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Indications/Uses
Prevention and therapy of damages due to faulty or deficient protein metabolism in chronic renal insufficiency in connection with limited protein in food of ≤40 g/day (for adults) ie, generally in patients with a glomerular filtration rate (GFR) <25 mL/min.
Dosage/Direction for Use
4-8 tablets 3 times a day; 1 tablet/5 kg body wt/day.
Administration: Tablets should be taken with food. Swallow whole, do not chew/crush.
Administration: Tablets should be taken with food. Swallow whole, do not chew/crush.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Hypersensitivity to any of the contents of Renoket.
Hypercalcemia; disturbed amino acid metabolism; phenylketonuria.
Hypercalcemia; disturbed amino acid metabolism; phenylketonuria.
Special Precautions
Renoket should be taken during meals to allow proper absorption and metabolism into the corresponding amino acids. The serum calcium level should be monitored regularly. Ensure sufficient supply with calories.
Use in pregnancy and lactation: No experience has been made so far with the administration of Renoket during pregnancy and lactation.
Use in pregnancy and lactation: No experience has been made so far with the administration of Renoket during pregnancy and lactation.
Use In Pregnancy & Lactation
No experience has been made so far with the administration of Renoket during pregnancy and lactation.
Adverse Reactions
Hypercalcemia may develop in this case, it is recommended to decrease vitamin D intake.
If the hypercalcemia persists, reduce the dosage of Renoket as well as any source of calcium.
If the hypercalcemia persists, reduce the dosage of Renoket as well as any source of calcium.
Drug Interactions
The simultaneous administration of medicaments containing calcium (eg, acetolyte) may lead to pathological increases of the serum calcium level or intensification.
As the uremic symptoms improve under Renoket, a possible administration of aluminum hydroxide should be reduced. Pay attention to a reduction of serum phosphate.
In order not to interfere with absorption, do not take drugs together with Renoket that form sparingly soluble compounds with calcium [eg, tetracyclines, quinolone (eg, ciprofloxacin and norfloxacin), iron-, fluoride- and estramustin-containing drugs]. Between the intake of Renoket and drugs from the mentioned categories, a period of at least 2 hrs should pass. The susceptibility towards heart/cardiac-active glycosides and hence, also the risk of arrhythmia increases with the rise of the blood calcium concentration.
As the uremic symptoms improve under Renoket, a possible administration of aluminum hydroxide should be reduced. Pay attention to a reduction of serum phosphate.
In order not to interfere with absorption, do not take drugs together with Renoket that form sparingly soluble compounds with calcium [eg, tetracyclines, quinolone (eg, ciprofloxacin and norfloxacin), iron-, fluoride- and estramustin-containing drugs]. Between the intake of Renoket and drugs from the mentioned categories, a period of at least 2 hrs should pass. The susceptibility towards heart/cardiac-active glycosides and hence, also the risk of arrhythmia increases with the rise of the blood calcium concentration.
Storage
Store at temperatures not exceeding 30°C. Protect from light.
Action
Pharmacology: Pharmacokinetics: In normal individuals, there is an increase in the plasma level of ketoanalogues, 10 min after oral ingestion. These levels reach values that are approximately 5 times higher than the initial level. Peak levels are reached within 20-60 min and normal levels are reached again after 90 min. Gastrointestinal absorption is thus very rapid. In the plasma, a simultaneous increase in levels of the ketoanalogue and the corresponding amino acid show that transamination of the ketoanalogues is very rapid. Due to the natural pathways of disposal of α-ketonic acids in the organism, it is probable that exogenous intakes are very rapidly integrated into metabolic cycles. Ketoacids follow the same catabolic pathways as the classical amino acids.
Therapeutic Action: Normalizes metabolic process, promotes recycling product exchange. Reduces ion concentration of potassium, magnesium and phosphate.
Therapeutic Action: Normalizes metabolic process, promotes recycling product exchange. Reduces ion concentration of potassium, magnesium and phosphate.
MedsGo Class
Other Drugs Acting on the Genito-Urinary System
Features
Drug Ingredients
- Amino Acid
- Ketoanalogues
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Ketoanalogues / Essential Amino Acids
Registration Number
DRP-5521
Drug Classification
Prescription Drug (RX)
Questions and Answers about RENOKET Ketoanalogues / Essential Amino Acids Film-Coated Tablet 1's
Questions
