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Indications/Uses
Sodium Ascorbate + Zinc (Dayzinc) is used for the treatment and prevention of Vitamin C and Zinc deficiency. It completely reverses symptoms of deficiency. Vitamin C deficiency leads to the development of a well-defined syndrome known as scurvy. This is characterized by capillary fragility, bleeding (especially from small blood vessels and the gums), anemias, cartilage and bone lesions, and slow healing of wounds. Features of Zinc deficiency include growth retardation and defects of rapidly-dividing tissues such as the skin, the immune system and the intestinal mucosa.
Dosage/Direction for Use
Cap: Adult: 1 capsule daily.
Chewable Tab: Adult: 2 tablet daily.
Children 4-15 years old: 1/2 - 1 tablet.
Children > 15 years old: 2 tablet daily.
Syrup: Under 2 years old: 2.5 mL (1/2 tsp).
2-6 years old: 2.5-5 mL (1/2-1 tsp).
7-12 years old: 5-10 mL (1-2 tsp).
Oral drops: Children < 3 months: 0.3 mL.
Children 3-12 months: 0.6 mL.
To be taken once daily or as prescribed by the physician.
Chewable Tab: Adult: 2 tablet daily.
Children 4-15 years old: 1/2 - 1 tablet.
Children > 15 years old: 2 tablet daily.
Syrup: Under 2 years old: 2.5 mL (1/2 tsp).
2-6 years old: 2.5-5 mL (1/2-1 tsp).
7-12 years old: 5-10 mL (1-2 tsp).
Oral drops: Children < 3 months: 0.3 mL.
Children 3-12 months: 0.6 mL.
To be taken once daily or as prescribed by the physician.
Overdosage
Vitamin C: Large doses may cause gastrointestinal disorders including diarrhoea. Large doses may also result in hyperoxaluria and renal oxalate calculi may form if urine is acidic. Doses of 600 mg or more daily have a diuretic action. Stop treatment and treat symptomatically.
Zinc Sulfate Monohydrate: Zinc sulfate is corrosive in overdosage. Symptoms are corrosion and inflammation of the mucous membrane of the mouth and stomach; ulceration of the stomach followed by perforation may occur. Gastric lavage and emesis should be avoided. Demulcents such as milk should be given. Chelating agents such as sodium calcium edetate may be useful.
Zinc Sulfate Monohydrate: Zinc sulfate is corrosive in overdosage. Symptoms are corrosion and inflammation of the mucous membrane of the mouth and stomach; ulceration of the stomach followed by perforation may occur. Gastric lavage and emesis should be avoided. Demulcents such as milk should be given. Chelating agents such as sodium calcium edetate may be useful.
Administration
Should be taken on an empty stomach: Best taken at least 1 hr before or 2 hr after meals. May be taken w/ meals to reduce GI discomfort.
Special Precautions
Ascorbic Acid should be given with care to patients with hyperoxaluria.
Adverse Reactions
Ascorbic Acid is usually well tolerated. Large doses are reported to cause diarrhea and other gastrointestinal disturbances. Oxalate calculi, renal failure, intravascular hemolysis, and tolerance may also result with prolonged use of large doses. Zinc sulfate which is the form of Zinc often used for oral administration may also cause gastrointestinal effects.
Drug Interactions
Vitamin C: Aspirin, Nicotine, Appetite Suppressant, Iron, Phenytoin, Anti-Convulsant Drugs, Estrogen containing oral contraceptive and tetracycline: Concomitant use with ascorbic acid may induce tissue desaturation of ascorbic acid.
Fluphenazine: Ascorbic acid decreased the plasma concentration of fluphenazine.
Aspirin: Reduce the absorption of ascorbic acid by approximately a third and decreases urinary excretion by about half.
Antacids/Aluminum Containing Antacids: Ascorbic Acid increase urinary aluminum elimination concurrent administration of antacids with ascorbic is not recommended especially with renal insufficient patient.
Oral Contraceptives: Lowers the serum levels of ascorbic acid.
Zinc Sulfate Monohydrate: Copper: Zinc may inhibit the absorption of copper.
Tetracycline Antibacterials: Zinc may reduce the absorption of concurrently administered tetracyclines, also the absorption of zinc may be reduced by tetracyclines; when both are being given an interval of at least three hours should be allowed.
Quinolone Antibacterials: Zinc may reduce the absorption of quinolones; ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin.
Calcium Salts: The absorption of zinc may be reduced by calcium salts.
Iron: The absorption of zinc may be reduced by oral iron, also the absorption of oral iron may be reduced by zinc.
Penicillamine: The absorption of zinc may be reduced by penicillamine, also the absorption of penicillamine may be reduced by zinc.
Trientine: The absorption of zinc may be reduced by trientine, also the absorption of trientine maybe reduced by zinc.
Fluphenazine: Ascorbic acid decreased the plasma concentration of fluphenazine.
Aspirin: Reduce the absorption of ascorbic acid by approximately a third and decreases urinary excretion by about half.
Antacids/Aluminum Containing Antacids: Ascorbic Acid increase urinary aluminum elimination concurrent administration of antacids with ascorbic is not recommended especially with renal insufficient patient.
