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Basahin sa Tagalog | Want to buy in person? Find a MedsGo Pharmacy near you
Pyrazinamide is a powerful TB fighter—an essential antibiotic that works with other medicines to eliminate tuberculosis bacteria from your body. Think of it as part of your "TB elimination team," specifically targeting stubborn bacteria hiding in your lungs during the critical first 2 months of treatment.
- ✅ 500mg tablets available (PNF standard)
- ✅ PNF Listed - Philippine National Formulary essential anti-TB medicine
- ✅ VAT-Exempt when combined with Rifampicin + Isoniazid (Save 12% on FDC combos!)
- ✅ No Prescription? Get a FREE teleconsultation with our licensed doctor during checkout
Understanding Pyrazinamide: Your TB Elimination Specialist
Pyrazinamide is a critical antimycobacterial antibiotic and essential component of tuberculosis (TB) treatment. As an essential medicine listed in the Philippine National Formulary 8th Edition under Anti-Tuberculosis Medicines, it is recognized by the Department of Health as a first-line treatment for active TB infection. Pyrazinamide is NEVER used alone—it always works as part of a combination therapy to ensure complete eradication of TB bacteria and prevent drug resistance.
How Pyrazinamide Works (Simple Explanation)
Imagine TB bacteria are like stubborn criminals hiding in different corners of your lungs. Pyrazinamide acts like a "special forces agent" with unique abilities:
- Targets semi-dormant TB bacteria that other drugs can't reach
- Works inside macrophages (your immune cells) where bacteria hide
- Reduces treatment duration from 9-12 months to just 6 months when combined with other drugs
- Prevents TB bacteria from developing resistance to treatment
Pyrazinamide Quick Guide: What You Need to Know
| Available Strengths | 500mg tablets; 250mg/5mL and 500mg/5mL suspension (PNF standard) |
| Standard Dosage | 15-30 mg per kg body weight once daily (typically 1-2 tablets daily for adults); or 50-70 mg/kg 2-3 times weekly under Directly Observed Therapy (DOTS) program |
| Duration of Use | First 2 months of TB treatment only (intensive phase), combined with Isoniazid, Rifampicin, and Ethambutol |
| Best Time to Take | Once daily, preferably at the same time. Can take with food to reduce stomach upset⏰ |
| Key Benefits | Shortens TB treatment duration, kills dormant bacteria, prevents relapse, reduces transmission |
Why Choose Pyrazinamide from MedsGo?
- ✅ PNF Quality Assurance: Our Pyrazinamide complies with Philippine National Formulary standards (500mg tablets), ensuring you receive essential anti-TB medicine that meets DOH requirements for the National Tuberculosis Control Program.
- ✅ VAT Savings on Combinations: Pyrazinamide + Rifampicin + Isoniazid fixed-dose combinations (75mg/50mg/150mg dispersible tablets) are VAT-exempt under FDA Advisory No. 2025-0498 (April 2025). This FDC saves you 12% automatically!
- ✅ Temperature-Controlled Storage: Unlike generic warehouses, our FDA-registered pharmacies store anti-TB medicines properly to maintain potency and prevent degradation.
- ✅ Doctor Care Included: No prescription? No problem. Add to cart and get a FREE teleconsultation with our licensed physician—no hidden fees.
- ✅ Fast & Safe Delivery: Or pick up at any MedsGo pharmacy nationwide for same-day availability.
- ✅ DOTS Program Support: We support the Philippine National Tuberculosis Control Program's Directly Observed Therapy Short-course (DOTS) strategy.
