AMINOLOG Ketoanalogues Essential Amino Acids Film-Coated Tablet 1's
Indications/Uses
Dosage/Direction for Use
For oral use.
Or as prescribed by the physician.
Duration of application: The product can be administered as long as the glomerular filtration rate (GFR) is below 25 mL/min, and concomitantly, dietary protein is restricted to 40 g/day or less (adult).
Administration
Contraindications
Hypercalcaemia.
Disturbed amino acid metabolism.
Special Precautions
Drug Interactions
Storage
Action
AMINOLOG allows the intake of essential amino acids while minimizing the amino-nitrogen intake. Following ingestion, the ketoanalogues are transaminated by taking nitrogen from non-essential amino acids, thereby decreasing the formation of urea by re-using the amino group. The levels of accumulating uremic toxins are decreased. Keto- and/or hydroxy-acids do not elicit hyperfiltration of residual nephrons. Ketoacid-containing supplements have a positive influence on the renal hyperphosphatemia and secondary hyperparathyroidism and can improve renal osteodystrophy.
The use of AMINOLOG in association with a very low protein diet allows a reduced intake of nitrogen while avoiding the deleterious consequences of inadequate dietary protein intake and malnourishment.
Pharmacokinetics: Bioavailability: In normal individuals, there is an increase in the plasma level of KA, 10 min after oral ingestion. These levels reach values that are approximately 5 times higher than the initial level. Peak levels are reached within 20-60 min, and normal levels are reached again after 90 min. Gastrointestinal absorption is thus very rapid. In the plasma, a simultaneous increase in levels of the KA and the corresponding amino acid show that transamination of the KA is very rapid. Due to the natural pathways of disposal of α-ketonic acids in the organism, it is probable that exogenous intakes are very rapidly integrated into metabolic cycles. Ketoacids follow the same catabolic pathways as the classical amino acids.
MedsGo Class
Features
- Amino Acid
- Ketoanalogues