ZUNAMYN Sultamicillin Tosylate 750mg Film-Coated Tablet 50's
RXDRUG-DRP-5379
Discreet Packaging
FDA-registered Products
FDA-licensed Pharmacies
Indications/Uses
Sultamicillin is used in the treatment of infections where β-lactamase producing organisms including uncomplicated gonorrhea, otitis media and respiratory tract and urinary tract infections.
Dosage/Direction for Use
Usual adult dose: One 375 mg FCT every 12 hours.
For more severe infections: One 750 mg FCT every 12 hours.
For severe soft tissue infections: 2.25 g or one 750 mg FCT TID.
For more severe infections: One 750 mg FCT every 12 hours.
For severe soft tissue infections: 2.25 g or one 750 mg FCT TID.
Administration
May be taken with or without food.
Contraindications
The use of this product is contraindicated in individuals with history of an allergic reaction to any penicillins.
Special Precautions
As with antibiotic preparation, constant observation of signs of over-growth of nonsusceptible organisms, including fungi is essential. Should be discontinued and/or appropriate therapy instituted.
It is advisable to check periodically for organ system dysfunction during prolonged therapy, this includes renal, hepatic and hematopoietic systems.
Use in Pregnancy: Animal reproduction studies have revealed no evidence of impaired fertility or harm to the fetus due to sultamicillin is administered to nursing woman.
It is advisable to check periodically for organ system dysfunction during prolonged therapy, this includes renal, hepatic and hematopoietic systems.
Use in Pregnancy: Animal reproduction studies have revealed no evidence of impaired fertility or harm to the fetus due to sultamicillin is administered to nursing woman.
Use In Pregnancy & Lactation
Use in Pregnancy: Animal reproduction studies have revealed no evidence of impaired fertility or harm to the fetus due to sultamicillin is administered to nursing woman.
Adverse Reactions
Sultamicillin is generally well tolerated. The majorities of side effects observed were of mild or moderate severity and were normally tolerated with continued treatment.
Gastrointestinal: the most frequent observed side effects was diarrhea/loose stool. Nausea, vomiting, epigastric distress and abdominal pain/cramps have been observed. As with other ampicillin-class antibiotics, enterocolitis and pseudomembranous colitis rarely may occur.
Skin/Skin Structures: rash and itching were infrequently observed.
Miscellaneous: drowsiness/sedation, fatigue and headache have been rarely observed.
Gastrointestinal: the most frequent observed side effects was diarrhea/loose stool. Nausea, vomiting, epigastric distress and abdominal pain/cramps have been observed. As with other ampicillin-class antibiotics, enterocolitis and pseudomembranous colitis rarely may occur.
Skin/Skin Structures: rash and itching were infrequently observed.
Miscellaneous: drowsiness/sedation, fatigue and headache have been rarely observed.
Drug Interactions
Probenecid decreases the renal tubular secretion and sulbactam. Concurrent use of probenecid with Sultamicillin may result in increased and prolonged blood levels of ampicillin and sulbactam. The concurrent administration of allopurinol and ampicillin increases substantially the incidence of rashes in patients receiving both drugs as compared to patients receiving both drug as compared to patients receiving ampicillin alone.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacokinetics: Following oral administration in humans, sultamicillin is hydrolyzed during absorption to provide sulbactam and ampicillin. Elimination half-lives 0.75 and 1 hour for sulbactam and ampicillin respectively in healthy volunteers, with 50-75% of each agent excreted in the urine unchanged. Elimination half-life are increased in the elderly and in patients with renal dysfunction. Probenecid decreases the renal tubular secretion of both ampicillin and sulbactam. Concurrent use of probenecid with sultamicillin results in increased and prolonged blood levels.
Microbiology: Sultamicillin is effective against wide range of gram-positive bacteria including: Staphylococcus aureus and epidermis (including penicillin-resistant and some methicillin resistant strains); Branhamelia catarrhalis; anaerobes including Bacteroides fragilis and related species, Escherichia coli; Klebsiella species, Proteus species, (both indole-positive and indole-negative); Enterobacter species; Morganella morganii; Citrobacter species; Neisseria meningitides and Neisseria gonorrhea.
Microbiology: Sultamicillin is effective against wide range of gram-positive bacteria including: Staphylococcus aureus and epidermis (including penicillin-resistant and some methicillin resistant strains); Branhamelia catarrhalis; anaerobes including Bacteroides fragilis and related species, Escherichia coli; Klebsiella species, Proteus species, (both indole-positive and indole-negative); Enterobacter species; Morganella morganii; Citrobacter species; Neisseria meningitides and Neisseria gonorrhea.
MedsGo Class
Penicillins
Features
Brand
ZUNAMYN
Full Details
Dosage Strength
750mg
Drug Ingredients
- Sultamicillin
Drug Packaging
Film-Coated Tablet 50's
Generic Name
Sultamicillin Tosylate
Dosage Form
Film-Coated Tablet
Registration Number
DRP-5379
Drug Classification
Prescription Drug (RX)
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