Indications/Uses
50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is indicated for the treatment of patients with diabetes mellitus who require insulin for the maintenance of normal glucose homeostasis.
Dosage/Direction for Use
The dosage should be determined by the physician, according to the requirement of the patient.
50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 Kwikpen) may be given shortly before meals. When necessary, 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) can be given soon after meals. 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) should only be given by subcutaneous injection. Under no circumstances should 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) be given intravenously.
Subcutaneous administration should be in the upper arms, thighs, buttocks, or abdomen. Use of injection sites should be rotated so that the same site is not used more than approximately once a month.
When administered subcutaneously care should be taken when injecting 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) to ensure that a blood vessel has not been entered. After injection, the site of injection should not be massaged. Patients must be educated to use the proper injection techniques.
The rapid onset and early peak of activity of Insulin lispro (Humalog) itself is observed following the subcutaneous administration of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen). This allows 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) to be given very close to mealtime. The duration of action of the insulin lispro protamine suspension component of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is similar to that of a basal insulin.
The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with all insulin preparations, the duration of action of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is dependent on dose, site of injection, blood supply, temperature, and physical activity.
50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 Kwikpen) may be given shortly before meals. When necessary, 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) can be given soon after meals. 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) should only be given by subcutaneous injection. Under no circumstances should 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) be given intravenously.
Subcutaneous administration should be in the upper arms, thighs, buttocks, or abdomen. Use of injection sites should be rotated so that the same site is not used more than approximately once a month.
When administered subcutaneously care should be taken when injecting 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) to ensure that a blood vessel has not been entered. After injection, the site of injection should not be massaged. Patients must be educated to use the proper injection techniques.
The rapid onset and early peak of activity of Insulin lispro (Humalog) itself is observed following the subcutaneous administration of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen). This allows 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) to be given very close to mealtime. The duration of action of the insulin lispro protamine suspension component of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is similar to that of a basal insulin.
The time course of action of any insulin may vary considerably in different individuals or at different times in the same individual. As with all insulin preparations, the duration of action of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is dependent on dose, site of injection, blood supply, temperature, and physical activity.
Overdosage
Insulins have no specific overdose definitions because serum glucose concentrations are a result of complex interactions between insulin levels, glucose availability and other metabolic processes. Hypoglycemia may occur as a result of an excess of insulin activity relative to food intake and energy expenditure.
Hypoglycemia may be associated with listlessness, confusion, palpitations, headache, sweating and vomiting.
Mild hypoglycemic episodes will respond to oral administration of glucose or other sugar or saccharated products.
Correction of moderately severe hypoglycemia can be accomplished by intramuscular or subcutaneous administration of glucagon, followed by oral carbohydrate when the patient recovers sufficiently. Patients who fail to respond to glucagon must be given glucose solution intravenously.
If the patient is comatose, glucagon should be administered intramuscularly or subcutaneously. However, glucose solution must be given intravenously if glucagon is not available or if the patient fails to respond to glucagon. The patient should be given a meal as soon as consciousness is recovered.
Sustained carbohydrate intake and observation may be necessary because hypoglycemia may recur after apparent clinical recovery.
Hypoglycemia may be associated with listlessness, confusion, palpitations, headache, sweating and vomiting.
Mild hypoglycemic episodes will respond to oral administration of glucose or other sugar or saccharated products.
Correction of moderately severe hypoglycemia can be accomplished by intramuscular or subcutaneous administration of glucagon, followed by oral carbohydrate when the patient recovers sufficiently. Patients who fail to respond to glucagon must be given glucose solution intravenously.
If the patient is comatose, glucagon should be administered intramuscularly or subcutaneously. However, glucose solution must be given intravenously if glucagon is not available or if the patient fails to respond to glucagon. The patient should be given a meal as soon as consciousness is recovered.
Sustained carbohydrate intake and observation may be necessary because hypoglycemia may recur after apparent clinical recovery.
Administration
Should be taken with food: Administer shortly before or w/in 15 min after meals.
Contraindications
Hypersensitivity to insulin lispro or to any of the excipients.
Hypoglycemia.
Hypoglycemia.
Special Precautions
Under no circumstances should 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) be given intravenously.
Transferring a patient to another type or brand of insulin should be done under strict medical supervision. Changes in strength, brand (manufacturer), type (regular, NPH, lente, etc.), species (animal, human, human insulin analogue), and/or method of manufacture (recombinant DNA versus animal-source insulin) may result in the need for a change in dosage.