Conditions Pyrazinamide Treats
- Active Pulmonary Tuberculosis: TB infection in the lungs (most common form)
- Extra-pulmonary Tuberculosis: TB affecting lymph nodes, bones, joints, or other organs
- TB Meningitis: Pyrazinamide crosses the blood-brain barrier to treat TB in the brain
- Multi-drug Resistant TB (MDR-TB): Used in combination with second-line drugs for resistant strains
Critical Safety Information: What to Watch For ⚠︎
Pyrazinamide is generally safe but requires careful monitoring. Be a smart medicine user:
- Common: Nausea, vomiting, loss of appetite, joint pain (arthralgia), flushing—usually manageable with food or pain relievers
- Watch For (Uric Acid/Gout): Sudden joint pain, redness, swelling (especially big toe), stiffness—Pyrazinamide raises uric acid levels. Contact our doctor if you have gout symptoms
- Watch For (Liver): Yellowing skin/eyes, dark urine, severe stomach pain, persistent nausea/vomiting, unusual tiredness—these may signal liver problems. Seek immediate medical attention
- Important: NEVER stop taking Pyrazinamide without consulting your doctor, even if you feel better. Stopping early can cause TB to return and become drug-resistant
- Diabetes Note: May cause false urine ketone test results. Inform our doctor if you have diabetes during teleconsultation
- Contraindications: Not for patients with severe liver disease or active gout. Your doctor will check liver enzymes and uric acid before starting treatment
Mahalagang Impormasyon sa Tagalog
Pyrazinamide: Ang Espesyalista sa Pagpuksa ng TB
Ang Pyrazinamide ay isang mahalagang antimycobacterial antibiotic at kailangang bahagi ng panggagamot sa tuberculosis (TB). Ayon sa Philippine National Formulary 8th Edition, ito ay kinikilalang essential medicine ng Department of Health para sa first-line treatment ng active TB infection. Ang Pyrazinamide ay HINDI KAILANMAN ginagamit mag-isa—laging kasama ito sa combination therapy para matiyak ang pagpuksa ng TB bacteria at maiwasan ang drug resistance.
Paano Gumagana ang Pyrazinamide?
Isipin na ang TB bacteria ay parang mga pasaway na kriminal na nagtatago sa iba't ibang sulok ng iyong baga. Ang Pyrazinamide ay parang "special forces agent" na may natatanging kakayahan: tinatarget nito ang semi-dormant TB bacteria na hindi maabot ng ibang gamot, gumagana sa loob ng macrophages (immune cells) kung saan nagtatago ang bacteria, at pinapapaikli ang treatment duration mula 9-12 buwan hanggang 6 na buwan lamang.
Ang Mahusay na Benepisyo ng Pagbili sa MedsGo
- ✅ PNF Quality: Sumusunod sa pamantayan ng Philippine National Formulary para sa anti-TB medicines
- ✅ VAT Discount sa Combos: Libre sa 12% VAT ang Pyrazinamide + Rifampicin + Isoniazid fixed-dose combinations (FDA Advisory No. 2025-0498)
- ✅ Libre Konsulta: Walang reseta? Libre ang teleconsultation sa aming doktor
- ✅ Pambansang Botika: Maaari ring bumili sa kahit anong MedsGo pharmacy sa buong bansa
- ✅ Suporta sa DOTS Program: Sumusuporta kami sa Philippine National Tuberculosis Control Program
Mga Kondisyon na Ginagamot ng Pyrazinamide
- Active Pulmonary Tuberculosis: TB infection sa baga (pinakakaraniwang form)
- Extra-pulmonary Tuberculosis: TB na nakakaapekto sa lymph nodes, buto, joints, o iba pang organs
- TB Meningitis: Ang Pyrazinamide ay tumatawid sa blood-brain barrier para gamutin ang TB sa utak
- Multi-drug Resistant TB (MDR-TB): Ginagamit kasama ang second-line drugs para sa resistant strains
Kritikal na Impormasyon sa Kaligtasan ⚠︎
- Karaniwan: Nausea, vomiting, loss of appetite, joint pain, flushing—kadalasang naiibsan sa pagkain o pain relievers
- Bantayan (Uric Acid/Gout): Biglaang pananakit ng joints, pamumula, pamamaga (lalo na sa big toe)—ang Pyrazinamide ay nagpataas ng uric acid. Tawagin ang doktor kung may gout symptoms
- Bantayan (Liver): Paninilaw ng balat/mata, madilim na ihi, severe stomach pain, persistent na nausea/vomiting—mga senyales ng liver problems. Maghanap agad ng medical attention
- IMPORTANTE: HUWAG TUMIGIL sa pag-inom ng Pyrazinamide nang hindi kinokonsulta ang doktor, kahit na magaling na ang pakiramdam. Ang pagtigil nang maaga ay maaaring magdulot ng pagbabalik ng TB at maging drug-resistant
- Paalala sa Diabetes: Maaaring magdulot ng false urine ketone test results. Sabihin sa doktor kung may diabete
