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Indications/Uses
Indicated in patients requiring diuresis and concomitant potassium supplementation. Indication includes cardiac edema, pulmonary edema, hepatic edema, renal edema and peripheral edema of various etiologies.
Dosage/Direction for Use
One tablet daily by mouth, usually in the morning. Dose may be adjusted according to the patient's response.
Note: Diumide-K tablet should not be chewed so as not to destroy the controlled release system constituting the potassium chloride layer.
Or as prescribed by the physician.
Note: Diumide-K tablet should not be chewed so as not to destroy the controlled release system constituting the potassium chloride layer.
Or as prescribed by the physician.
Overdosage
Treatment of overdose should be aimed at fluid replacement and correction of the resulting electrolyte imbalance.
Administration
Should be taken with food: Swallow whole, do not chew/crush.
Contraindications
Diumide-K tablets are contraindicated in hyperkalaemia, pre-comatose states associated with hepatic cirrhosis. It should be used with care in patients with prostatic hyperplasia or impairment of micturition since it can precipitate acute urinary retention.
Should be used with caution during pregnancy and breast feeding since furosemide crosses the placenta and also appears in breastmilk. Furosemide may compromise placental perfusion by reducing maternal blood volume; it may also inhibit lactation.
Should be used with caution during pregnancy and breast feeding since furosemide crosses the placenta and also appears in breastmilk. Furosemide may compromise placental perfusion by reducing maternal blood volume; it may also inhibit lactation.
Special Precautions
Care should be taken in patients being concurrently administered with cardiac glycosides, hypotensive agents and cephaloridine. Care should be exercised in patients with renal insufficiency where there is a risk of hyperkalaemia.
Diumide-K tablet should be administered with caution during the first trimester of pregnancy. As with all medicines, Diumide-K tablet should be kept out of reach of children.
Diumide-K tablet should be administered with caution during the first trimester of pregnancy. As with all medicines, Diumide-K tablet should be kept out of reach of children.
Use In Pregnancy & Lactation
Should be used with caution during pregnancy and breast feeding since furosemide crosses the placenta and also appears in breastmilk. Furosemide may compromise placental perfusion by reducing maternal blood volume; it may also inhibit lactation.
Diumide-K tablet should be administered with caution during the first trimester of pregnancy.
Diumide-K tablet should be administered with caution during the first trimester of pregnancy.
Adverse Reactions
Allergic reaction; hyperuricemia; bone marrow depression.
Drug Interactions
Diumide-K may enhance the nephrotoxicity of cephalosporin antibacterial such as cefalotin and can enhance the ototoxicity of aminoglycoside antibacterial and other ototoxic drugs.
Caution For Usage
Further Information: Furosemide produces a rapid and sustained diuresis which lasts for approximately four hours following administration.
The potassium chloride content is release from the tablet over a prolonged period, ensuring maximum absorption and maximize "flushing out" of the potassium by the action of the diuretic as well as gastric side effects.
The potassium chloride content is release from the tablet over a prolonged period, ensuring maximum absorption and maximize "flushing out" of the potassium by the action of the diuretic as well as gastric side effects.
Storage
Store at temperatures not exceeding 30°C.
Shelf-Life: 24 months.
Shelf-Life: 24 months.
Action
Pharmacology: Pharmacokinetics: Furosemide is fairly rapidly absorbed from the gastrointestinal tract; bioavailability has been reported to be about 60 to 70% but absorption is variable and erratic. The half-life is up to about 2 hours, it is prolonged in neonates and in patients with renal and hepatic impairment. It is up to 99% bound to plasma albumin, and is mainly excreted in the urine, largely unchanged. Furosemide crosses the placenta barrier and is distributed into breastmilk. The clearance of Furosemide is not increased by hemodialysis.
Potassium salts are generally readily absorbed from the gastrointestinal tract. Potassium is excreted mainly from the kidneys; it is secreted in their distal tubules in exchange for sodium or hydrogen ions. Some potassium is excreted in the feces and small amounts may also be excreted in sweat.
Potassium salts are generally readily absorbed from the gastrointestinal tract. Potassium is excreted mainly from the kidneys; it is secreted in their distal tubules in exchange for sodium or hydrogen ions. Some potassium is excreted in the feces and small amounts may also be excreted in sweat.
MedsGo Class
Diuretics
Features
Brand
Diumide-K
Full Details
Dosage Strength
40 mg / 600 mg
Drug Ingredients
- Furosemide
- Potassium Chloride
Drug Packaging
Film-Coated Tablet 50's
Generic Name
Furosemide / Potassium Chloride
Dosage Form
Film-Coated Tablet
Registration Number
DR-XY2615
Drug Classification
Prescription Drug (RX)