EDEMANN Furosemide 40mg Tablet 1's
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Features
- Furosemide
Description
Indications/Uses
Hypertension: Alone or in combination with other antihypertensive agents in adults. Hypertensive patients who cannot be adequately controlled with thiazides will probably also not be adequately controlled with furosemide alone.
Dosage/Direction for Use
Administration
Contraindications
Warnings
In patients with hepatic cirrhosis and ascites, furosemide therapy is best initiated in the hospital. In hepatic coma and in states of electrolyte depletion, therapy should not be instituted until the basic condition is improved. Sudden alterations of fluid and electrolyte balance in patients with cirrhosis may precipitate hepatic coma; therefore, strict observation is necessary during the period of diuresis.
Supplemental potassium chloride and, if required, aldosterone antagonists are helpful in preventing hypokalemia and metabolic alkalosis if increasing azotemia and oliguria occur during treatment of severe progressive renal disease.
Furosemide should be discontinued in cases of tinnitus since reversible and irreversible hearing impairment have been reported. Usually, reports indicate that diuretic treatment with furosemide in the 1st few weeks in premature neonates with respiratory distress syndrome may increase the risk of persistent patent ductus arteriosus (PDA), possibly through a prostaglandin E-mediated process.
Special Precautions
Drug Interactions
Furosemide may increase the ototoxic potential of aminoglycoside antibiotics.
Furosemide should not be used concomitantly with ethacrynic acid because of the possibility of ototoxicity. Patients receiving high doses of salicylates concomitantly with furosemide, as in rheumatic disease, may experience salicylate toxicity at lower doses because of competitive renal excretory sites.
Furosemide has a tendency to antagonize the skeletal muscle-relaxing effect of tubocurarine and may potentiate the action of succinylcholine. Lithium generally should not be given with diuretics because they reduce lithium's renal clearance and add a high risk of lithium toxicity.
Furosemide may decrease arterial responsiveness to norepinephrine.