GETZAR Losartan Potassium 100mg Film-Coated Tablet 1's
RXDRUG-DRP-1667-02-1pc
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Management of HTN & may have a role in patients who develop cough w/ ACE inhibitors.
Dosage/Direction for Use
Usual Dose: 50 mg once daily.
The dose may be increased, if necessary, to 100 mg daily as a single dose or in 2 divided doses.
Elderly (>75 years) and Patients with Moderate to Severe Renal Impairment (Creatinine Clearance <20 mL/min): Initial Dose: 25 mg daily.
Intravascular Fluid Depletion: Initial Dose: 25 mg daily.
The dose may be increased, if necessary, to 100 mg daily as a single dose or in 2 divided doses.
Elderly (>75 years) and Patients with Moderate to Severe Renal Impairment (Creatinine Clearance <20 mL/min): Initial Dose: 25 mg daily.
Intravascular Fluid Depletion: Initial Dose: 25 mg daily.
Administration
May be taken with or without food.
Contraindications
Pregnancy.
Special Precautions
Getzar should be used with care, if at all, during breastfeeding. It should be used with caution in patients with renal artery stenosis. Reduced doses may be required in patients with renal or hepatic impairment. Patients with volume depletion may experience hypotension.
Use In Pregnancy & Lactation
Use in Pregnancy: Getzar is contraindicated in pregnancy.
Use in Lactation: Getzar should be used with care, if at all, during breastfeeding
Use in Lactation: Getzar should be used with care, if at all, during breastfeeding
Adverse Reactions
Adverse effects include dizziness and dose-related orthostatic hypotension. Hypotension may occur particularly in patients with volume depletion (eg, those who have received high-dose diuretics). Getzar may cause hyperkalemia in patients with renal disease. Other adverse effects that have been reported with angiotensin II receptor antagonist include respiratory tract disorder, back pain, GI disturbances, fatigue and neutropenia.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacokinetics: Losartan potassium is an angiotensin II receptor antagonist with antihypertensive activity due mainly to selective blockade of AT1 receptors and the consequent reduced effect of angiotensin II.
Losartan potassium is readily absorbed from the GIT following oral administration, with an oral bioavailability of about 33%. It undergoes first-pass metabolism to form an active carboxylic acid metabolite E-3174 (EXP-3174), which has greater pharmacological activity than losartan and some inactive metabolites. Metabolism is primarily by cytochrome P-450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and E-3174 occur about 1 hr and 3-4 hrs, respectively, after an oral dose. Both losartan and E-3174 are >98% bound to plasma proteins. Losartan is excreted in the urine and in the feces via bile, as unchanged drug and metabolites. Following oral dosing, about 35% of the dose is excreted in the urine and about 60% in the feces. The terminal elimination t½ of losartan and E-3174 are about 1.5-2.5 hrs and 3-9 hrs, respectively.
Losartan potassium is readily absorbed from the GIT following oral administration, with an oral bioavailability of about 33%. It undergoes first-pass metabolism to form an active carboxylic acid metabolite E-3174 (EXP-3174), which has greater pharmacological activity than losartan and some inactive metabolites. Metabolism is primarily by cytochrome P-450 isoenzymes CYP2C9 and CYP3A4. Peak plasma concentrations of losartan and E-3174 occur about 1 hr and 3-4 hrs, respectively, after an oral dose. Both losartan and E-3174 are >98% bound to plasma proteins. Losartan is excreted in the urine and in the feces via bile, as unchanged drug and metabolites. Following oral dosing, about 35% of the dose is excreted in the urine and about 60% in the feces. The terminal elimination t½ of losartan and E-3174 are about 1.5-2.5 hrs and 3-9 hrs, respectively.
MedsGo Class
Angiotensin II Antagonists
Features
Brand
Getzar
Full Details
Dosage Strength
100 mg
Drug Ingredients
- Losartan Potassium
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Losartan Potassium
Dosage Form
Film-Coated Tablet
Registration Number
DRP-1667-02
Drug Classification
Prescription Drug (RX)
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