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Indications/Uses
Management of glaucoma, epilepsy, CHF & induced edema.
Dosage/Direction for Use
Chronic Simple Glaucoma: 250 mg-1 g/24 hrs in divided doses.
Secondary Glaucoma/Preoperative Treatment of Some Cases of Acute Congestive Glaucoma: 250 mg 4 hrly. In some acute cases, an initial dose of 500 mg then 125-250 mg 4 hrly.
Epilepsy: 8-30 mg/kg in divided doses. Max: 375-1000 mg daily.
Congestive Heart Failure: 250-375 mg once daily in the morning.
Drug-induced Edema: 250-375 mg once a day for 1-2 days, alternating with a day of rest.
Secondary Glaucoma/Preoperative Treatment of Some Cases of Acute Congestive Glaucoma: 250 mg 4 hrly. In some acute cases, an initial dose of 500 mg then 125-250 mg 4 hrly.
Epilepsy: 8-30 mg/kg in divided doses. Max: 375-1000 mg daily.
Congestive Heart Failure: 250-375 mg once daily in the morning.
Drug-induced Edema: 250-375 mg once a day for 1-2 days, alternating with a day of rest.
Administration
Should be taken with food.
Contraindications
Depressed sodium and/or potassium blood serum levels, marked kidney or liver disease; suprarenal gland failure; hyperchloraemic acidosis; cirrhosis. Long-term administration in patients with chronic non-congestive angle-closure glaucoma.
Special Precautions
Pulmonary obstruction or emphysema where alveolar ventilation may be impaired. Rapid ascent to high altitude. Pregnancy, lactation.
Adverse Reactions
Paraesthesia; loss of appetite; hearing dysfunction; or tinnitus; taste alteration, Gl disturbances; polyuria; drowsiness and confusion; acidosis (long-term therapy), transient myopia. Occasionally, urticaria; melaena; haematuria; glycosuria; hepatic insufficiency; flaccid paralysis; photosensitivity; convulsion. Sulfonamide-type reactions.
Storage
Store at temperature not exceeding 30°C. Protect from light.
Action
Carbonic anhydrase inhibitor.
Pharmacokinetics: Acetazolamide is fairly rapidly absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 2 hrs after administration by mouth. It has been estimated to have a plasma half-life of about 3-6 hrs. It is tightly bound to carbonic anhydrase and high concentrations are present in tissues containing this enzyme, particularly RBCs and the renal cortex; it is highly bound to plasma proteins. It is excreted unchanged in the urine.
Pharmacokinetics: Acetazolamide is fairly rapidly absorbed from the gastrointestinal tract with peak plasma concentrations occurring about 2 hrs after administration by mouth. It has been estimated to have a plasma half-life of about 3-6 hrs. It is tightly bound to carbonic anhydrase and high concentrations are present in tissues containing this enzyme, particularly RBCs and the renal cortex; it is highly bound to plasma proteins. It is excreted unchanged in the urine.
MedsGo Class
Antiglaucoma Preparations / Diuretics
Features
Dosage Strength
250 mg
Drug Ingredients
- Acetazolamide
Drug Packaging
Tablet 1's
Generic Name
Acetazolamide
Registration Number
DRP-1877
Drug Classification
Prescription Drug (RX)
Questions and Answers about CETAMID Acetazolamide 250mg Tablet 1's
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