Conditions which may make the early warning symptoms of hypoglycemia different or less pronounced include long duration of diabetes, intensified insulin therapy, diabetic nerve disease or medications such as beta-blockers.
A few patients who have experienced hypoglycemic reactions after transfer from animal-source insulin to human insulin have reported that the early warning symptoms of hypoglycemia were less pronounced or different from those experienced with their previous insulin. Uncorrected hypoglycemic or hyperglycemic reactions can cause loss of consciousness, coma, or death.
The use of dosages which are inadequate or discontinuation of treatment, especially in insulin-dependent diabetics, may lead to hyperglycemia and diabetic ketoacidosis; conditions which are potentially lethal.
Insulin requirements may be reduced in the presence of renal impairment. Insulin requirements may be reduced in patients with hepatic impairment due to reduced capacity for gluconeogenesis and reduced insulin breakdown; however, in patients with chronic hepatic impairment, an increase in insulin resistance may lead to increased insulin requirements.
Insulin requirements may be increased during illness or emotional disturbances.
Adjustment of dosage may also be necessary if patients undertake increased physical activity or change their usual diet. Exercise taken immediately after a meal may increase the risk of hypoglycemia.
Administration of insulin lispro to children below 12 years of age should be considered only in case of an expected benefit when compared to regular insulin.
Combination of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) with pioglitazone: Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors for development of cardiac heart failure. This should be kept in mind, if treatment with the combination of pioglitazone and 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is considered. If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and edema. Pioglitazone should be discontinued, if any deterioration in cardiac symptoms occurs.
Effects on ability to drive and use machines: The patient's ability to concentrate and react may be impaired as a result of hypoglycemia. This may constitute a risk in situations where these abilities are of special importance (e.g. driving a car or operating machinery).
Patients should be advised to take precautions to avoid hypoglycemia whilst driving, this is particularly important in those who have reduced or absent awareness of the warning signs of hypoglycemia or have frequent episodes of hypoglycemia. The advisability of driving should be considered in these circumstances.
Transferring a patient to another type or brand of insulin should be done under strict medical supervision. Changes in strength, brand (manufacturer), type (regular, NPH, lente, etc.), species (animal, human, human insulin analogue), and/or method of manufacture (recombinant DNA versus animal-source insulin) may result in the need for a change in dosage.
Conditions which may make the early warning symptoms of hypoglycemia different or less pronounced include long duration of diabetes, intensified insulin therapy, diabetic nerve disease or medications such as beta-blockers.
A few patients who have experienced hypoglycemic reactions after transfer from animal-source insulin to human insulin have reported that the early warning symptoms of hypoglycemia were less pronounced or different from those experienced with their previous insulin. Uncorrected hypoglycemic or hyperglycemic reactions can cause loss of consciousness, coma, or death.
The use of dosages which are inadequate or discontinuation of treatment, especially in insulin-dependent diabetics, may lead to hyperglycemia and diabetic ketoacidosis; conditions which are potentially lethal.
Insulin requirements may be reduced in the presence of renal impairment. Insulin requirements may be reduced in patients with hepatic impairment due to reduced capacity for gluconeogenesis and reduced insulin breakdown; however, in patients with chronic hepatic impairment, an increase in insulin resistance may lead to increased insulin requirements.
Insulin requirements may be increased during illness or emotional disturbances.
Adjustment of dosage may also be necessary if patients undertake increased physical activity or change their usual diet. Exercise taken immediately after a meal may increase the risk of hypoglycemia.
Administration of insulin lispro to children below 12 years of age should be considered only in case of an expected benefit when compared to regular insulin.
Combination of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) with pioglitazone: Cases of cardiac failure have been reported when pioglitazone was used in combination with insulin, especially in patients with risk factors for development of cardiac heart failure. This should be kept in mind, if treatment with the combination of pioglitazone and 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is considered. If the combination is used, patients should be observed for signs and symptoms of heart failure, weight gain and edema. Pioglitazone should be discontinued, if any deterioration in cardiac symptoms occurs.
Effects on ability to drive and use machines: The patient's ability to concentrate and react may be impaired as a result of hypoglycemia. This may constitute a risk in situations where these abilities are of special importance (e.g. driving a car or operating machinery).
Patients should be advised to take precautions to avoid hypoglycemia whilst driving, this is particularly important in those who have reduced or absent awareness of the warning signs of hypoglycemia or have frequent episodes of hypoglycemia. The advisability of driving should be considered in these circumstances.
