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Indications/Uses
Premature babies, low birth weight, retarded growth, poor appetite in infants, children and adults, adjuvant to treatment of TB and other chronic ailment, convalescence from acute infection or surgery, faulty nutrition in older people.
Dosage/Direction for Use
DIBENCOZIDE 1 mg Capsule: See Table 1.
Or as prescribed by the physician.
DIBENCOZIDE 3 mg Capsule: See Table 2.
DIBENCOZIDE 3 mg Capsule: See Table 2.
Or as prescribed by the physician.
Overdosage
It is unlikely that an overdose will occur if the prescribe dose are followed correctly. However stop this medication and ask the doctor if patient is feeling unwell or any or if overdose is suspected.
Special Precautions
Use in Pregnancy and Lactation: Not enough is known about the use of Dibencozide during pregnancy and breastfeeding. Stay on the safe side and avoid use, GI conditions such as ileal disease or surgical removal part of the intestine can reduce the amount of Vitamin B12 including dibencozide that is absorbed from the intestine.
Adverse Reactions
All drugs are subject to side effects and it may vary from individual to individual. Use the drug exactly as prescribed by the doctor and in case of any symptoms of adverse reactions, stop using the drug immediately and consult a doctor. No major adverse reactions have been associated to the use of dibencozide Capsules.
Minor side effects include nausea, vomiting, diarrhea, acidity, headache, stomach upset and other GI disorders. Inform the doctor in case any such symptoms become chronic and troublesome.
Stop using the drug immediately and seek for immediate medical help in case of any symptoms of allergic reactions such as rashes, hives and inflammation.
Minor side effects include nausea, vomiting, diarrhea, acidity, headache, stomach upset and other GI disorders. Inform the doctor in case any such symptoms become chronic and troublesome.
Stop using the drug immediately and seek for immediate medical help in case of any symptoms of allergic reactions such as rashes, hives and inflammation.
Drug Interactions
Absorption of Vitamin B12 from the GIT may be reduced by Neomycin, Amino salicylic acid, Histamine H2 antagonist, Omeprazole and Colchicines. Serum concentration may be decreased by use of oral contraceptives. Many of this interaction are unlikely to be of clinical significance but should be taken into account when performing assays for blood concentration. Parenteral chloramphenicol may attenuate the effect of Vitamin B12 in anemia.
Caution For Usage
Instruction and Special Precaution for Handling and Disposal: No special handling and disposal required.
Storage
Store at temperature not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Mechanism of Action: Dibencozide is one of the active forms of Vitamin B12. Dibencozide increases the protein "efficiency coefficient" for example, the proportion of "bound nitrogen" for protein fabrication in the system evaluated to "consumed nitrogen" with food ingestion. The initial sign of effectiveness is manifested by a marked increase in appetite.
Thus, dibencozide facilitates optimum utilization of dietary protein intake, contributes to the formation and repair of body tissues and stimulates appetite.
Pharmacokinetics: Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract. Absorption is impaired in patients with an absence of intrinsic factor, with a malabsorption syndrome or with disease or abnormality of the gut, or after gastrectomy. Absorption from the gastrointestinal tract can also occur by passive diffusion; little of the vitamin present in food is absorbed in this manner although the process becomes increasingly important with larger amounts such as those used therapeutically. After intranasal dosage, peak plasma concentrations of cyanocobalamin have been reached in 1 to 2 hours. The bioavailability of the intranasal preparation is about 7 to 11% of that by intramuscular injection.
Thus, dibencozide facilitates optimum utilization of dietary protein intake, contributes to the formation and repair of body tissues and stimulates appetite.
Pharmacokinetics: Vitamin B12 substances bind to intrinsic factor, a glycoprotein secreted by the gastric mucosa, and are then actively absorbed from the gastrointestinal tract. Absorption is impaired in patients with an absence of intrinsic factor, with a malabsorption syndrome or with disease or abnormality of the gut, or after gastrectomy. Absorption from the gastrointestinal tract can also occur by passive diffusion; little of the vitamin present in food is absorbed in this manner although the process becomes increasingly important with larger amounts such as those used therapeutically. After intranasal dosage, peak plasma concentrations of cyanocobalamin have been reached in 1 to 2 hours. The bioavailability of the intranasal preparation is about 7 to 11% of that by intramuscular injection.
MedsGo Class
Vitamin B-Complex / with C
Features
Brand
Cozin
Full Details
Dosage Strength
3 mg
Drug Ingredients
- Dibencozide
Drug Packaging
Capsule 1's
Generic Name
Dibencozide
Dosage Form
Capsule
Registration Number
DRP-6558
Drug Classification
Prescription Drug (RX)