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Indications/Uses
Fluphenazine is used in the treatment of psychiatric disorders including schizophrenia, mania, severe anxiety and behavioural disturbances.
Dosage/Direction for Use
Fluphenazine decanoate are usually given by deep intramuscular injection and are used mainly for the maintenance treatment of patients with schizophrenia or other chronic psychoses. The onset of action is usually within 1 to 3 days of injection and significant effects on psychosis are usually evident within 2 to 4 days.
An initial dose of fluphenazine decanoate 12.5 mg (6.25 mg in the elderly) is given intramuscularly. Subsequent adjustments in the amounts and the dosage interval should be made according to the patient’s response; the amounts required may range from 12.5 to 100 mg and the intervals required may range from 2 weeks to 5 or 6 weeks. Lower doses may be possible in some patients. If doses greater than 50 mg are considered necessary, cautious increments should be made in steps of 12.5 mg.
An initial dose of fluphenazine decanoate 12.5 mg (6.25 mg in the elderly) is given intramuscularly. Subsequent adjustments in the amounts and the dosage interval should be made according to the patient’s response; the amounts required may range from 12.5 to 100 mg and the intervals required may range from 2 weeks to 5 or 6 weeks. Lower doses may be possible in some patients. If doses greater than 50 mg are considered necessary, cautious increments should be made in steps of 12.5 mg.
Contraindications
May exacerbate depression & therefore is contraindicated in severely depressed patients. Hypersensitivity to fluphenazine. Severely depressed patients. Childn <12 yr.
Special Precautions
Fluphenazine may exacerbate depression and therefore it is contra-indicated in severly depressed patients. It is not intended for use in pediatric patients under 12 years of age and in patients who have shown hypersensitivily to fluphenazine; cross-sensitivity to phenothiazine derivatives may occur.
Adverse Reactions
Fluphenazine is less likely to cause sedation, hypotension or antimuscarinic effects but is associated with a higher incidene of extrapyramidal effects.
Storage
Store at temperatures not exceeding 30ºC.
Protect from light. Do not freeze.
Protect from light. Do not freeze.
Action
Pharmacology: Pharmacokinetics: Fluphanezine decanoate is very slowly absorbed from the site of subcutaneous or intramuscular injection. It gradually release fluphenazine into the body and are therefore suitable for use as depot injections. The plasma half-life of fluphenazine decanoate has been reported to be 6 to 9 days after intramuscular injection.
MedsGo Class
Antipsychotics
Features
Brand
Flenazine
Full Details
Dosage Strength
25 mg / mL
Drug Ingredients
- Fluphenazine
Drug Packaging
Solution for Injection 1ml x 1's
Generic Name
Fluphenazine Decanoate
Dosage Form
Solution for Injection
Registration Number
DR-XY44876
Drug Classification
Prescription Drug (RX)