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Indications/Uses
Trev-Iron Plus is a well-balanced hematinic formula that provides more than just iron to correct and prevent anemia. It also provides the necessary B-complex vitamins, that help promote the production and maturation of red blood cells and also supply the best form of iron. Adequate doses of Vitamin C and B-complex vitamins in Trev-Iron Plus also provide complementary nutritional benefits.
For Iron deficiency anemia following blood loss, idiopathic hypochromic anemia and hypochromic anemia of pregnancy. Also, in conditions associated with B-complex deficiencies; strenuous physical activity, convalescence, post operative conditions, bums, fractures, alcoholism, lactation, toxic conditions, dietary deficiencies and anemia with or without neurologic complications.
Folic Acid is important in the replication of cells including those of the cells of the bone marrow that are responsible for the formation of blood cells. The maturation of red blood cells specifically requires folate.
Folic Acid is also used to prevent neural tube defects and orofacial clefts in the fetus during pregnancy.
The combination of iron and folate works synergistically to ensure healthy red blood cells.
Ferrous fumarate in Trev- Iron Plus supplies the best form of elemental iron. This iron compound corrects and prevents iron deficiency; and by increasing the hemoglobin content of red blood cell, restores the reddish color of the skin and mucous membranes.
Vitamins C effectively promotes maximum absorption and utilization of elemental iron. It keeps ferric iron from food and other sources in the ferrous form which is more easily absorbed. Vitamin C also strengthens blood vessels and thus helps to correct bleeding which is one cause of anemia.
High dose B-complex vitamins also contribute to formation and maturation of red blood cells. These vitamins increase appetite, improve metabolism, maintain normal functioning of the gastrointestinal tract, and correct nervous disturbances that may co-exist with iron deficiency in anemic patients.
For Iron deficiency anemia following blood loss, idiopathic hypochromic anemia and hypochromic anemia of pregnancy. Also, in conditions associated with B-complex deficiencies; strenuous physical activity, convalescence, post operative conditions, bums, fractures, alcoholism, lactation, toxic conditions, dietary deficiencies and anemia with or without neurologic complications.
Folic Acid is important in the replication of cells including those of the cells of the bone marrow that are responsible for the formation of blood cells. The maturation of red blood cells specifically requires folate.
Folic Acid is also used to prevent neural tube defects and orofacial clefts in the fetus during pregnancy.
The combination of iron and folate works synergistically to ensure healthy red blood cells.
Ferrous fumarate in Trev- Iron Plus supplies the best form of elemental iron. This iron compound corrects and prevents iron deficiency; and by increasing the hemoglobin content of red blood cell, restores the reddish color of the skin and mucous membranes.
Vitamins C effectively promotes maximum absorption and utilization of elemental iron. It keeps ferric iron from food and other sources in the ferrous form which is more easily absorbed. Vitamin C also strengthens blood vessels and thus helps to correct bleeding which is one cause of anemia.
High dose B-complex vitamins also contribute to formation and maturation of red blood cells. These vitamins increase appetite, improve metabolism, maintain normal functioning of the gastrointestinal tract, and correct nervous disturbances that may co-exist with iron deficiency in anemic patients.
Dosage/Direction for Use
Adults: 1 capsule daily to be given preferably after meals.
Overdosage
The amount of iron ingested may give a clue to potential toxicity. The therapeutic dose for iron deficiency anemia is 3-6 mg/kg/day. Toxic effects begin to occur at doses above 20 mg/kg of elemental iron. Ingestion of more than 60 mg/kg of elemental iron is associated with severe toxicity .
Administration
Should be taken with food.
Special Precautions
Concomitant administration of tetracycline and some antacids may decrease the amount of iron absorbed. Taking iron with food reduces the absorption of iron but gastric irritation is however minimized.
