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Indications/Uses
dl-Alpha-Tocopheryl Acetate (Vitamin E) is used in the treatment and prevention of Vitamin E deficiency and also in neurological disorder.
For the correction of Vitamin E deficiency occurring in malabsorption disorders ie. cystic fibrosis, chronic cholestasis and abetalipoproteinaemia.
For the correction of Vitamin E deficiency occurring in malabsorption disorders ie. cystic fibrosis, chronic cholestasis and abetalipoproteinaemia.
Dosage/Direction for Use
200-400 IU daily.
Or as prescribed by Physician.
Or as prescribed by Physician.
Administration
Should be taken with food.
Contraindications
Known hypersensitivity to the active substance or to any of the excipients.
Special Precautions
Large doses of dl-Alpha-Tocopheryl Acetate (Vitamin E) have been reported to increase bleeding tendency in Vitamin-K deficient patients such as those taking oral anticoagulants.
However, it has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking oestrogens. The clinical significance of these effects is not known.
A higher incidence of necrotising enterocolitis has been noted in premature infants weighing less than 1.5 kg treated with Vitamin E.
Use in Pregnancy: There is no evidence of the safety of high doses of Vitamin E in pregnancy nor is there evidence from animal work that it is free from hazard, therefore do not use in pregnancy especially in the first trimester.
Use in Lactation: No information is available on excretion in breast milk, therefore it is advisable not to use during lactation.
However, it has also been suggested that it may increase the risk of thrombosis in some patients, such as those taking oestrogens. The clinical significance of these effects is not known.
A higher incidence of necrotising enterocolitis has been noted in premature infants weighing less than 1.5 kg treated with Vitamin E.
Use in Pregnancy: There is no evidence of the safety of high doses of Vitamin E in pregnancy nor is there evidence from animal work that it is free from hazard, therefore do not use in pregnancy especially in the first trimester.
Use in Lactation: No information is available on excretion in breast milk, therefore it is advisable not to use during lactation.
Use In Pregnancy & Lactation
Use in Pregnancy: There is no evidence of the safety of high doses of Vitamin E in pregnancy nor is there evidence from animal work that it is free from hazard, therefore do not use in pregnancy especially in the first trimester.
Use in Lactation: No information is available on excretion in breast milk, therefore it is advisable not to use during lactation.
Use in Lactation: No information is available on excretion in breast milk, therefore it is advisable not to use during lactation.
Adverse Reactions
dl-Alpha-Tocopheryl Acetate (Vitamin E) is usually well tolerated.
Large doses may cause diarrhoea, abdominal pain, and other gastrointestinal disturbances, blurred vision, dizziness, fatigue and weakness.
Large doses may cause diarrhoea, abdominal pain, and other gastrointestinal disturbances, blurred vision, dizziness, fatigue and weakness.
Drug Interactions
dl-Alpha-Tocopheryl Acetate (Vitamin E) may increase the risk of thrombosis in patients taking oestrogens.
Various drugs may interfere with the absorption of Vitamin E including colestyramine, colestipol and orlistat.
High doses of Vitamin E may increase the effects of oral anticoagulants.
Various drugs may interfere with the absorption of Vitamin E including colestyramine, colestipol and orlistat.
High doses of Vitamin E may increase the effects of oral anticoagulants.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: dl-Alpha-Tocopheryl Acetate (Vitamin E) is known to exert an important physiological function as an antioxidant for fats, with a sparing action on Vitamin A, carotenoids and on unsaturated fatty acids. Other work has demonstrated that Vitamin E is connected with the maintenance of certain factors essential for the normal metabolic cycle.
Pharmacokinetics: Absorption of dl-Alpha-Tocopheryl Acetate (Vitamin E) from the gastrointestinal tract is dependent on the presence of bile and on normal pancreatic function. The amount of Vitamin E absorbed varies widely between about 20% and 80% and appears to decrease as the dose is increased.
It enters the blood via the chylomicrons in the lymph and it is bound to beta lipoproteins. It is widely distributed to all tissues, and stored in adipose tissue.
Some Vitamin E is metabolised in the liver to glucuronides of tocopheronic acid and its γ-lactone. Some is excreted in the urine, but most of a dose is slowly excreted in the bile.
dl-Alpha-Tocopheryl Acetate (Vitamin E) appears in breast milk but it is poorly transferred across the placenta.
Pharmacokinetics: Absorption of dl-Alpha-Tocopheryl Acetate (Vitamin E) from the gastrointestinal tract is dependent on the presence of bile and on normal pancreatic function. The amount of Vitamin E absorbed varies widely between about 20% and 80% and appears to decrease as the dose is increased.
It enters the blood via the chylomicrons in the lymph and it is bound to beta lipoproteins. It is widely distributed to all tissues, and stored in adipose tissue.
Some Vitamin E is metabolised in the liver to glucuronides of tocopheronic acid and its γ-lactone. Some is excreted in the urine, but most of a dose is slowly excreted in the bile.
dl-Alpha-Tocopheryl Acetate (Vitamin E) appears in breast milk but it is poorly transferred across the placenta.
MedsGo Class
Vitamins A, D & E
Features
Dosage
400 I.U.
Ingredients
- Vit. E
Packaging
SoftGel Capsule 1's
Generic Name
Vit. E
Registration Number
DRP-1739
Classification
Over-The-Counter (OTC)
Product Questions
Questions
