JARDIANCE DUO Empagliflozin / Metformin 12.5mg / 500mg - 1 Tablet

Indications / Uses

JARDIANCE DUO 12.5mg / 500mg is used for controlling blood sugar levels in adults with type 2 diabetes mellitus alongside proper diet and exercise. This dual-action medication combines two active ingredients to improve glycemic control when metformin or empagliflozin alone is insufficient. It also reduces cardiovascular death risk in adults with type 2 diabetes and established cardiovascular disease.

Formulation / Ingredients
JARDIANCE DUO 12.5mg / 500mg contains: Empagliflozin 12.5mg + Metformin Hydrochloride 500mg

Side Effects

JARDIANCE DUO 12.5mg / 500mg common side effects include: urinary tract infections, female genital mycotic infections, volume depletion symptoms (low blood pressure, dizziness), and hypoglycemia when combined with insulin/sulfonylureas. Gastrointestinal reactions like nausea, vomiting, or diarrhea may occur due to the metformin component. Serious risks include lactic acidosis, ketoacidosis (evidenced by difficulty breathing, nausea, vomiting), and Fournier's gangrene.

Directions and Dosage

• Adults (18+ years): 1 tablet twice daily with meals. Maximum daily dose: Empagliflozin 25mg + Metformin 2000mg.

Not recommended for children under 18. Renal function must be assessed before initiation: Do not use if eGFR below 30 mL/min/1.73m². Discontinue if dehydration occurs. Treatment duration is long-term under regular monitoring.

Contraindications

Severe renal impairment (eGFR <30 mL/min/1.73m²), ketoacidosis, hypersensitivity to components, and acute/chronic metabolic acidosis. Avoid in dialysis patients.

Use in Pregnancy and Lactation

Not recommended during pregnancy due to potential fetal risks. Discontinue immediately if pregnancy occurs. Contraindicated during breastfeeding as components pass into breast milk.

Special Precautions

• Monitor renal function before treatment and annually
• Assess volume status and correct dehydration before initiation
• Increased risk of ketoacidosis with acute medical conditions
• Higher UTI and genital infection risk requires prompt symptom monitoring

Is it safe to take it with other medications?

Increased hypoglycemia risk when combined with insulin or sulfonylureas. Carbonic anhydrase inhibitors may raise lactic acidosis risk. Diuretics can intensify volume depletion effects. Always disclose current medications before use.

How should I store it?

Store below 30°C in original packaging. Protect from moisture and light. Keep container tightly closed. Do not use if packaging is compromised.Used For

Type 2 Diabetes

Age

Adults only