Use In Pregnancy & Lactation
Do not use this medicine without a doctor's advice if the patient is pregnant. Some vitamins and minerals can harm an unborn baby if taken in large doses. The patient may need to use a prenatal vitamin specially formulated for pregnant women. The dose needed may also, be different while the patient is nursing. Do not use this medicine without a doctor's advice if the patient is breast-feeding a baby.
Drug Interactions
Avoid taking an antibiotic medicine within 2 hours before or after taking multivitamins with iron. This is especially important if the patient is taking an antibiotic such as ciprofloxacin, levofloxacin norfloxacin, doxycycline, minocycline, tetracycline, and others.
Storage
Store at temperatures not exceeding 30°C. Protect from light.
Action
Pharmacology: Pharmacokinetics: Ferrous Fumarate: Iron is an essential constituent of the body and is necessary for hemoglobin formation and the oxidative processes of living tissues. Iron and iron salts should be given for the treatment or prophylaxis of iron deficiency anemia. Preparations of iron are administered by mouth, by intramuscular or intravenous injection. Soluble ferrous salts are most effective by mouth. Ferrous fumarate is an easily absorbed source of iron for replacement therapy. It is a salt of ferrous iron with an organic acid and is less irritant to the gastro-intestinal tract than salts with inorganic acids.
Vitamin B complex (Vit B1, B6, B12): Thiamine Hydrochloride (Vit B1): A water-soluble vitamin. It is a co-enzyme for carbohydrate metabolism. Pyridoxine Hydrochloride (Vit B6): A water-soluble vitamin. Involved in carbohydrate and fat metabolism, but also important in hemoglobin formation. Cyanocobalamin (Vit B12): This medicine contains cyanocobalamin vitamin B 12, which is used for the treatment of pernicious anemia, and nutritional deficiencies of vitamin B 12 which results in macrocytic anemia.
Folic acid: Folic acid is a member of the vitamin B group. Folic acid is reduced in the body to tetrahydrofolate, which is a co-enzyme for various metabolic processes including the synthesis of purine and pyrimidine nucleotides, and hence in the synthesis of DNA; it is also involved in the formation and utilization of formate. Deficiency of folic acid leads to megaloblastic anemia. Deficiency may result from a diminished intake, as in malnutrition, from malabsorption, or from the concomitant use of anticonvulsants or dihydrofolate reductase inhibitors such as pyrimethamine, trimethoprim, or methotrexate. (Folic acid does not correct folate deficiency due to dihydrofolate reductase inhibitors; calcium folinate is used for this purpose.
Niacinamide: Also known as Nicotinamide. A water-soluble vitamin considered part of the Vitamin B group. Converted to Nicotinamide Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Phosphate in the body, both of which are coenzymes important in electron transfer in respiratory reactions.
Ascorbic Acid: Ascorbic acid, coupled with dehydroascorbic acid to which it is reversibly oxidized, has a variety of functions in cellular oxidation processes. Ascorbic acid is required in several important hydroxylations, including the conversion of proline to hydroxyproline (and thus in collagen formation e.g. for intercellular substances and during wound healing); the formation of the neurotransmitters 5-hydroxytryptamine from tryptophan and noradrenaline from dopamine, and the biosynthesis of carnitine from lysine and methionine. Ascorbic acid appears to have an important role in metal ion metabolism, including the gastrointestinal absorption of iron and its transport between plasma and storage organs. There is evidence that ascorbic acid is required for normal leucocyte functions and that it participates in the detoxification of numerous foreign substances by the hepatic microsomal system. Deficiency of ascorbic acid leads to scurvy, which may be manifested by weakness, fatigue, dyspnoea, aching bones, perifollicular hyperkeratoses, petechia and ecchymosis, swelling and bleeding of the gums, hypochromic anemia and other hematopoietic disorders, together with the reduced residence to infections and impaired wound healing.
