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Indications/Uses
It is used in the management of peripheral vascular disease; often used for atherosclerotic or occlusive arterial disease but in its widest sense covers both arterial and venous disorders and may be due to atherosclerosis, vasospasm, or thromboembolism.
Dosage/Direction for Use
The usual dose is 100 mg twice daily, at least 30 minutes before meal or 2 hours after meal; doses should be reduced in patients taking enzyme inhibitors. Response to treatment may occur in 2 to 4 weeks, but up to 12 weeks may be required. Or as prescribed by the physician.
Administration
Should be taken on an empty stomach: Take at least 30 min before or 2 hr after meals.
Contraindications
Cilostazol is contraindicated in patients with congestive heart failure of any severity. It is also contraindicated in patients with a known predisposition to bleeding, a history of ventricular arrhythmias, QT interval prolongation, severe renal impairment, or moderate to severe hepatic impairment.
Cilostazol Tablet is contraindicated in patients with known or suspected hypersensitivity to any of its components.
Cilostazol Tablet is contraindicated in patients with known or suspected hypersensitivity to any of its components.
Special Precautions
Cilostazol should be avoided or used in reduced doses in patients taking inhibitors of the cytochrome P450 isoenzymes CYP3A4 or CYP2C19.
Adverse Reactions
Adverse effects of Cilostazol include headache, dizziness, palpitations, and diarrhoea; oedema, nausea and vomiting, other cardiac arrhythmias, chest pain, rhinitis, ecchymosis, and skin rashes have also been reported. Cardiovascular toxicity has been reported in animal studies of Cilostazol, and prolonged oral use of other phosphodiesterase inhibitors for the treatment of heart failure has been associated with increased mortality.
Drug Interactions
Cilostazol is extensively metabolised to active and inactive metabolites by cytochrome P450 isoenzymes, mainly CYP3A4 and to a lesser extent CYP2C19. Therefore use with other drugs that inhibit or are metabolised by these hepatic enzymes may result in changes in plasma concentrations of either drug and, possibly, adverse effects. Cilostazol should therefore be used with caution in patients taking drugs metabolised by these enzymes; in patients taking enzyme inhibitors it should be avoided or a reduced dose of 50 mg twice daily should be considered.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacokinetics: Cilostazol is absorbed after oral doses and absorption is increased if taken with a high fat meal. Cilostazol is extensively metabolised in the liver by cytochrome P450 isoenzymes, mainly CYP3A4 and to a lesser extent CYP2C19, to both active and inactive metabolites; these are predominantly excreted in the urine (74%) with the remainder in the faeces (20%). The active metabolites have apparent elimination half-lives of 11 to 13 hours. Cilostazol is 95 to 98% protein bound.
MedsGo Class
Anticoagulants, Antiplatelets & Fibrinolytics (Thrombolytics)
Features
Brand
Pletaxol
Full Details
Dosage Strength
50 mg
Drug Ingredients
- Cilostazol
Drug Packaging
Tablet 30's
Generic Name
Cilostazol
Dosage Form
Tablet
Registration Number
DRP-7494
Drug Classification
Prescription Drug (RX)