VASCOR Imidapril Hydrochloride 10mg Tablet 1's
Indications/Uses
Dosage/Direction for Use
Administration
Contraindications
Warnings
Special Precautions
Imidapril should be used with caution in patients with unilateral or bilateral renal artery stenosis since increase in blood urea nitrogen and serum creatinine may occur.
In general, ACE inhibitors should be used with caution in patients with sodium depletion or hypovolemia and those undergoing dialysis, major surgery or during anesthesia since severe hypotension may occur.
Use in lactation: Imidapril is excreted in breast milk therefore, avoid use of the drug in nursing mothers.
Use In Pregnancy & Lactation
Use in lactation: Imidapril is excreted in breast milk therefore, avoid use of the drug in nursing mothers.
Adverse Reactions
Abnormal laboratory test values were observed in 5.6% (47/832) of patients but none is considered related to imidapril treatment.
Drug Interactions
Lithium toxicity has been reported in patients receiving lithium concomitantly with ACE inhibitors.
Storage
Action
Pharmacology: Imidapril is an ester prodrug which is hydrolyzed after absorption to imidaprilat, the active metabolite. Imidaprilat has potent angiotensin-converting enzyme (ACE) inhibitory effects, 1.2 and 2.6 times that of enalaprilat and captopril, respectively.
The hypotensive effect of imidapril is mainly due to ACE inhibition and the consequent reduction in angiotensin II, resulting in dilatation of peripheral vessels and reduction in vascular resistance. The hypotensive effect of imidapril is comparable to enalapril and 5-10 times more potent than that of captopril.
Imidapril decreases total peripheral vascular resistance without increase in heart rate or cardiac contractility. Imidapril increases renal blood flow and reduces renal vascular resistance mainly due to dilatation of the efferent arteriole. It showed no specific effect on the CNS, digestive, respiratory, smooth muscle, reproductive, urologic, hematologic and metabolic systems.
Pharmacokinetics: About 25-40% of imidapril is absorbed after oral administration. Imidapril undergoes deesterification in the liver to form imidaprilat. Peak plasma concentrations of imidaprilat are reached within 6-8 hrs after single oral doses of 2.5-20 mg of imidapril, and decline slowly with a t½ of 7-9 hrs. Imidapril and imidaprilat were shown to be about 85% and 51% protein bound, respectively.
Drug elimination is primarily via the renal (40%) and hepatobiliary (50%) routes. Increased age and impaired renal function may decrease the urinary excretion of imidapril and its metabolites.
MedsGo Class
Features
- Imidapril