Pharmacokinetics: Ferrous Fumarate: In the acid conditions of the gastric contents, ferrous fumarate is dissociated and ferrous ions are liberated. These irons are absorbed in the proximal portion of the duodenum. The ferrous iron absorbed by the mucosal cells of the duodenum is oxidized to the ferric form, and this is bound to a protein to form ferritin. Ferritin in the mucosal cells releases iron into the blood, where it is bound to transferrin and passed into the iron stores - liver, spleen, and bone marrow. These stores are a reserve of iron for the synthesis of hemoglobin, myoglobin, and iron-containing enzymes. Iron is lost from the body through loss of cells in urine, feces, hair, skin, sputum, nails, and mucosal cells, and through blood loss. Ferrous fumarate has the same pattern of absorption and excretion as dietary iron.
Vitamin B-Complex (Vit B1, B6, B12) and Niacinamide: All the actives are water-soluble vitamins. Quantities over the body's requirements are excreted either unchanged or as metabolites, mainly in the urine but to a lesser extent also in the feces.
Folic Acid: Folic acid is absorbed mainly from the proximal part of the small intestine. Dietary folates are stated to have about half the bioavailability of crystalline folic acid. Folate polyglutamates are considered to be deconjugated to monoglutamates during absorption. Folic acid given therapeutically enters the portal circulation largely unchanged, since it is a poor substrate for reduction by dihydrofolate reductases. Folic acid rapidly appears in the blood, where it is extensively bound to plasma proteins. The principal storage site of folate is in the liver; it is also actively concentrated in the CSF. The amounts of folic acid absorbed from normal diets are rapidly distributed in body tissues and about 4 to 5 ug is excreted in the urine daily. There is an enterohepatic circulation for folate. When larger amounts are absorbed, a high proportion is metabolized in the liver to other active forms of folate and a proportion is stored as reduced and methylated folate. Larger amounts of folate are rapidly excreted in the urine. Folic acid is removed by hemodialysis.
Folate is distributed into breast milk.
Ascorbic Acid: Ascorbic acid is well absorbed from the gastrointestinal tract and is widely distributed to all tissues. Body stores of ascorbic acid normally are about 1.5g. The concentration is higher in leukocytes and platelets than in erythrocytes and plasma. Ascorbic acid added to the body's needs, generally amounts above 200mg daily, is rapidly eliminated; unmetabolized ascorbic acid and its inactive metabolic products are chiefly excreted in the urine. The amount of ascorbic acid excreted unchanged in the urine is dose-dependent and may be accompanied by mild diuresis.
Vitamin B complex (Vit B1, B6, B12): Thiamine Hydrochloride (Vit B1): A water-soluble vitamin. It is a co-enzyme for carbohydrate metabolism. Pyridoxine Hydrochloride (Vit B6): A water-soluble vitamin. Involved in carbohydrate and fat metabolism, but also important in hemoglobin formation. Cyanocobalamin (Vit B12): This medicine contains cyanocobalamin vitamin B 12, which is used for the treatment of pernicious anemia, and nutritional deficiencies of vitamin B 12 which results in macrocytic anemia.
Folic acid: Folic acid is a member of the vitamin B group. Folic acid is reduced in the body to tetrahydrofolate, which is a co-enzyme for various metabolic processes including the synthesis of purine and pyrimidine nucleotides, and hence in the synthesis of DNA; it is also involved in the formation and utilization of formate. Deficiency of folic acid leads to megaloblastic anemia. Deficiency may result from a diminished intake, as in malnutrition, from malabsorption, or from the concomitant use of anticonvulsants or dihydrofolate reductase inhibitors such as pyrimethamine, trimethoprim, or methotrexate. (Folic acid does not correct folate deficiency due to dihydrofolate reductase inhibitors; calcium folinate is used for this purpose.
Niacinamide: Also known as Nicotinamide. A water-soluble vitamin considered part of the Vitamin B group. Converted to Nicotinamide Adenine Dinucleotide and Nicotinamide Adenine Dinucleotide Phosphate in the body, both of which are coenzymes important in electron transfer in respiratory reactions.