Use In Pregnancy & Lactation
Data on a large number of exposed pregnancies do not indicate any adverse effect of insulin lispro on pregnancy or on the health of the fetus/newborn.
It is essential to maintain good control of the insulin-treated (insulin-dependent or gestational diabetes) patient throughout pregnancy. Insulin requirements usually fall during the first trimester and increase during the second and third trimesters. Patients with diabetes should be advised to inform their doctor if they are pregnant or are contemplating pregnancy. Careful monitoring of glucose control, as well as general health, is essential in pregnant patients with diabetes.
Patients with diabetes who are breastfeeding may require adjustments in insulin dose, diet or both.
It is essential to maintain good control of the insulin-treated (insulin-dependent or gestational diabetes) patient throughout pregnancy. Insulin requirements usually fall during the first trimester and increase during the second and third trimesters. Patients with diabetes should be advised to inform their doctor if they are pregnant or are contemplating pregnancy. Careful monitoring of glucose control, as well as general health, is essential in pregnant patients with diabetes.
Patients with diabetes who are breastfeeding may require adjustments in insulin dose, diet or both.
Adverse Reactions
Hypoglycemia is the most frequent undesirable effect of insulin therapy that a patient with diabetes may suffer. Severe hypoglycemia may lead to loss of consciousness, and in extreme cases, death. No specific frequency for hypoglycemia is presented, since hypoglycemia is a result of both the insulin dose and other factors e.g. a patient's level of diet and exercise.
Local allergy in patients is common (1/100 to <1/10). Redness, swelling, and itching can occur at the site of insulin injection. This condition usually resolves in a few days to a few weeks. In some instances, this condition may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique. Systemic allergy, which is rare (1/10,000 to <1/1,000) but potentially more serious, is a generalised allergy to insulin. It may cause a rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Severe cases of generalized allergy may be life-threatening.
Lipodystrophy at the injection site is uncommon (1/1,000 to <1/100).
Cases of edema have been reported with insulin therapy, particularly if previous poor metabolic control is improved by intensified insulin therapy.
Reporting of suspected adverse reactions: Reporting suspected adverse reactions after authorization of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions.
Local allergy in patients is common (1/100 to <1/10). Redness, swelling, and itching can occur at the site of insulin injection. This condition usually resolves in a few days to a few weeks. In some instances, this condition may be related to factors other than insulin, such as irritants in the skin cleansing agent or poor injection technique. Systemic allergy, which is rare (1/10,000 to <1/1,000) but potentially more serious, is a generalised allergy to insulin. It may cause a rash over the whole body, shortness of breath, wheezing, reduction in blood pressure, fast pulse, or sweating. Severe cases of generalized allergy may be life-threatening.
Lipodystrophy at the injection site is uncommon (1/1,000 to <1/100).
Cases of edema have been reported with insulin therapy, particularly if previous poor metabolic control is improved by intensified insulin therapy.
Reporting of suspected adverse reactions: Reporting suspected adverse reactions after authorization of the medicinal product is important. It allows continued monitoring of the benefit/risk balance of the medicinal product. Healthcare professionals are asked to report any suspected adverse reactions.
Drug Interactions
Insulin requirements may be increased by substances with hyperglycemic activity, such as oral contraceptives, corticosteroids, or thyroid replacement therapy, danazol, beta2 stimulants (such as ritodrine, salbutamol, terbutaline).
Insulin requirements may be reduced in the presence of substances with hypoglycemic activity, such as oral hypoglycemics, salicylates (for example, acetylsalicylic acid), sulpha antibiotics, certain antidepressants (monoamine oxidase inhibitors, selective serotonin reuptake inhibitors), certain angiotensin converting enzyme inhibitors (captopril, enalapril), angiotensin II receptor blockers, beta-blockers, octreotide or alcohol.
Mixing 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) with other insulins has not been studied.
The physician should be consulted when using other medications in addition to 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) (see Precautions).
Insulin requirements may be reduced in the presence of substances with hypoglycemic activity, such as oral hypoglycemics, salicylates (for example, acetylsalicylic acid), sulpha antibiotics, certain antidepressants (monoamine oxidase inhibitors, selective serotonin reuptake inhibitors), certain angiotensin converting enzyme inhibitors (captopril, enalapril), angiotensin II receptor blockers, beta-blockers, octreotide or alcohol.
