ENDOPROST Carboprost Tromethamine 125mcg / 0.5mL Solution for Injection 0.5mL 5's
RXDRUG-DR-XY44686
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Carboprost Tromethamine (Endoprost) is indicated for the treatment of post partum haemorrhage especially due to uterine atony which has not responded to conventional methods of management. Carboprost Tromethamine (Endoprost) may be used prophylactically by intramuscular injection at the birth of anterior shoulder in patients with following risks: Grand multipara; Pre-eclampsia; Rapid or prolonged labour; Placental abnormalities; Previous uterine surgery; History of PPH; History of retained placenta; Over distention of uterus.
Dosage/Direction for Use
Prophylactic treatment for the control of post partum haemorrhage: Carboprost Tromethamine (Endoprost) at a dose equivalent to 125 mcg-250 mcg should be given intramuscularly at the delivery of the anterior shoulder of fetus.
Refractory Post Partum Haemorrhage: Carboprost Tromethamine (Endoprost) as a dose equivalent to 250 mcg should be given by deep intramuscular injection at interval of about 90 minutes. The interval may be reduced if necessary but should not be less than 15 minutes. The total dose should not exceed 2000 mcg (8 vials of 250 mcg).
Refractory Post Partum Haemorrhage: Carboprost Tromethamine (Endoprost) as a dose equivalent to 250 mcg should be given by deep intramuscular injection at interval of about 90 minutes. The interval may be reduced if necessary but should not be less than 15 minutes. The total dose should not exceed 2000 mcg (8 vials of 250 mcg).
Contraindications
Hypersensitivity to Carboprost Tromethamine.
Acute pelvic inflammatory disease.
Patients with active cardiac, pulmonary, renal or hepatic disease.
Acute pelvic inflammatory disease.
Patients with active cardiac, pulmonary, renal or hepatic disease.
Special Precautions
Carboprost Tromethamine (Endoprost) should be administered cautiously in patients with a history of asthma, hypo or hypertension, cardiovascular, renal or hepatic disease, anemia, jaundice, diabetes or epilepsy.
Carboprost Tromethamine (Endoprost) is not recommended in patients having chorioamnionitis during labour as it may have an inhibitory effect on Carboprost activity.
Carboprost Tromethamine (Endoprost) should be used with caution in patients with compromised or scarred uterus.
Carboprost Tromethamine (Endoprost) is not recommended in patients having chorioamnionitis during labour as it may have an inhibitory effect on Carboprost activity.
Carboprost Tromethamine (Endoprost) should be used with caution in patients with compromised or scarred uterus.
Adverse Reactions
The frequent adverse effects observed are due to its contractile effect on smooth muscle, which are transient and reversible on cessation of therapy. These include vomiting, diarrhea, hyperpyrexia and flushing. The incidences of these common side effects during high dose treatment of Carboprost Tromethamine (Endoprost) can be minimized by pretreatment or co-administration of antiemetic and antidiarrheal drugs.
Storage
Should be stored in refrigerator (2-8ºC). Do not freeze.
Action
Pharmacology: Carboprost Tromethamine is a uterine stimulant and is used for the control of post partum haemorrhage (PPH). Carboprost Tromethamine when administered as an intramuscular injection arrests intractable atonic post partum haemorrhage by inducing myometrial contractions. This haemostasis produced by Carboprost Tromethamine at the site of palacentation minimizes the thirds stage blood loss and thereby reduces the maternal mortality and morbidity. Also, Carboprost Tromethamine when administered prophylactically at the time of labour because of its uterine stimulant activity it complements the physiological processes during labour, resulting in reduction of the duration of third stage and hence minimize post partum blood loss.
MedsGo Class
Drugs Acting on the Uterus
Features
Brand
Endoprost
Full Details
Dosage Strength
125 mcg / 0.5 ml
Drug Ingredients
- Carboprost
Drug Packaging
Solution for Injection (I.M.) 0.5ml x 5's
Generic Name
Carboprost Tromethamine
Dosage Form
Solution for Injection (I.M.)
Registration Number
DR-XY44686
Drug Classification
Prescription Drug (RX)
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