VOMETA Domperidone 5mg / 5mL Suspension 60mL
Indications/Uses
Nausea and Vomiting Due to Various Causes: Gastrointestinal intolerance due to anti-cancer chemotherapy, digitalis, L-dopa and others including radiotherapy; abdominal, gastrointestinal, hepatobiliary, peritoneal and renal pathology; pediatric pathology due to functional disorders (pylorospasm, cyclic vomiting) or organic disorders, intoxication by infection, dietary or acetonemia.
Dosage/Direction for Use
Children: Suspension: 2.5 mg/10 kg body weight, 3 times daily before meals.
Nausea and Vomiting: Adults and Elderly: 10-20 mg, 3-4 times daily, with 4-8 hours interval.
Children: Suspension: 2.5-5 mg/10 kg body weight or 0.3-0.6 mL/5 kg body weight, 3-4 times daily before meals.
Drops: 0.2-0.4 mg/kg body weight 3-4 times daily. Doses should be taken with 4-8 hrs interval.
Overdosage
Treatment: There is no specific antidote for overdosage, but activated charcoal can be given and it is better to observe and give symptomatic treatment.
Administration
Contraindications
Domperidone cannot be administered if gastric motility causes bleeding, mechanical obstruction or gastrointestinal perforation. Domperidone is also contraindicated in patients with prolactinoma and tumor hypohyloma which produce prolactin.
Use in pregnancy & lactation: Not recommended in pregnant women or nursing mothers.
Special Precautions
Domperidone is not recommended for long-term treatment.
Use with caution in patients with hepatic impairment.
Use In Pregnancy & Lactation
Adverse Reactions
Drug Interactions
Domperidone can be administered concomitantly with neurologic drugs with no potentiation effects, dopaminergic agonists (bromocriptine, L-dopa), whereas peripheral effects eg, gastric disorders, nausea and vomiting can be decreased without reducing the central activity.
Storage
Action
Pharmacology: Domperidone is a benzimidazole derivative with prokinetic and antiemetic effects, with the latter effect very similar to metoclopramide. Extrapyramidal reactions are rare as domperidone generally does not cross the blood-brain barrier. Oral administration prolongs the contraction of the anthrum and duodenum, increases gastric emptying and pressure of lower esophagus sphincter. There is no side effect to gastric secretion.
MedsGo Class
Features
- Domperidone