Mixing 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) with other insulins has not been studied.
The physician should be consulted when using other medications in addition to 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) (see Precautions).
Caution For Usage
Incompatibilities: Mixing 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) with other insulins has not been studied. In the absence of compatibility studies, this medicinal product must not be mixed with other medicinal products.
Special precautions for disposal and other handling: Any unused product or waste material should be disposed of in accordance with local requirements.
Instructions for use and handling: To prevent the possible transmission of disease, each pen must be used by one patient only, even if the needle is changed.
The KwikPen should be rotated in the palms of the hands ten times and inverted 180° ten times immediately before use to resuspend the insulin until it appears uniformly cloudy or milky. If not, repeat the procedure until contents are mixed. Cartridges contain a small glass bead to assist mixing. Do not shake vigorously as this may cause frothing which may interfere with the correct measurement of dose.
The cartridges should be examined frequently and should not be used if clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving a frosted appearance.
Handling of the prefilled pen: Before using the KwikPen the user manual included in the package leaflet must be read carefully. The KwikPen has to be used as recommended in the user manual.
Special precautions for disposal and other handling: Any unused product or waste material should be disposed of in accordance with local requirements.
Instructions for use and handling: To prevent the possible transmission of disease, each pen must be used by one patient only, even if the needle is changed.
The KwikPen should be rotated in the palms of the hands ten times and inverted 180° ten times immediately before use to resuspend the insulin until it appears uniformly cloudy or milky. If not, repeat the procedure until contents are mixed. Cartridges contain a small glass bead to assist mixing. Do not shake vigorously as this may cause frothing which may interfere with the correct measurement of dose.
The cartridges should be examined frequently and should not be used if clumps of material are present or if solid white particles stick to the bottom or wall of the cartridge, giving a frosted appearance.
Handling of the prefilled pen: Before using the KwikPen the user manual included in the package leaflet must be read carefully. The KwikPen has to be used as recommended in the user manual.
Storage
Unused prefilled pens: Store in a refrigerator (2°C-8°C). Do not freeze. Do not expose to excessive heat or direct sunlight.
After first use: Store below 30°C. Do not refrigerate. The prefilled pen should not be stored with the needle attached.
Shelf life: Unused prefilled pens: 3 years.
After first use: 28 days.
After first use: Store below 30°C. Do not refrigerate. The prefilled pen should not be stored with the needle attached.
Shelf life: Unused prefilled pens: 3 years.
After first use: 28 days.
Action
Pharmacotherapeutic Group: 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) is a premixed suspension consisting of insulin lispro (fast-acting human insulin analogue) and insulin lispro protamine suspension (intermediate acting human insulin analogue). ATC Code: A10A D04.
Pharmacology: Pharmacodynamics: The primary activity of insulin lispro is the regulation of glucose metabolism.
In addition, insulins have several anabolic and anti-catabolic actions on a variety of different tissues. Within muscle tissue this includes increasing glycogen, fatty acid, glycerol and protein synthesis and amino acid uptake, while decreasing glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism and amino acid output.
Insulin lispro has a rapid onset of action (approximately 15 minutes), thus allowing it to be given closer to a meal (within zero to 15 minutes of the meal) when compared to regular insulin (30 to 45 minutes before). The rapid onset and early peak of activity of insulin lispro is observed following the subcutaneous administration of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen). Insulin lispro protamine suspension has an activity profile that is very similar to that of a basal insulin over a period of approximately 15 hours.
In the figure as follows the pharmacodynamics of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) and insulin lispro protamine suspension are illustrated. (See figure.)
Pharmacology: Pharmacodynamics: The primary activity of insulin lispro is the regulation of glucose metabolism.
In addition, insulins have several anabolic and anti-catabolic actions on a variety of different tissues. Within muscle tissue this includes increasing glycogen, fatty acid, glycerol and protein synthesis and amino acid uptake, while decreasing glycogenolysis, gluconeogenesis, ketogenesis, lipolysis, protein catabolism and amino acid output.
Insulin lispro has a rapid onset of action (approximately 15 minutes), thus allowing it to be given closer to a meal (within zero to 15 minutes of the meal) when compared to regular insulin (30 to 45 minutes before). The rapid onset and early peak of activity of insulin lispro is observed following the subcutaneous administration of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen). Insulin lispro protamine suspension has an activity profile that is very similar to that of a basal insulin over a period of approximately 15 hours.
