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EVAPRIN-A2731I

EVAPRINE Isoxsuprine Hydrochloride 10mg Tablet 1's

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Description

Indications/Uses

Isoxsuprine is a vasodilator that also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular and uterine smooth muscle and its vasodilating action is greater on the arteries supplying skeletal muscles than on those supplying skin. Isoxsuprine also produces positive inotropic and chronotropic effects.
Isoxsuprine hydrochloride has been used to arrest premature labour, but drugs with a more selective action are now preferred. It has also been given in the treatment of cerebral and peripheral vascular disease.

Dosage/Direction for Use

Tab: For use as a vasodilator, isoxsuprine hydrochloride is given by mouth in doses of 10 to 20 mg 3 or 4 times daily.
Inj: To arrest premature labour, isoxsuprine hydrochloride is given initially by intravenous infusion in doses of 200 to 500 micrograms/minute, adjusted according to the patient's response, until control is achieved. It is now common practice to give beta agonists by syringe pump when using them to delay premature labour. Maternal blood pressure and hydration, and maternal and fetal heart rates should be monitored during the infusion. Once labour has been arrested intramuscular injections of 10 mg are given every 3 to 8 hours for several days. Prophylaxis may be continued by mouth with 30 to 90 mg daily in divided doses. The resinate has also been used similarly.

Contraindications

Recent arterial hemorrhage; Heart disease; Premature placental separation; Severe anemia; Infection; Hypotension, tachycardia, or immediate post-partum.

Warnings

Maternal and fetal HR should be monitored during the infusion because of maternal hypertension and pulmonary edema and fetal tachycardia.

Special Precautions

It should not be given immediately post partum, nor should it be used for premature labour if there is infection. In women being treated for premature labour, the risk of pulmonary edema means that extreme caution is required.

Adverse Reactions

Isoxsuprine may cause transient flushing, hypotension, tachycardia, rashes, and gastrointestinal disturbances. Maternal pulmonary edema and fetal tachycardia have been reported after intravenous use in premature labour.

Drug Interactions

Vasodilators such as isoxsuprine may enhance the antihypertensive effect of diazoxide.

Storage

Store at temperatures not exceeding 30°C. Protect from light.
Shelf life: 36 months

MedsGo Class

Peripheral Vasodilators & Cerebral Activators / Drugs Acting on the Uterus

Features

Brand
EVAPRINE
GTIN
4806525175270
Full Details
Dosage Strength
10mg
Drug Ingredients
  • Isoxsuprine Hydrochloride
Drug Packaging
Tablet 1's
Generic Name
Isoxsuprine Hydrochloride
Dosage Form
Tablet
Drug Classification
Prescription Drug (RX)
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