HYPACE Enalapril Maleate 5mg - 1 Tablet

Indications / Uses

HYPACE Enalapril 5mg is used for the management of high blood pressure, which is also known as hypertension. It is also utilized for the treatment of symptomatic heart failure, typically in combination with other necessary therapies. Furthermore, this product is indicated for the prevention of symptomatic heart failure in patients who have asymptomatic left ventricular dysfunction.

Formulation / Ingredients

HYPACE Enalapril 5mg contains: Enalapril Maleate 5mg + Inactive ingredients including corn starch, lactose monohydrate, magnesium stearate, pregelatinized starch, and sodium bicarbonate.

Side Effects

HYPACE Enalapril 5mg common side effects include: dizziness, headache, and a dry, persistent cough. Other potential effects that can be experienced are fatigue, nausea, and diarrhea. More serious, though less frequent, adverse effects to watch out for include swelling of the face, lips, tongue, or throat (angioedema), which requires immediate attention, and sometimes a rash or orthostatic effects (feeling lightheaded when standing up). Changes in laboratory values such as an increase in serum potassium or creatinine can also occur.

Directions and Dosage

• Dosage for Adults (18+ years) for Hypertension: The initial dose is typically 5 to 20 mg once daily. The usual maintenance dose is 20 mg daily. The maximum daily dose is 40 mg.
• Dosage for Adults (18+ years) for Symptomatic Heart Failure: The initial dose is usually 2.5 mg once or twice daily. The dose is gradually increased as tolerated, with the usual maintenance dose being 20 mg daily, given in one or two doses. The maximum daily dose is 40 mg, split into two doses of 20 mg.
• Dosage for Kids for Hypertension (20 to <50 kg): The recommended initial dose is 2.5 mg once daily. The maximum daily dose is 20 mg.
• Dosage for Kids for Hypertension ($\geq$50 kg): The recommended initial dose is 5 mg once daily. The maximum daily dose is 40 mg.

Not recommended for children under 1 month of age. For those with kidney problems, dosage adjustments are required.

Contraindications

It should not be used in individuals with a known hypersensitivity or allergy to the product or any other angiotensin-converting enzyme (ACE) inhibitor. Use is also restricted in patients who have a history of angioedema (severe swelling) related to previous ACE inhibitor treatment, or in those with hereditary or idiopathic angioedema. It should not be used concurrently with aliskiren in patients who have diabetes or moderate to severe kidney impairment. Also, do not take within 36 hours of switching to or from a medication containing a neprilysin inhibitor (e.g., sacubitril/valsartan combination).

Use in Pregnancy and Lactation

The use of this product during the second and third trimesters of pregnancy can cause injury and death to the developing fetus and must be discontinued immediately if pregnancy is detected. It is not recommended for use while breastfeeding.

Special Precautions

• Use with caution in individuals who have left ventricular valvular or outflow tract obstruction, such as aortic stenosis or hypertrophic cardiomyopathy.
• Patients with impaired kidney function or those with severe heart failure may experience changes in kidney function, especially when therapy is initiated.
• Patients who are volume-depleted, such as those on high-dose diuretics or with dietary salt restriction, may be at higher risk for low blood pressure.
• Monitoring of kidney function and serum potassium levels is important during treatment.

Is it safe to take it with other medications?

Concomitant use with potassium supplements, potassium-sparing salts, or other drugs that increase potassium levels should be avoided or closely monitored, as this can lead to high potassium levels in the blood. Non-steroidal anti-inflammatory drugs (NSAIDs) may reduce the blood pressure-lowering effect and can potentially worsen kidney function. Combining with certain other blood pressure medications may increase the risk of side effects like low blood pressure.

How should I store it?

Store the product at room temperature, ideally between 20°C to 25°C. Keep it in a dry place, protected from moisture and direct heat.

Used For

Hypertension, Heart Failure

Age

1 month & up