HARTZAR Losartan Potassium 50mg Tablet 50's
RXDRUG-DRP-128-05
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Losartan Potassium is used in the management of hypertension and may have a role in patients who develop cough with ACE inhibitors.
Dosage/Direction for Use
Usual Dose: 50 mg once daily.
The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses. An initial dose of 25 mg once daily may be used in the elderly over 75 years, and for patients with moderate to severe renal impairment. (Creatinine clearance less than 20 mL per minute), or intravascular fluid depletion.
Or as prescribed by the physician.
The dose may be increased, if necessary, to 100 mg daily as a single dose or in two divided doses. An initial dose of 25 mg once daily may be used in the elderly over 75 years, and for patients with moderate to severe renal impairment. (Creatinine clearance less than 20 mL per minute), or intravascular fluid depletion.
Or as prescribed by the physician.
Administration
May be taken with or without food.
Contraindications
Pregnancy.
Special Precautions
Losartan Potassium should be used with care, if at all, during breastfeeding. It should be used with caution in patients with renal artery stenosis. Reduced doses may be required in patients with renal or hepatic impairment. Patients with volume depletion may experience hypotension.
Adverse Reactions
Adverse effects include dizziness and dose-related orthostatic hypotension. Hypotension may occur particularly in patients with volume depletion (for example those who have received high-dose diuretics). Losartan Potassium may cause hyperkalemia in patients with renal disease. Other adverse effects that have been reported with angiotensin II receptor antagonist include respiratory tract disorder, back pain, gastrointestinal disturbances, fatigue, and neutropenia.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacokinetics: Losartan Potassium is an angiotensin II receptor antagonist with antihypertensive activity due mainly to selective blockade of ATP's receptors and the consequent reduced pressure effect of angiotensin II.
Losartan Potassium is readily absorbed from the gastrointestinal tract following oral administration, with an oral bioavailability of about 33%. It undergoes first pass metabolism to form an active carboxylic acid metabolites E-3174 (EXP-3174), which has greater pharmacological activity than losartan, and some inactive metabolites. Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and E-3174 occur about 1 hour and 3 to 4 hours, respectively, after an oral dose. Both losartan and E-3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine and in the feces via bile, as unchanged drug and metabolites. Following oral dosing, about 35% of the dose is excreted in the urine and about 60% in the feces. The terminal elimination half-lives of losartan and E-3174 are about 1.5 hours to 2.5 hours and 3 to 9 hours respectively.
Losartan Potassium is readily absorbed from the gastrointestinal tract following oral administration, with an oral bioavailability of about 33%. It undergoes first pass metabolism to form an active carboxylic acid metabolites E-3174 (EXP-3174), which has greater pharmacological activity than losartan, and some inactive metabolites. Metabolism is primarily by cytochrome P450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and E-3174 occur about 1 hour and 3 to 4 hours, respectively, after an oral dose. Both losartan and E-3174 are more than 98% bound to plasma proteins. Losartan is excreted in the urine and in the feces via bile, as unchanged drug and metabolites. Following oral dosing, about 35% of the dose is excreted in the urine and about 60% in the feces. The terminal elimination half-lives of losartan and E-3174 are about 1.5 hours to 2.5 hours and 3 to 9 hours respectively.
MedsGo Class
Angiotensin II Antagonists
Features
Brand
Hartzar
Full Details
Dosage Strength
50 mg
Drug Ingredients
- Losartan
Drug Packaging
Tablet 50's
Generic Name
Losartan Potassium
Dosage Form
Tablet
Registration Number
DRP-128-05
Drug Classification
Prescription Drug (RX)
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