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Indications/Uses
Respiratory disorders complicated by bronchospasm and excessive secretion of tenacious mucus, bronchial asthma, chronic bronchitis and emphysema.
Dosage/Direction for Use
Adults: 2-4 tsp (10-20 mL) 2 or 3 times daily.
Children 6-12 years: 2 tsp (10 mL) 3 or 4 times daily, 2-6 years: 1 tsp (5 mL) 3 or 4 times daily.
Or as prescribed by the physician.
Children 6-12 years: 2 tsp (10 mL) 3 or 4 times daily, 2-6 years: 1 tsp (5 mL) 3 or 4 times daily.
Or as prescribed by the physician.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.
Special Precautions
The management of asthma involves prophylactic measures to reduce inflammation and airway resistance and to maintain airflow and specific regimens for the treatment of acute attacks. Lung function measurement is important in determining treatment thus, peak flow monitoring is encouraged. If usual relief is diminished or the duration of action is reduced, patients are warned not to increase the dose or frequency of administration but seek medical advice.
Salbutamol should be given with caution in hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, hypertension and diabetes mellitus.
In severe asthma, particular precaution is required to avoid inducing hypokalemia as this effect may be potentiated by hypoxia or by concomitant administration of other antiasthma drugs. Plasma potassium concentrations should be monitored.
Salbutamol should be given with caution in hyperthyroidism, myocardial insufficiency, arrhythmias, susceptibility to QT-interval prolongation, hypertension and diabetes mellitus.
In severe asthma, particular precaution is required to avoid inducing hypokalemia as this effect may be potentiated by hypoxia or by concomitant administration of other antiasthma drugs. Plasma potassium concentrations should be monitored.
Use In Pregnancy & Lactation
Drug administration during pregnancy should only be considered if the expected benefit to the mother outweighs any possible risk to the fetus.
The use of salbutamol is not recommended in nursing mothers unless the expected benefit is greater than any possible risks.
The use of salbutamol is not recommended in nursing mothers unless the expected benefit is greater than any possible risks.
Adverse Reactions
Salbutamol may cause fine tremor of skeletal muscles (particularly the hands), palpitations, tachycardia, nervous tension, headaches, peripheral vasodilation and rarely, muscle cramps to some patients.
Very rarely, hypersensitivity reactions eg, bronchospasm, urticaria, angioedema, hypotension and collapse have been reported with salbutamol.
Side effects eg, GI discomfort, nausea and vomiting have occasionally been reported with guaifenesin, particularly in very large doses.
Very rarely, hypersensitivity reactions eg, bronchospasm, urticaria, angioedema, hypotension and collapse have been reported with salbutamol.
Side effects eg, GI discomfort, nausea and vomiting have occasionally been reported with guaifenesin, particularly in very large doses.
Storage
Store at temperatures not exceeding 30°C.
Shelf-Life: 36 months.
Shelf-Life: 36 months.
Action
Pharmacology: Guaifenesin possesses mucolytic properties. Mucolytics are agents that alter the structure of mucus to decrease its viscosity thereby facilitating its removal by ciliary action or expectoration. Although mucolytics have been shown to affect sputum viscosity and structure and patients have reported alleviation of their symptoms, no consistent improvement has been demonstrated in lung function. Guaifenesin is reported to reduce the viscosity of tenacious sputum and is used as an expectorant for productive cough.
On the other hand, salbutamol is a direct-acting sympathomimetic agent with predominantly β-adrenergic activity and selective action on β2-receptors. It is used as a bronchodilator. It has more prolonged actions than isoprenaline and as a predominantly β2-stimulant, has a bronchodilating action relatively more prominent than its effect on the heart. An additional beneficial effect of salbutamol is its action on the uterus as a relaxant. The uterine muscles contract under β-adrenergic stimulation. Thus, it has gained popularity among obstetricians for controlling premature labor. However, a relative contraindication to its use is among pregnant patients with vaginal bleeding because it may cause pulmonary edema.
On the other hand, salbutamol is a direct-acting sympathomimetic agent with predominantly β-adrenergic activity and selective action on β2-receptors. It is used as a bronchodilator. It has more prolonged actions than isoprenaline and as a predominantly β2-stimulant, has a bronchodilating action relatively more prominent than its effect on the heart. An additional beneficial effect of salbutamol is its action on the uterus as a relaxant. The uterine muscles contract under β-adrenergic stimulation. Thus, it has gained popularity among obstetricians for controlling premature labor. However, a relative contraindication to its use is among pregnant patients with vaginal bleeding because it may cause pulmonary edema.
MedsGo Class
Cough & Cold Preparations
Features
Brand
Ventar EXP
Full Details
Dosage Strength
50mg / 1mg per 5ml
Drug Ingredients
- Guaifenesin
- Salbutamol
Drug Packaging
Syrup 60ml
Generic Name
Guaifenesin / Salbutamol
Dosage Form
Syrup
Registration Number
DR-XY27287
Drug Classification
Prescription Drug (RX)