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Indications/Uses
Isoxsuprine hydrochloride has been used to arrest premature labour. It has also been given in the treatment of cerebral and peripheral vascular disease.
Dosage/Direction for Use
Initial dose of 10 mg to 20 mg three to four times daily. Or as prescribed by the physician.
Administration
May be taken with or without food: May be taken w/ meals, milk or antacids to minimise GI discomfort.
Contraindications
Recent arterial hemorrhage.
Special Precautions
lsoxsuprine is contra-indicated after recent arterial haemorrhage. It should not be given immediately post partum, nor should it be used for premature labour if there is infection. In women being treated for premature labour, the risk of pulmonary oedema means that extreme caution is required and the precautions and risk factors discussed under Salbutamol sulfate.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacodynamics: Mechanism of Action: Isoxsuprine is a vasodilator which also stimulates beta-adrenergic receptors. It causes direct relaxation of vascular and uterine smooth muscle and its vasodilating action is greater on the arteries supplying skeletal muscle than on those supplying skin. Isoxsuprine also produces positive inotropic and chronotropic effects.
Pharmacokinetics: Isoxsuprine hydrochloride is well absorbed from the gastrointestinal tract. The peak plasma concentration occurs about 1 hour after administration by mouth. A plasma half-life of 1.5 hours has been reported. Isoxsuprine is excreted in the urine mainly as conjugates.
Pharmacokinetics: Isoxsuprine hydrochloride is well absorbed from the gastrointestinal tract. The peak plasma concentration occurs about 1 hour after administration by mouth. A plasma half-life of 1.5 hours has been reported. Isoxsuprine is excreted in the urine mainly as conjugates.
MedsGo Class
Peripheral Vasodilators & Cerebral Activators / Drugs Acting on the Uterus
Features
Brand
Duvaprine
Full Details
Dosage Strength
10 mg
Drug Ingredients
- Isoxsuprine
Drug Packaging
Film-Coated Tablet 40's
Generic Name
Isoxsuprine Hydrochloride
Dosage Form
Film-Coated Tablet
Registration Number
DRP-3597
Drug Classification
Prescription Drug (RX)