Ascorbic Acid: Ascorbic acid, coupled with dehydroascorbic acid to which it is reversibly oxidized, has a variety of functions in cellular oxidation processes. Ascorbic acid is required in several important hydroxylations, including the conversion of proline to hydroxyproline (and thus in collagen formation e.g. for intercellular substances and during wound healing); the formation of the neurotransmitters 5-hydroxytryptamine from tryptophan and noradrenaline from dopamine, and the biosynthesis of carnitine from lysine and methionine. Ascorbic acid appears to have an important role in metal ion metabolism, including the gastrointestinal absorption of iron and its transport between plasma and storage organs. There is evidence that ascorbic acid is required for normal leucocyte functions and that it participates in the detoxification of numerous foreign substances by the hepatic microsomal system. Deficiency of ascorbic acid leads to scurvy, which may be manifested by weakness, fatigue, dyspnoea, aching bones, perifollicular hyperkeratoses, petechia and ecchymosis, swelling and bleeding of the gums, hypochromic anemia and other hematopoietic disorders, together with the reduced residence to infections and impaired wound healing.
Pharmacokinetics: Ferrous Fumarate: In the acid conditions of the gastric contents, ferrous fumarate is dissociated and ferrous ions are liberated. These irons are absorbed in the proximal portion of the duodenum. The ferrous iron absorbed by the mucosal cells of the duodenum is oxidized to the ferric form, and this is bound to a protein to form ferritin. Ferritin in the mucosal cells releases iron into the blood, where it is bound to transferrin and passed into the iron stores - liver, spleen, and bone marrow. These stores are a reserve of iron for the synthesis of hemoglobin, myoglobin, and iron-containing enzymes. Iron is lost from the body through loss of cells in urine, feces, hair, skin, sputum, nails, and mucosal cells, and through blood loss. Ferrous fumarate has the same pattern of absorption and excretion as dietary iron.
Vitamin B-Complex (Vit B1, B6, B12) and Niacinamide: All the actives are water-soluble vitamins. Quantities over the body's requirements are excreted either unchanged or as metabolites, mainly in the urine but to a lesser extent also in the feces.
Folic Acid: Folic acid is absorbed mainly from the proximal part of the small intestine. Dietary folates are stated to have about half the bioavailability of crystalline folic acid. Folate polyglutamates are considered to be deconjugated to monoglutamates during absorption. Folic acid given therapeutically enters the portal circulation largely unchanged, since it is a poor substrate for reduction by dihydrofolate reductases. Folic acid rapidly appears in the blood, where it is extensively bound to plasma proteins. The principal storage site of folate is in the liver; it is also actively concentrated in the CSF. The amounts of folic acid absorbed from normal diets are rapidly distributed in body tissues and about 4 to 5 ug is excreted in the urine daily. There is an enterohepatic circulation for folate. When larger amounts are absorbed, a high proportion is metabolized in the liver to other active forms of folate and a proportion is stored as reduced and methylated folate. Larger amounts of folate are rapidly excreted in the urine. Folic acid is removed by hemodialysis.
Folate is distributed into breast milk.
Ascorbic Acid: Ascorbic acid is well absorbed from the gastrointestinal tract and is widely distributed to all tissues. Body stores of ascorbic acid normally are about 1.5g. The concentration is higher in leukocytes and platelets than in erythrocytes and plasma. Ascorbic acid added to the body's needs, generally amounts above 200mg daily, is rapidly eliminated; unmetabolized ascorbic acid and its inactive metabolic products are chiefly excreted in the urine. The amount of ascorbic acid excreted unchanged in the urine is dose-dependent and may be accompanied by mild diuresis.
MedsGo Class
Vitamins & Minerals (Pre & Post Natal) / Antianemics
Features
Brand
Trev-Iron Plus
Full Details
Drug Ingredients
- Iron
- Multivitamins
Drug Packaging
Capsule 100's
Generic Name
Multivitamins / Iron
Dosage Form
Capsule
Registration Number
DR-XY30912
Drug Classification
Prescription Drug (RX)