NEFROTEIN Ketoanalogues / Essential Amino Acids Film-Coated Tablet 1's
Indications/Uses
Dosage/Direction for Use
Four to eight tablets, three times a day.
1 tablet/5 kg body weight per day.
Should be taken with food (Swallow whole, do not chew/crush).
Administration
Contraindications
Hypercalcemia.
Disturbed amino acid metabolism.
Caution use for patients with phenylketonuria.
Warnings
Special Precautions
Use In Pregnancy & Lactation
Adverse Reactions
If the hypercalcemia persists, reduce the dosage of Ketoanalogues + Essential amino acids (Nefrotein) as well as any source of calcium.
Drug Interactions
As the uraemic symptoms improve under Ketoanalogues + Essential amino acids (Nefrotein), a possible administration of aluminum hydroxide should be reduced. Pay attention to a reduction of serum phosphate. In order not to interfere with absorption, do not take drugs together with Ketoanalogues + Essential amino acids (Nefrotein) that form sparingly soluble compounds with calcium (e.g. tetracyclines, quinolone e.g. ciprofloxacin and norfloxacin, iron-, fluoride- and estramustin-containing drugs). Between the intake of Ketoanalogues + Essential amino acids (Nefrotein) and drugs from the mentioned categories, a period of at least 2 hours should pass. The susceptibility towards heart/cardiac-active glycosides and hence also the risk of arrhythmia increases with the rise of blood calcium concentration.
Storage
Action
Pharmacokinetics: In normal individuals, there is an increase in plasma level of ketoanalogues, 10 minutes after oral ingestion. These levels reach values that are approximately 5 times higher than the initial level. Peak levels are reached within 20-60 min, and normal levels are reached again after 90 min. Gastrointestinal absorption is thus very rapid. In the plasma, a simultaneous increase in levels of the ketoanalogue and the corresponding amino acid show that transamination of the ketoanalogues is very rapid. Due to the natural pathways of disposal of α-ketonic acids in the organism, it is probable that exogenous intakes are very rapidly integrated into metabolic cycles. Ketoacids follow the same catabolic pathways as the classical amino acids.
MedsGo Class
Features
- Amino Acid
- Ketoanalogues