SEREDOL Haloperidol 5mg / mL Solution for IM Injection 1mL 1's

Treatment of various psychoses including schizophrenia, mania and in behaviour disturbances, severe anxiety and Tourette's syndrome.

 

Haloperidol is deeply injected by the intramuscular route.
The individual dose can be calculated from the oral daily dose of Haloperidol in mg. In mild and moderate psychotic conditions, a dose of respective 50-100 mg and 150-200 mg every 4 week is usually sufficient. In severe cases, a higher dose is often required (250-300 mg). For few patients needing more than 300 mg, the dosage can be increased.
Note: Neuroleptic cocktails can easily be replaced by an injection Haloperidol.
The dosage range can vary between 1 mg and over 200 mg per day depending on the condition and the individual response to treatment. Dosage should be titrated to clinical efficacy, then reduced to lowest effective level. Safety of prolonged administration of high dosages has not been demonstrated by controlled clinical trials. Children and debilitated or geriatric patients may be more sensitive to Haloperidol and require adjustment of the starting dose. The maximum dose and maintenance doses are generally lower for these patients.
Adults: Rapid emergency control: 1 mg. Up to 30 mg may given IM injection. Further doses may be repeated every six hours until control is achieved. At any time, oral dosage may be substituted in diminishing doses. The IV route may be used if required.
Children: Maintenance dosage: 0.05 mg/kg body weight/day. Where control is not urgent, treatment may be initiated at half the dosage level working up to maintenance dosage.

Neurologic disorders accompanied with pyramidical or extra-pyramidical symptoms.

Haloperidol may be given to epileptic but adequate anticonvulsant should be continued because the drug may lower the seizure threshold.
Acute dystonic reactions, including laryngeal spasm may be relieved promptly by the intravenous or intramuscular diazepam. A pseudo-parkinsonian rigidity syndrome may occur during the course of treatment which may also be treated with an antiparkinsonian drug.
Haloperidol does not usually affect blood pressure significantly but care should be exercised in patients with severe cardiovascular disorders because of the possibility of transient hypotension. Epinephrine should not be used since Haloperidol may block its vasopressor activity and cause a further decrease in blood pressure. As with other psychotic agents, Haloperidol has been associated with rare cases of neuroleptic malignant syndrome in which the patient experience fever, profound diaphoresis, autonomic dysfunction, muscular rigidity, altered consciousness and various level of coma. Recovery is usually complete within five to seven days of continuing Haloperidol.
Haloperidol should be administered cautiously to patients receiving anticoagulants since once instances of interference with the effects of phenindione have been reported. When haloperidol is used to control mania in cyclic disorders, a rapid mood swing to depression may occur.

As with other neuroleptics (adminisitered orally or parenterally) the start of the treatment may cause neurologic reactions of extrapyramidal nature such as muscular hypertonia and tremor (pseudoparkinsonism), a restless feeling in the lower limbs (akathisia), and even muscle cramps may be observed. These side effects can be neutralized by administering antiparkisonian or in cases of muscle cramps, by injecting a hypnosedative neuroleptic. When switching from an existing neuroleptic treatment to Haloperidol treatment, the antiparkinson medication can only reduced or stopped if the Haloperidol treatment has been stabilized.

 

Although Haloperidol has minimal soporific action, it should be recognized that the drug can potentiate the action of the central nervous system depressants, including alcohol.
High doses may potentiate the action of methyldopa as well.
As with tranquilizers, it should not be used alone where depression predominates but may be combined with antidepressants where there is associated anxiety.

Storage

Action

Antipsychotics