DOCTRA Rabeprazole Sodium 20mg Enteric-Coated Tablet 1's
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Features
- Rabeprazole
Description
Indications/Uses
Dosage/Direction for Use
Duodenal ulcer: 20 mg/day in the morning for 4 weeks, continued for further 4 weeks if not fully healed.
Ulcerative or Erosive Gastroesophageal reflux disease: 20 mg once daily for 4-8 weeks; maintenance 10-20 mg daily; symptomatic treatment in the absence of oesophagitis, 10 mg daily for up to 4 weeks, then 10 mg daily when required.
Duodenal and benign gastric ulcer associated with: 20 mg twice daily + clarithromycin 500 mg twice daily and amoxicillin 1 gram twice daily for 7 days.
Overdosage
Administration
Contraindications
Warnings
Special Precautions
Monitor gastric malignancy.
Use In Pregnancy & Lactation
Nursing Mother: A decision should be made to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.
Adverse Reactions
Drug Interactions
Rabeprazole-Digoxin co-administration results in increased through digoxin levels in normal subjects.
Storage
Action
Rabeprazole sodium irreversibly inhibits proton pump activity and decreases gastric acid secretion. Rabeprazole produces fastest acid suppression and helps in mucin synthesis.
Pharmacokinetics: Peak plasma-rabeprazole concentrations reach about 3.5 hours after a dose by mouth. The oral bioavailability is about 52% with the enteric-coaled tablet formulation, because of first-pass metabolism, and does not appear lo vary after single or repealed doses. Rabeprazole is 97% bound lo plasma proteins. It is extensively metabolized in the liver by cytochrome P450 isoenzymes CYP2C19 and CYP3A4 lo the thioether, thioether carboxylic acid, sulfone, and desmethyl thioether. Metabolites are excreted principally in the urine about 90% with the remainder in the feces. The plasma half-life is about 1 hour, increased two or threefold in hepatic impairment, 1.6 times in CYP2C19 slow metabolizers and by 30% in the elderly.