LAMITOR 50 Lamotrigine 50mg Tablet 1's
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Features
- Lamotrigine
Description
Indications/Uses
Dosage/Direction for Use
Add on therapy (without valproate): Adults: 50 mg once daily for 2 weeks followed by 50 mg twice daily for 2 weeks, thereafter the dose is increased by a maximum of 100 mg every 1 to 2 weeks to usual maintenance doses of 200 to 400 mg daily given in 2 divided doses. Some patients have required up to 700 mg daily.
Children 2 to 12 years: Initial dose is 600 mcg/kg body weight daily in 2 divided doses for 2 weeks followed by 1.2 mg/kg body weight in two divided doses for 2 weeks; thereafter the dose is increased by a maximum of 1.2 mg/kg body weight every 1 to 2 weeks to a usual maintenance dose of 5 to 15 mg/kg body weight given in 2 divided doses. Add on therapy (with valproate): Adults: Initial dose is 25 mg every other day for 2 weeks followed by 25 mg once daily for 2 weeks; thereafter the dose is increased by a maximum of 25 to 50 mg every 1 to 2 weeks to usual maintenance doses of 100 to 200 mg daily given as a single dose or in 2 divided doses.
Children: Initial dose is 150 mcg/kg body weight once daily for 2 weeks followed by 300 mcg/kg once daily for 2 weeks, thereafter the dose is increased by a maximum of 300 mcg/kg every 1 to 2 weeks to usual maintenance dose of 1 mg to 5 mg/kg body weight, which may be given once daily or in 2 divided doses. Or as prescribed by the physician.
Note: If the calculated dose for children lies between 1 and 2 mg then 2 mg may be given on alternate days for the first 2 weeks of therapy. Lamotrigine should not be administered if the calculated dose is less than 1 mg.
For Bipolar Disorder: As Monotherapy: The initial recommended dosage is 25 mg once daily which is gradually increased to 200 mg daily over 6 weeks. Dosages over 200 mg/day as monotherapy are not recommended.
For patients taking valproate: 25 mg every other day and the target dosage is 100 mg/day from week 6.
In recipients of carbamazepine (or other enzyme inducing drugs): the initial recommended dosage is 50 mg once daily which is gradually increased up to 400 mg/day from week 7. Dosages >50 mg/day can be given once daily or as two divided doses.
Administration
Contraindications
Special Precautions
Withdrawal: Withdrawal of Lamotrigine should be considered if rash, fever, flu-like symptoms, drowsiness, or worsening of seizure control occurs.
Care is required when withdrawing lamotrigine therapy. Abrupt withdrawal should be avoided unless serious skin reactions have occurred.
Adverse Reactions
Other adverse effects include angioedema and photosensitivity, diplopia, blurred vision, and conjunctivitis, and dizziness, drowsiness, insomnia, headache, ataxia, nystagmus, tremor, tiredness, nausea and vomiting, irritability and aggression, hallucinations, agitation and confusion.
Drug Interactions
Some estrogen-containing oral contraceptives have been shown to decrease serum concentrations of lamotrigine.