MOVELAX Lactulose 3.3g / 5mL Syrup 120mL
RXDRUG-DR-XY37503-120
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FDA-licensed Pharmacies
Features
Brand
Movelax
Full Details
Dosage Strength
3.3g / 5ml
Drug Ingredients
- Lactulose
Drug Packaging
Syrup 120ml
Generic Name
Lactulose
Dosage Form
Syrup
Registration Number
DR-XY37503
Drug Classification
Prescription Drug (RX)
Description
Indications/Uses
Treatment of chronic and habitual constipation.
Prevention and treatment of portal systemic encephalopathy (PSE) including the stages of hepatic pre-coma and coma.
For patients with hemorrhoids, after colon/anal surgery or other conditions where a soft stool is beneficial.
Prevention and treatment of portal systemic encephalopathy (PSE) including the stages of hepatic pre-coma and coma.
For patients with hemorrhoids, after colon/anal surgery or other conditions where a soft stool is beneficial.
Dosage/Direction for Use
Treatment of chronic and habitual constipation and for patients who will benefit from soft stools: (see table.)
Prevention and treatment of portal systemic encephalopathy: Initial Dose in Adults and Elderly: 30-50 mL three times daily.
Subsequent doses should be adjusted to produce 2 or 3 soft stools daily.
Prevention of hepatic coma: Initial Dose in Adults: 25 mL three times daily.
Subsequent doses should be adjusted to obtain soft stools.
Subsequent doses should be adjusted to produce 2 or 3 soft stools daily.
Prevention of hepatic coma: Initial Dose in Adults: 25 mL three times daily.
Subsequent doses should be adjusted to obtain soft stools.
Administration
May be taken with or without food: May be taken w/ meals to reduce GI discomfort. Dilute w/ water, milk, or fruit juice to improve taste.
Special Precautions
Lactulose may cause accumulation of hydrogen gas in significant concentrations, which in the presence of an electrical spark may theoretically result in an explosive reaction. Patients treated with lactulose who may be required to undergo electrocautery procedures during proctoscopy or colonoscopy should have a thorough bowel cleansing with a nonfermentable solution prior to these procedures.
Lactulose contains some free galactose and lactose. Diabetic patients and those with lactose intolerance should use lactulose with caution since blood glucose may be elevated, usually after extended use.
Patients should consult their physicians if any unusual diarrhea occurs.
Elderly or debilitated patients using lactulose for more than 6 months should have their serum electrolytes (i.e., potassium, chloride, carbon dioxide) periodically measured.
Lactulose contains some free galactose and lactose. Diabetic patients and those with lactose intolerance should use lactulose with caution since blood glucose may be elevated, usually after extended use.
Patients should consult their physicians if any unusual diarrhea occurs.
Elderly or debilitated patients using lactulose for more than 6 months should have their serum electrolytes (i.e., potassium, chloride, carbon dioxide) periodically measured.
Adverse Reactions
Initial dosing of lactulose may cause flatulence and abdominal cramps which are generally transient. Excessive dosage can lead to diarrhea with excessive loss of water and electrolytes (particularly potassium and sodium). Hypernatremia, nausea and vomiting have also been reported.
Some consider the taste unpleasant. This can be minimized by dilution of water, fruit juice, or milk, or by mixing the dose with food.
Some consider the taste unpleasant. This can be minimized by dilution of water, fruit juice, or milk, or by mixing the dose with food.
Action
Laxative.
Pharmacology: Lactulose is a synthetic disaccharide osmotic laxative containing galactose and fructose. Colonic bacteria break lactulose primarily to lactic and acetic acid which results in an increased osmotic effect and slight acidification of the colonic contents. This results in an increased fecal bulk, softened stools and shortened transit time. It may take 48 hours before an effect is obtained.
Lactulose exerts its effect only in the colon. It decreases blood ammonia concentrations by acidifying the contents of the bowel reducing intraluminal pH to below 5. This reduces the degree of portal systemic encephalopathy since the absorption of ammonium ions and other toxic nitrogenous compounds into the blood is decreased.
Pharmacokinetics: Bioavailability: Lactulose is poorly absorbed from the gastrointestinal tract after oral administration. No enzyme present in human gastrointestinal tissue is capable of hydrolysis of this disaccharide. Lactulose reaches the colon virtually unchanged with less than 2% being absorbed by non-mediated diffusion. Urinary excretion is less than or equal to 3% and is essentially complete within 24 hours.
Pharmacology: Lactulose is a synthetic disaccharide osmotic laxative containing galactose and fructose. Colonic bacteria break lactulose primarily to lactic and acetic acid which results in an increased osmotic effect and slight acidification of the colonic contents. This results in an increased fecal bulk, softened stools and shortened transit time. It may take 48 hours before an effect is obtained.
Lactulose exerts its effect only in the colon. It decreases blood ammonia concentrations by acidifying the contents of the bowel reducing intraluminal pH to below 5. This reduces the degree of portal systemic encephalopathy since the absorption of ammonium ions and other toxic nitrogenous compounds into the blood is decreased.
Pharmacokinetics: Bioavailability: Lactulose is poorly absorbed from the gastrointestinal tract after oral administration. No enzyme present in human gastrointestinal tissue is capable of hydrolysis of this disaccharide. Lactulose reaches the colon virtually unchanged with less than 2% being absorbed by non-mediated diffusion. Urinary excretion is less than or equal to 3% and is essentially complete within 24 hours.
MedsGo Class
Cholagogues, Cholelitholytics & Hepatic Protectors / Laxatives, Purgatives
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