Oral Contraceptives: Lowers the serum levels of ascorbic acid.
Zinc Sulfate Monohydrate: Copper: Zinc may inhibit the absorption of copper.
Tetracycline Antibacterials: Zinc may reduce the absorption of concurrently administered tetracyclines, also the absorption of zinc may be reduced by tetracyclines; when both are being given an interval of at least three hours should be allowed.
Quinolone Antibacterials: Zinc may reduce the absorption of quinolones; ciprofloxacin, levofloxacin, moxifloxacin, norfloxacin and ofloxacin.
Calcium Salts: The absorption of zinc may be reduced by calcium salts.
Iron: The absorption of zinc may be reduced by oral iron, also the absorption of oral iron may be reduced by zinc.
Penicillamine: The absorption of zinc may be reduced by penicillamine, also the absorption of penicillamine may be reduced by zinc.
Trientine: The absorption of zinc may be reduced by trientine, also the absorption of trientine maybe reduced by zinc.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Vitamin C: Ascorbic acid, a water-soluble vitamin, is essential for formation of collagen and intercellular material, and therefore necessary for the development of cartilage, bone, teeth and for the healing of wounds. It is also essential for the conversation from folic acid to folinic acid, facilitates iron absorption from the gastro-intestinal tract and influences haemoglobin formation and erythrocyte maturation.
Zinc Sulfate (as Monohydrate): Zinc is an essential trace element involved in many enzyme systems. Severe deficiency causes skin lesion, alopecia, diarrhoea, increased susceptibility to infections and failure to thrive in children. Symptoms of less severe deficiency include distorted or absent perceptions of taste and smell and poor wound healing.
Pharmacokinetics: Vitamin C: Distribution: widely distributed in body tissues with about 25% bound to plasma proteins. Large amounts are present in leucocytes and platelets. Ascorbic acid crosses the placenta.
Metabolism: readily oxidised to dehydroascorbic acid where some is metabolised to oxalic acid and the inactive ascorbate-2-sulphate. Metabolic turnover appears to be greater in females than males.
Excretion: large doses are rapidly excreted in the urine when in excess of the requirements of the body and after an intravenous dose, about 40% is excreted in 8 hours, which is increased to about 70% after tissue saturation. The amount of unchanged drug is dose dependent; in women the excretion of ascorbic acid appears to vary with the stage of the menstrual cycle and it is decreased when taking oral contraceptives. Ascorbic acid is excreted in breast milk.
Oxalic acid and ascorbate-2-sulphate are excreted in the urine.
Zinc Sulfate (as Monohydrate): Zinc is absorbed from the gastrointestinal tract and distributed throughout the body. The highest concentrations occur in hair, eyes, male reproductive organs and bone. Lower levels are present in liver, kidney and muscle. In blood 80% is found in erythrocytes. Plasma zinc levels range from 70 to 110 μg/dL and about 50% of this is loosely bound to albumin. About 7% is amino-acid bound and the rest is tightly bound to alpha 2-macroglobulins and other proteins.
Zinc Sulfate (as Monohydrate): Zinc is an essential trace element involved in many enzyme systems. Severe deficiency causes skin lesion, alopecia, diarrhoea, increased susceptibility to infections and failure to thrive in children. Symptoms of less severe deficiency include distorted or absent perceptions of taste and smell and poor wound healing.
Pharmacokinetics: Vitamin C: Distribution: widely distributed in body tissues with about 25% bound to plasma proteins. Large amounts are present in leucocytes and platelets. Ascorbic acid crosses the placenta.
Metabolism: readily oxidised to dehydroascorbic acid where some is metabolised to oxalic acid and the inactive ascorbate-2-sulphate. Metabolic turnover appears to be greater in females than males.
Excretion: large doses are rapidly excreted in the urine when in excess of the requirements of the body and after an intravenous dose, about 40% is excreted in 8 hours, which is increased to about 70% after tissue saturation. The amount of unchanged drug is dose dependent; in women the excretion of ascorbic acid appears to vary with the stage of the menstrual cycle and it is decreased when taking oral contraceptives. Ascorbic acid is excreted in breast milk.
Oxalic acid and ascorbate-2-sulphate are excreted in the urine.
Zinc Sulfate (as Monohydrate): Zinc is absorbed from the gastrointestinal tract and distributed throughout the body. The highest concentrations occur in hair, eyes, male reproductive organs and bone. Lower levels are present in liver, kidney and muscle. In blood 80% is found in erythrocytes. Plasma zinc levels range from 70 to 110 μg/dL and about 50% of this is loosely bound to albumin. About 7% is amino-acid bound and the rest is tightly bound to alpha 2-macroglobulins and other proteins.
MedsGo Class
Vitamins &/or Minerals
Features
Brand
Dayzinc
Full Details
Dosage Strength
225mg / 50mg / 5mg
Drug Ingredients
- Ascorbic Acid
- Sodium Ascorbate
- Zinc
Drug Packaging
Chewable Tablet 1's
Generic Name
Ascorbic Acid / Sodium Ascorbate / Zinc
Dosage Form
Chewable Tablet
Registration Number
DR-XY42647
Drug Classification
Over-The-Counter (OTC)