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Indications/Uses
For the treatment of neuritis, neuralgias, shoulder-arm syndrome, facial paresis, pregnancy neuritis, drug-induced and alcoholic neuropathy, diabetic neuropathy, sciatica, lumbago-lumbalgia, intercostal neuralgia, dry and wet beriberi, trigeminal neuralgia, optic neuritis, numbness of extremities, hyperemesis gravidarum and Vitamin B1, B6, B12 deficiencies.
Dosage/Direction for Use
Therapeutic Dose: 2-4 tablets daily until acute symptoms subside. Chronic cases may require longer therapy.
Prophylactic Dose: 1 to 2 tablets daily when disease or drugs are likely to lead to neurological complications or as prescribed by the physician.
Prophylactic Dose: 1 to 2 tablets daily when disease or drugs are likely to lead to neurological complications or as prescribed by the physician.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Not given to patients with history of hypersensitivity to the components of Cyanocobalamin and should not be given to patients with suspected Vitamin B12 deficiency without confirmation of the diagnosis.
Special Precautions
Use of Cyanocobalamin is not recommended to lactating mothers; benefit to mother should outweigh risk to the infant. Vitamin B12 is excreted into human breast milk. Women taking oral contraceptives may need increased pyridoxine requirements.
Adverse Reactions
Hypersensitivity reactions range from very mild to very rarely anaphylactic shock. Adverse effects include nausea, mild rash and stomach upset which seldom occurs after oral administration of Thiamine and Cyanocobalamin. Long-term administration (more than two months) of Pyridoxine (more than 2 g daily) is associated with the development of severe peripheral neuropathy.
Drug Interactions
The effect of thiamine is neutralized by antagonists (thiosemicarbazone) and 5-fluorouracil. Patients using any of these treatments may need their thiamine dose adjusted. Pyridoxine increases metabolism of barbiturates and phenytoin. Chloramphenicol and colchicine decreases serum concentration of Cyanocobalamin. Avoid intake of drugs with same content to prevent overdose. Heavy alcohol intake for more than two weeks causes malabsorption of Vitamin B12. Levodopa action is antagonized by Vitamin B6.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Thiamine is important for aerobic metabolism, cell growth, transmission of nerve impulses and acetylcholine synthesis. It is needed to maintain the health of the nerves and the heart. It combines with adenosine triphosphate (ATP) to form a coenzyme, thiamine pyrophosphate or cocarboxylase which is necessary for carbohydrate metabolism.
Pyridoxine is converted into its active form, pyridoxal 5'-phosphate (PLP), an essential cofactor in many enzymatic activities including synthesis of amino acids, neurotransmitters (serotonin, dopamine, norepinephrine and GABA), and sphingolipids.
Cyanocobalamin combines with an intrinsic factor for absorption in the intestine. It is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. It is vital for myelin sheath formation which protects the nerve fiber and influences the speed of signal transmission.
Pharmacokinetics: Thiamine is absorbed from the GI tract and is widely distributed to most body tissues. It is not stored to any appreciable extent in the body and amounts in excess of requirements are excreted in the urine as unchanged thiamine or metabolites.
Pyridoxine is absorbed from the GI tract and is converted to the active form pyridoxal phosphate. It is stored mainly in liver with lesser amounts in muscle and brain. It also crosses the placenta and is distributed into milk. It is excreted in the urine as 4-pyridoxic acid.
Cyanocobalamin is irregularly absorbed from the distal small intestine following oral administration. It requires gastric intrinsic factor for active absorption from the GI tract. It is distributed into liver, bone marrow, and other tissues. It also crosses the placenta and is distributed into milk. More than 50-98% may be excreted in urine.
Pyridoxine is converted into its active form, pyridoxal 5'-phosphate (PLP), an essential cofactor in many enzymatic activities including synthesis of amino acids, neurotransmitters (serotonin, dopamine, norepinephrine and GABA), and sphingolipids.
Cyanocobalamin combines with an intrinsic factor for absorption in the intestine. It is necessary for hematopoiesis, neural metabolism, DNA and RNA production, and carbohydrate, fat, and protein metabolism. It is vital for myelin sheath formation which protects the nerve fiber and influences the speed of signal transmission.
Pharmacokinetics: Thiamine is absorbed from the GI tract and is widely distributed to most body tissues. It is not stored to any appreciable extent in the body and amounts in excess of requirements are excreted in the urine as unchanged thiamine or metabolites.
Pyridoxine is absorbed from the GI tract and is converted to the active form pyridoxal phosphate. It is stored mainly in liver with lesser amounts in muscle and brain. It also crosses the placenta and is distributed into milk. It is excreted in the urine as 4-pyridoxic acid.
Cyanocobalamin is irregularly absorbed from the distal small intestine following oral administration. It requires gastric intrinsic factor for active absorption from the GI tract. It is distributed into liver, bone marrow, and other tissues. It also crosses the placenta and is distributed into milk. More than 50-98% may be excreted in urine.
MedsGo Class
Vitamin B-Complex / with C
Features
Brand
Triobees
Full Details
Dosage Strength
Hcl 500 mg / 250 mg / 1 mg
Drug Ingredients
- Vit. B1
- Vit. B12
- Vit. B6
Drug Packaging
Film-Coated Tablet 20's
Generic Name
Vit. B1 / Vit. B12 / Vit. B6
Dosage Form
Film-Coated Tablet
Registration Number
DR-XY42924
Drug Classification
Prescription Drug (RX)