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Indications/Uses
Used for the treatment and prevention of vitamin E deficiency.
Dosage/Direction for Use
1 capsule (400 IU) daily.
Or as prescribed by the physician.
Or as prescribed by the physician.
Administration
Should be taken with food.
Contraindications
Known hypersensitivity to the active substance or to any of the excipients.
Special Precautions
Large doses of dl-alpha tocopheryl acetate (Vitamin E) have been reported to increase bleeding tendency in vitamin K-deficient patients such as those taking oral anticoagulants.
However, it has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens. The clinical significance of these effects is not known. A higher incidence of necrotizing enterocolitis has been noted in premature infants weighing less than 1.5 kg treated with vitamin E.
However, it has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking estrogens. The clinical significance of these effects is not known. A higher incidence of necrotizing enterocolitis has been noted in premature infants weighing less than 1.5 kg treated with vitamin E.
Use In Pregnancy & Lactation
Pregnancy: There is no evidence of the safety of high doses of vitamin E in pregnancy nor is there evidence from animal work that it is free from hazard, therefore do not use in pregnancy especially in the first trimester.
Lactation: No sufficient information is available on excretion in breast milk, therefore it is not advisable to use during lactation.
Lactation: No sufficient information is available on excretion in breast milk, therefore it is not advisable to use during lactation.
Adverse Reactions
dl-alpha tocopheryl acetate (Vitamin E) is usually well tolerated. Large doses may cause diarrhea, abdominal pain and other gastrointestinal disturbances, blurred vision, dizziness, fatigue and weakness.
Drug Interactions
dl-alpha tocopheryl acetate (Vitamin E) may increase the risk of thrombosis in patients taking estrogens. Various drugs may interfere with the absorption of vitamin E including colestyramine, colestipol and orlistat. High doses of vitamin E may increase the effects of oral anticoagulants.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: dl-alpha tocopheryl acetate (Vitamin E) is known to exert an important physiological function as an antioxidant for fats, with a sparing action on vitamin A, carotenoids and on unsaturated fatty acids. Other work has demonstrated that vitamin E is connected with the maintenance of certain factors essential for the normal metabolic cycle.
Pharmacokinetics: Absorption of dl-alpha tocopheryl acetate (Vitamin E) from the gastrointestinal tract is dependent on the presence of bile and on normal pancreatic function. The amount of vitamin E absorbed varies widely between about 20% and 80% and appears to decrease as the dose is increased. It enters the blood via the chylomicrons in the lymph and is bound to beta lipoproteins. It is widely distributed to all tissues and stored in adipose tissue. Some vitamin E is metabolized in the liver to glucuronides of tocopheronic acid and its γ-lactone. Some is excreted in the urine but most of a dose is slowly excreted in the bile. Vitamin E appears in breast milk but is poorly transferred across the placenta.
Pharmacokinetics: Absorption of dl-alpha tocopheryl acetate (Vitamin E) from the gastrointestinal tract is dependent on the presence of bile and on normal pancreatic function. The amount of vitamin E absorbed varies widely between about 20% and 80% and appears to decrease as the dose is increased. It enters the blood via the chylomicrons in the lymph and is bound to beta lipoproteins. It is widely distributed to all tissues and stored in adipose tissue. Some vitamin E is metabolized in the liver to glucuronides of tocopheronic acid and its γ-lactone. Some is excreted in the urine but most of a dose is slowly excreted in the bile. Vitamin E appears in breast milk but is poorly transferred across the placenta.
MedsGo Class
Vitamins A, D & E
Features
Dosage
400 IU
Ingredients
- Vit. E
Packaging
SoftGel Capsule 1's
Generic Name
Vit. E
Classification
Over-The-Counter (OTC)
GTIN
4806031902650
Product Questions
Questions
