tell the doctor about all the medicines you are taking, including other supplements and herbal products.
Storage
MedsGo Class
Features
- Multivitamins
- Phospholipids
- Silybin
- Zinc