In the figure as follows the pharmacodynamics of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) and insulin lispro protamine suspension are illustrated. (See figure.)
The previous representation reflects the relative amount of glucose over time required to maintain the subject's whole blood glucose concentrations near fasting levels and is an indicator of the effects of these insulins on glucose metabolism over time.
The glucodynamic response to insulin lispro is not affected by renal or hepatic function impairment. Glucodynamic differences between insulin lispro and soluble human insulin, as measured during a glucose clamp procedure, were maintained over a wide range of renal function.
Insulin lispro has been shown to be equipotent to human insulin on a molar basis but its effect is more rapid and of a shorter duration.
Pharmacokinetics: The pharmacokinetics of insulin lispro reflect a compound that is rapidly absorbed, and achieves peak blood levels 30 to 70 minutes following subcutaneous injection. The pharmacokinetics of insulin lispro protamine suspension are consistent with those of an intermediate acting insulin such as NPH. The pharmacokinetics of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) are representative of the individual pharmacokinetic properties of the two components. When considering the clinical relevance of these kinetics, it is more appropriate to examine the glucose utilization curves (as discussed in Pharmacodynamics previously).
Insulin lispro maintains more rapid absorption when compared to soluble human insulin in patients with renal impairment. In patients with type 2 diabetes over a wide range of renal function the pharmacokinetic differences between insulin lispro and soluble human insulin were generally maintained and shown to be independent of renal function. Insulin lispro maintains more rapid absorption and elimination when compared to soluble human insulin in patients with hepatic impairment.
Toxicology: Preclinical safety data: In in vitro tests, including binding to insulin receptor sites and effects on growing cells, insulin lispro behaved in a manner that closely resembled human insulin. Studies also demonstrate that the dissociation of binding to the insulin receptor of insulin lispro is equivalent to human insulin. Acute, one month and twelve month toxicology studies produced no significant toxicity findings.
Insulin lispro did not induce fertility impairment, embryotoxicity or teratogenicity in animal studies.
The glucodynamic response to insulin lispro is not affected by renal or hepatic function impairment. Glucodynamic differences between insulin lispro and soluble human insulin, as measured during a glucose clamp procedure, were maintained over a wide range of renal function.
Insulin lispro has been shown to be equipotent to human insulin on a molar basis but its effect is more rapid and of a shorter duration.
Pharmacokinetics: The pharmacokinetics of insulin lispro reflect a compound that is rapidly absorbed, and achieves peak blood levels 30 to 70 minutes following subcutaneous injection. The pharmacokinetics of insulin lispro protamine suspension are consistent with those of an intermediate acting insulin such as NPH. The pharmacokinetics of 50% Insulin lispro and 50% Insulin lispro protamine (Humalog Mix50 KwikPen) are representative of the individual pharmacokinetic properties of the two components. When considering the clinical relevance of these kinetics, it is more appropriate to examine the glucose utilization curves (as discussed in Pharmacodynamics previously).
Insulin lispro maintains more rapid absorption when compared to soluble human insulin in patients with renal impairment. In patients with type 2 diabetes over a wide range of renal function the pharmacokinetic differences between insulin lispro and soluble human insulin were generally maintained and shown to be independent of renal function. Insulin lispro maintains more rapid absorption and elimination when compared to soluble human insulin in patients with hepatic impairment.
Toxicology: Preclinical safety data: In in vitro tests, including binding to insulin receptor sites and effects on growing cells, insulin lispro behaved in a manner that closely resembled human insulin. Studies also demonstrate that the dissociation of binding to the insulin receptor of insulin lispro is equivalent to human insulin. Acute, one month and twelve month toxicology studies produced no significant toxicity findings.
Insulin lispro did not induce fertility impairment, embryotoxicity or teratogenicity in animal studies.
MedsGo Class
Insulin Preparations
Features
Brand
Humalog Mix 50/50 Kwikpen
Full Details
Dosage Strength
100 units / ml (3.5 mg / ml)
Drug Ingredients
- Insulin Lispro
Drug Packaging
Suspension for Injection (S.C.) 3ml x 1's
Generic Name
Insulin Lispro
Dosage Form
Suspension for Injection (S.C.)
Registration Number
BR-990
Drug Classification
Prescription Drug (RX)
View all variations as list
| CODE | Dosage Strength | Drug Packaging | Availability | Price | ||
|---|---|---|---|---|---|---|
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RXDRUG-BR-990-1pc
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In stock
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₱47700 |