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Indications/Uses
Treatment of gout either primary or secondary to the hyperuricemia associated with blood dyscrasias and their therapy, primary or secondary uric acid nephropathy, with or without accompanying symptoms of gout; recurrent uric acid formation. Allurase is also used in prophylactic treatment to prevent tissue deposition, renal calculi, or uric acid nephropathy in patients with leukemias, lymphomas and malignancies who are receiving cancer chemotherapy with its resultant elevating effect on serum uric acid levels.
Dosage/Direction for Use
Adult Mild gout 100-200 mg/day. Moderately severe gout 300-600 mg/day. Severe hyperuricemia Up to 900 mg/day. Maintenance dose: 200-600 mg/day, up to 300 mg as single daily dose. Hyperuricemia & prevention of uric acid nephropathy associated w/ cancer therapy 600-800 mg/day in divided doses for 2-3 days. Childn 10-20 mg/kg body wt/day.
Administration
Should be taken with food.
Contraindications
Generally contraindicated in children except for those with hyperuricemia secondary to malignancy; in pregnant and lactating mothers and in patients with idiopathic hemochromatosis.
Special Precautions
Patients who have developed a severe reaction should not be restarted with the drug. Periodic liver function tests should be performed particularly in patients with pre-existing hepatic and renal diseases.
Adverse Reactions
Skin rash; exfoliative rashes, Stevens-Johnson syndrome, toxic epidermal necrolysis may occur. Fever, chills, leukopenia or leukocytosis, eosinophilia, arthralgia & vasculitis. GI disturbances, peripheral neuritis, alopecia, headache, drowsiness & vertigo.
Drug Interactions
Azathioprine & mercaptopurine. Thiazide diuretics. Captopril, theophylline & vidarabine.
Action
Allurase selectively inhibits action of xanthine oxidase, an essential enzyme responsible for synthesis of uric acid thus decreasing urate pool, resorbing tophaceous deposits and ultimately preventing hyperuricosuria.
MedsGo Class
Hyperuricemia & Gout Preparations
Features
Brand
Allurase
Full Details
Dosage Strength
100 mg
Drug Ingredients
- Allopurinol
Drug Packaging
Tablet 1's
Generic Name
Allopurinol
Dosage Form
Tablet
Registration Number
DR-XY700
Drug Classification
Prescription Drug (RX)