ENTRESTO Sacubitril - Valsartan 100mg - 1 Tablet

Indications / Uses

ENTRESTO Sacubitril - Valsartan 100mg is used for the treatment of symptomatic chronic heart failure in adult patients with reduced ejection fraction to reduce the risk of cardiovascular death and hospitalization. It is also indicated for the treatment of symptomatic heart failure in pediatric patients aged 1 year and older. This combination therapy works by enhancing the protective neurohormonal systems of the heart while simultaneously inhibiting the harmful effects of the overactive renin-angiotensin-aldosterone system.

Formulation / Ingredients

ENTRESTO Sacubitril - Valsartan 100mg contains: Sacubitril 48.6mg + Valsartan 51.4mg

Side Effects

ENTRESTO Sacubitril - Valsartan 100mg common side effects include: low blood pressure (hypotension), increased potassium levels in the blood (hyperkalemia), and impaired kidney function (renal impairment). Some patients may also experience cough, dizziness, or localized swelling of deeper skin layers known as angioedema. Fatigue and fainting can occur if blood pressure drops too significantly during the start of therapy.

Directions and Dosage

• Adults (18+ years): 1 tablet twice daily. Dosage may be increased to 200mg twice daily depending on tolerability.
• Kids 1 year and older (weighing 40kg to less than 50kg): 1 tablet twice daily.
• Kids 1 year and older (weighing less than 40kg): Dosage is based on weight using the oral suspension or lower strength tablets.

Not recommended for children under 1 year. Maximum daily dosage: 400mg (expressed as two 200mg doses). Long-term treatment is required for chronic conditions.

Contraindications

Hypersensitivity to the active ingredients. History of angioedema associated with previous ACE inhibitor or ARB therapy. Hereditary or idiopathic angioedema. Concurrent use with ACE inhibitors or aliskiren-containing medicines in patients with diabetes. Severe hepatic impairment or biliary cirrhosis.

Use in Pregnancy and Lactation

Strictly contraindicated during the second and third trimesters of pregnancy due to risks of fetal toxicity and death. Use during the first trimester is not recommended. Breastfeeding should be discontinued during treatment as risks to the newborn cannot be excluded.

Special Precautions

• Regular monitoring of serum potassium and renal function is required throughout the treatment duration.
• Caution is necessary in patients with severe renal impairment or renal artery stenosis.
• Treatment should not be initiated until at least 36 hours after the last dose of an ACE inhibitor.

Is it safe to take it with other medications?

Do not combine with ACE inhibitors. Increased risk of drug interactions with potassium-sparing diuretics, lithium, and non-steroidal anti-inflammatory drugs (NSAIDs) which may lead to kidney failure or high potassium levels.

How should I store it?

Store at temperatures not exceeding 30°C. Protect from moisture by keeping the tablets in the original blister package until the time of use.

Used For

Heart failure

Age

1 year & up