CYLINE Citicoline Sodium 1g Film-Coated Tablet 1's
RXDRUG-DR-XY39579-1pc
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
It is used in the treatment of cerebrovascular disorders including ischemic stroke, parkinsonism and head injuries.
Dosage/Direction for Use
Take one 1 g FCT by mouth once a day or as prescribed by the physician.
Administration
May be taken with or without food.
Contraindications
Patients with hypertonia of the parasympathetic nervous system.
Special Precautions
Citicoline should be used with caution in patients with acute, severe, and progressive disturbances, intracranial pressure relieving drugs or use measures to keep body temperature low.
Use in Children: It has not been established whether citicoline may adversely affect children.
Use in the Elderly: Use in elderly should be taken with caution considering manifestation of adverse effects.
Use in Children: It has not been established whether citicoline may adversely affect children.
Use in the Elderly: Use in elderly should be taken with caution considering manifestation of adverse effects.
Adverse Reactions
Increased parasympathetic effects, fleeting and discrete hypotensor effect.
Drug Interactions
Citicoline potentiates the effects of L-dopa. It must not be administered with meclofenoxate (clophenoxate).
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Citicoline is a derivative of choline and cytidine that is involved in the biosynthesis of lecithin. It is claimed to increase blood flow and oxygen consumption in the brain and has been given in the treatment of cerebrovascular disorders, Parkinsonism, and head injury.
Citicoline is an interneuronal communication enhancer. It increases the neurotransmission levels because it favors the synthesis and production speed of dopamine in the striatum, acting then as a dopaminergic agonist thru the inhibition of tyrosine hydroxylase. Citicoline acts as a presynaptic cholinergic agent which favors the synthesis of acetylcholine. It also decreases the release of serotonin. Citicoline makes the neurons more active, causing the astrocytes to loosen their grip on the capillaries, thus improving microcirculation. By virtue of this action, citicoline has an indirect effect on microcirculation. It has the ability to slightly increase cerebral blood flow and exerts an anti-aggregation effect on platelets.
Pharmacokinetics: When administered orally, it is absorbed almost completely, and its bioavailability is approximately the same when administered intravenously.
Once absorbed, the cytidine and choline disperse widely throughout the body, cross the blood brain barrier, and reach the central nervous system (CNS), where they are incorporated into the phospholipid fraction of the cellular membrane and microsomes.
The concept that administration of exogenous Citicoline can augment the synthesis of neural membrane phospholipid is attractive, because accelerated replacement or repair plays a critical role in maintaining the healthy function of numerous physiological processes. It has shown therapeutic efficacy in a variety of diseases in which membrane disorder, dysfunction, or degeneration result in cellular and tissue ischaemia and necrosis.
Citicoline is an interneuronal communication enhancer. It increases the neurotransmission levels because it favors the synthesis and production speed of dopamine in the striatum, acting then as a dopaminergic agonist thru the inhibition of tyrosine hydroxylase. Citicoline acts as a presynaptic cholinergic agent which favors the synthesis of acetylcholine. It also decreases the release of serotonin. Citicoline makes the neurons more active, causing the astrocytes to loosen their grip on the capillaries, thus improving microcirculation. By virtue of this action, citicoline has an indirect effect on microcirculation. It has the ability to slightly increase cerebral blood flow and exerts an anti-aggregation effect on platelets.
Pharmacokinetics: When administered orally, it is absorbed almost completely, and its bioavailability is approximately the same when administered intravenously.
Once absorbed, the cytidine and choline disperse widely throughout the body, cross the blood brain barrier, and reach the central nervous system (CNS), where they are incorporated into the phospholipid fraction of the cellular membrane and microsomes.
The concept that administration of exogenous Citicoline can augment the synthesis of neural membrane phospholipid is attractive, because accelerated replacement or repair plays a critical role in maintaining the healthy function of numerous physiological processes. It has shown therapeutic efficacy in a variety of diseases in which membrane disorder, dysfunction, or degeneration result in cellular and tissue ischaemia and necrosis.
MedsGo Class
Nootropics & Neurotonics/Neurotrophics / Peripheral Vasodilators & Cerebral Activators
Features
Brand
Cyline
Full Details
Dosage Strength
1 g
Drug Ingredients
- Citicoline
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Citicoline Sodium
Dosage Form
Film-Coated Tablet
Registration Number
DR-XY39579
Drug Classification
Prescription Drug (RX)
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