POLYNERV 1000 Vitamin B Complex 250mg / 250mg / 1mg Film-Coated Tablet 1's
NONRXDRUG-DR-XY36320-1pc
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Features
Brand
Polynerv 1000
Full Details
Dosage Strength
250 mg / 250 mg / 1 mg
Drug Ingredients
- Vit. B1
- Vit. B12
- Vit. B6
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Thiamine Mononitrate (Vit. B1) / Pyridoxine Hydrochloride (Vit. B6) / Cyanocobalamin (Vit. B12)
Dosage Form
Film-Coated Tablet
Registration Number
DR-XY36320
Drug Classification
Over-The-Counter (OTC)
Description
Indications/Uses
For the prophylaxis and treatment of vitamin B1, B6 and B12 deficiencies associated with restricted diet, illnesses, impaired absorption and utilization of B vitamins resulting from prolonged antibiotic therapy and intake of certain drugs. As adjuvant or support in the comprehensive management of neuritis, polyneuritis, neuralgia, diabetes, alcoholism and drug induced neuropathies, hyperemesis gravidarum, optic neuritis, facial paresis, trigeminal neuralgia, shoulder-arm syndrome, herpes zoster, lumbago, numbness of the extremities, sciatica.
Dosage/Direction for Use
Prophylactic: 1-2 tablets daily.
Therapeutic: 2-4 tablets daily.
Or as prescribed by the physician.
Therapeutic: 2-4 tablets daily.
Or as prescribed by the physician.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort.
Use In Pregnancy & Lactation
Use in Pregnancy: Cyanocobalamin (Vitamin B12) should not be used to treat megaloblastic anemia of pregnancy.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Vitamin B1 + B6 + B12 as coenzymes, activate the metabolic processes by which the breakdown products of carbohydrates, fats and proteins are further transformed and utilized by the different body cells.
Vitamin B1 + B6 + B12 therefore stimulate the various metabolic processes of the body which produce the energy needed to fuel the cellular activities of the body, specially the physiologic activities of the nervous system.
Thiamine Mononitrate (B1) as a coenzyme of glucose metabolism ensures the efficient production of energy from glucose and the conversion of glucose into other metabolites such as ribose, a major component of DNA and RNA. The cells of the nervous system depend entirely on glucose as its energy source. Independent of its coenzyme function, thiamine acts as a modulator in neuromuscular transmission.
Vitamin B1 + B6 + B12 (POLYNERV 1000) with its high concentration of pyridoxine hydrochloride is involved in various metabolic transformations of amino acids needed for tissue building and repair and in the biosynthesis of neurotransmitters and blood elements.
Vitamin B1 + B6 + B12 (POLYNERV 1000) gives high amount of cyanocobalamin, a coenzyme which promotes metabolism of nucleic acids and some fatty acids necessary for formation of new cells.
The substantial concentration of B1 + B6 + B12 in POLYNERV 1000 will ensure optimum nutrition of neuronal cells essential for a more efficient functioning of the neuromuscular system.
Pharmacokinetics: Following oral administration, thiamine is absorbed from the gastrointestinal tract and is widely distributed to most body tissues. Thiamine is mostly present within the cells as diphosphate. Thiamine is not stored in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites.
Pyridoxine is readily absorbed from the gastrointestinal tract. It is converted to the active form pyridoxal phosphate and is stored mainly in the liver. Amounts in excess of the body's requirements are excreted unchanged in the urine. Pyridoxal diffuses across the placenta and appears in breast milk.
Vitamin B12 compounds which bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa are then actively absorbed from the gastrointestinal tract. Little amount is absorbed by passive diffusion but the process becomes increasingly important with larger or therapeutic amounts.
Vitamin B12 is extensively bound to transcobalamin, a plasma protein. Vitamin B12 is stored in the liver and excreted in the bile. Part of a dose is excreted in the urine. Vitamin B12 diffuses across the placenta and is also distributed into breast milk.
Vitamin B1 + B6 + B12 therefore stimulate the various metabolic processes of the body which produce the energy needed to fuel the cellular activities of the body, specially the physiologic activities of the nervous system.
Thiamine Mononitrate (B1) as a coenzyme of glucose metabolism ensures the efficient production of energy from glucose and the conversion of glucose into other metabolites such as ribose, a major component of DNA and RNA. The cells of the nervous system depend entirely on glucose as its energy source. Independent of its coenzyme function, thiamine acts as a modulator in neuromuscular transmission.
Vitamin B1 + B6 + B12 (POLYNERV 1000) with its high concentration of pyridoxine hydrochloride is involved in various metabolic transformations of amino acids needed for tissue building and repair and in the biosynthesis of neurotransmitters and blood elements.
Vitamin B1 + B6 + B12 (POLYNERV 1000) gives high amount of cyanocobalamin, a coenzyme which promotes metabolism of nucleic acids and some fatty acids necessary for formation of new cells.
The substantial concentration of B1 + B6 + B12 in POLYNERV 1000 will ensure optimum nutrition of neuronal cells essential for a more efficient functioning of the neuromuscular system.
Pharmacokinetics: Following oral administration, thiamine is absorbed from the gastrointestinal tract and is widely distributed to most body tissues. Thiamine is mostly present within the cells as diphosphate. Thiamine is not stored in the body and amounts in excess of the body's requirements are excreted in the urine as unchanged thiamine or as metabolites.
Pyridoxine is readily absorbed from the gastrointestinal tract. It is converted to the active form pyridoxal phosphate and is stored mainly in the liver. Amounts in excess of the body's requirements are excreted unchanged in the urine. Pyridoxal diffuses across the placenta and appears in breast milk.
Vitamin B12 compounds which bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa are then actively absorbed from the gastrointestinal tract. Little amount is absorbed by passive diffusion but the process becomes increasingly important with larger or therapeutic amounts.
Vitamin B12 is extensively bound to transcobalamin, a plasma protein. Vitamin B12 is stored in the liver and excreted in the bile. Part of a dose is excreted in the urine. Vitamin B12 diffuses across the placenta and is also distributed into breast milk.
MedsGo Class
Vitamin B-Complex / with C
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