Please sign in so that we can notify you about a reply
Indications/Uses
Treatment of the symptoms and signs of organic and idiopathic chronic venous disease of the lower limbs eg, heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
Treatment of the symptoms of acute hemorrhoidal attacks and chronic hemorrhoidal disease.
Treatment of the symptoms of acute hemorrhoidal attacks and chronic hemorrhoidal disease.
Dosage/Direction for Use
Usual Dose: Chronic Venous Disease: 2 tablets daily with meals.
Chronic Hemorrhoidal Disease: 2 tablets daily with meals.
Acute Hemorrhoidal Attack: 6 tablets daily (in 2 divided doses) for 4 days, then 4 tablets daily (in 2 divided doses) for 3 days, 2 tablets thereafter.
Should be taken with food: Take at mealtimes.
Or as prescribed by the physician.
Chronic Hemorrhoidal Disease: 2 tablets daily with meals.
Acute Hemorrhoidal Attack: 6 tablets daily (in 2 divided doses) for 4 days, then 4 tablets daily (in 2 divided doses) for 3 days, 2 tablets thereafter.
Should be taken with food: Take at mealtimes.
Or as prescribed by the physician.
Administration
Should be taken with food.
Contraindications
Hypersensitivity to the active substance or to any of the excipients of Diosmin + Hesperidin.
Special Precautions
The administration of Diosmin + Hesperidin for the symptomatic treatment of acute hemorrhoids does not preclude treatment for other anal conditions. If symptoms do not subside promptly, a proctological examination should be performed and the treatment should be reviewed.
Use in pregnancy & lactation: Experimental studies have not shown any teratogenic effect in animals. In human beings, no harmful effect has so far been reported.
In the absence of data concerning the diffusion into breast milk, breastfeeding is not recommended during treatment.
Use in pregnancy & lactation: Experimental studies have not shown any teratogenic effect in animals. In human beings, no harmful effect has so far been reported.
In the absence of data concerning the diffusion into breast milk, breastfeeding is not recommended during treatment.
Use In Pregnancy & Lactation
Experimental studies have not shown any teratogenic effect in animals. In human beings, no harmful effect has so far been reported.
In the absence of data concerning the diffusion into breast milk, breastfeeding is not recommended during treatment.
In the absence of data concerning the diffusion into breast milk, breastfeeding is not recommended during treatment.
Adverse Reactions
Like all medicines, Diosmin + Hesperidin can cause side effects, although not everybody gets them. Diosmin + Hesperidin is usually well tolerated. The following side effects can appear: Common (<1/10, >10/100): Diarrhea, dyspepsia, nausea, vomiting.
Uncommon (<1/100, >1000): Colitis.
Rare (<1/1000, >1/10,000): Dizziness, headache, malaise, rash, pruritus, urticaria.
Frequency Not Known: Isolated face, lip, eyelid edema. Exceptionally, Quincke's edema (rapid swelling of tissues eg, the face, lips, mouth, tongue or throat that may result in breathing difficulty).
Uncommon (<1/100, >1000): Colitis.
Rare (<1/1000, >1/10,000): Dizziness, headache, malaise, rash, pruritus, urticaria.
Frequency Not Known: Isolated face, lip, eyelid edema. Exceptionally, Quincke's edema (rapid swelling of tissues eg, the face, lips, mouth, tongue or throat that may result in breathing difficulty).
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Mechanism of Action: Diosmin + Hesperidin is a phlebotonic drug and a vascular-protecting agent.
The efficacy of Diosmin + Hesperidin is accounted for by its specific action on the principal elements of venous disease.
Diosmin + Hesperidin is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, Diosmin + Hesperidin decreases venous capacitance, venous distensibility and venous emptying time.
Diosmin + Hesperidin protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Diosmin + Hesperidin normalizes capillary permeability and strengthens capillary resistance.
Diosmin + Hesperidin acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Diosmin + Hesperidin on CVD-associated edema.
Double-blind, placebo-controlled studies have demonstrated Diosmin + Hesperidin's efficacy on chronic venous disease. Diosmin + Hesperidin significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
In addition to conventional compression therapy, Diosmin + Hesperidin has been shown to accelerate complete healing of venous leg ulcers.
Diosmin + Hesperidin is highly effective in the treatment of chronic hemorrhoidal disease. It significantly improves subjective symptoms and objective signs eg, anal discomfort, pain, redness, anal discharge, proctitis, tenesmus, pruritus, erythema and bleeding. Diosmin + Hesperidin also significantly reduces the frequency, severity and duration of acute hemorrhoidal attacks and bleeding by chronic treatment.
The efficacy of Diosmin + Hesperidin is accounted for by its specific action on the principal elements of venous disease.
Diosmin + Hesperidin is phlebotonic: It reinforces venous tone by prolonging the activity of parietal noradrenaline. Thus, Diosmin + Hesperidin decreases venous capacitance, venous distensibility and venous emptying time.
Diosmin + Hesperidin protects the microcirculation by fighting the microcirculation-damaging process; it combats venous inflammation by decreasing leukocyte activation, and as a consequence, by inhibiting the release of inflammatory mediators, principally free radicals and prostaglandins. Thus, Diosmin + Hesperidin normalizes capillary permeability and strengthens capillary resistance.
Diosmin + Hesperidin acts on the lymphatic system: It improves lymphatic drainage by increasing lymph flow and lymph oncotic pressure. This action on the lymphatic system associated with a phlebotonic and vasculoprotective effect, explains the activity of Diosmin + Hesperidin on CVD-associated edema.
Double-blind, placebo-controlled studies have demonstrated Diosmin + Hesperidin's efficacy on chronic venous disease. Diosmin + Hesperidin significantly improves disabling symptoms of venous insufficiency which affect everyday active life: Heavy legs, pain, heat sensation, edema, functional impairment and nocturnal cramps.
In addition to conventional compression therapy, Diosmin + Hesperidin has been shown to accelerate complete healing of venous leg ulcers.
Diosmin + Hesperidin is highly effective in the treatment of chronic hemorrhoidal disease. It significantly improves subjective symptoms and objective signs eg, anal discomfort, pain, redness, anal discharge, proctitis, tenesmus, pruritus, erythema and bleeding. Diosmin + Hesperidin also significantly reduces the frequency, severity and duration of acute hemorrhoidal attacks and bleeding by chronic treatment.
MedsGo Class
Anorectal Preparations / Phlebitis & Varicose Preparations
Features
Dosage
450 mg / 50 mg
Ingredients
- Diosmin
- Hesperidin
Packaging
Film-Coated Tablet 30's
Generic Name
Diosmin / Hesperidin
Registration Number
DRP-8865
Classification
Over-The-Counter (OTC)
Reviews
No reviews found
Product Questions
Questions
