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RXDRUG-DR-XY42757-1pc

DULXATIVE Bisacodyl 10mg Suppository 1's

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Description

Indications/Uses

Used for the treatment of constipation and for bowel evacuation before investigational procedures or surgery.
 

Dosage/Direction for Use

For constipation, bisacodyl is given in usual doses of 5 to 15 mg daily as enteric-coated tablets administered at night or 10 mg suppository or enema administered in the morning. Doses of 10 up to 20 mg are given by mouth for complete bowel evacuation, followed by 10 mg as suppository the next morning.
Children under 10 years age may be given 5 mg rectally in the morning for constipation; those over 4 years may alternatively be given 5 mg by mouth at night. For bowel evacuation the dose is 15 mg by mouth the night before and 5 mg rectally the morning of the procedure. Children over 10 years of age may be given doses similar to those for adults.
Bisacodyl has been administered with a barium sulfate enema before radiographic examination of the colon. A complex of bisacodyl with tannic acid is generally used in a dose equivalent to 1.5 to 3 mg of bisacodyl dissolved in 1 liter of barium sulfate suspension. The total dose for one procedure should not exceed 4.5 mg bisacodyl and no more than 6 mg should be administered in 72 hours.
Directions for use: 1. Wash hands thoroughly before and after insertion of Bisacodyl suppository.
2. Clean the area around the rectum with mild soap and warm water, and rinse thoroughly. Gently dry by patting or blotting with toilet issue or soft cloth.
3. Detach one suppository from the strip and hold the suppository in an upright position and carefully peel the wrapper evenly on both sides. Avoid excessive handling as the suppository is designed to melt at body temperature.
4. Position the patient flat on back or on one side with anal opening exposed.
5. Gently insert the suppository well in to the rectum; use fingertip to complete insertion.
6. If necessary, hold the buttocks together for 30-60 seconds to keep suppository in place.
7. If suppository is soft, hold the wrapper under cold water for solidification and then use the suppository.
 

Contraindications

Bisacodyl and other stimulant laxatives may cause abdominal discomfort such as colic cramps. Prolonged used or overdosage can result in diarrhea with excessive loss of water and electrolytes, particularly potassium; there is also the possibility developing an atonic non-functioning colon.
 

Warnings

It may cause abdominal discomfort such as colic or cramps. Prolonged use or overdosage can result in diarrhea with excessive loss of water and electrolytes, particularly potassium.
When administered rectally, sometimes causes irritation and repeated use may cause proctitis or sloughing of the epithelium.
 

Special Precautions

As with other laxatives, prolonged use should be avoided. Bisacodyl should not be given to patients with intestinal obstruction or acute abdominal conditions such as appendicitis; care should also be taken in patients with inflammatory bowel disease. It should not be used in patients with severe dehydration. The suppositories should be preferably avoided in patients with anal fissures, proctitis, or ulcerated hemorrhoids.
 

Adverse Reactions

Bisacodyl may cause abdominal discomfort such as colic or cramps. Prolonged use or overdosage can result in diarrhea with excessive loss of water and electrolytes, particularly potassium; there is also the possibility of developing an atonic non-functioning colon. When administered rectally bisacodyl sometimes causes irritation and repeated use may cause proctitis or sloughing of the epithelium.
 

Storage

Store at temperatures not exceeding 25°C.
 

Action

Pharmacology: Bisacodyl is diphenylmethane stimulant laxative used for the treatment of constipation and for bowel evacuation before investigational procedures or surgery. Its action is mainly in the large intestines and it is usually effective within 6 to 12 hours following administration by mouth and within 15 to 60 minutes following rectal administration. Bisacodyl tablets should be swallowed whole and should not be taken within one hour of milk or antacids.
Pharmacokinetics: Following administration of bisacodyl by mouth or rectally, it is converted to the active desacetyl metabolite bis (p-hydroxyphenyl) pyridyl-2-methane by intestinal and bacterial enzymes. Absorption from the gastrointestinal tract is minimal with enteric-coated tablets or suppositories; the small amount. Absorbed is excreted in the urine as the glucuronide. Bisacodyl is mainly excreted in the feces.
 

MedsGo Class

Laxatives, Purgatives

Features

Brand
Dulxative
Full Details
Dosage Strength
10 mg
Drug Ingredients
  • Bisacodyl
Drug Packaging
Suppository 1's
Generic Name
Bisacodyl
Dosage Form
Suppository
Registration Number
DR-XY42757
Drug Classification
Prescription Drug (RX)
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