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Indications/Uses
Azithromycin is indicated in upper respiratory tract infections, including pharyngitis, tonsillitis, sinusitis, otitis media, lower respiratory tract infections including bronchitis, pneumonia; skin and soft tissue infections.
Azithromycin is also indicated in the treatment of uncomplicated genital infections due to Chlamydia trachomatis and uncomplicated gonorrhea from sexually transmitted diseases of men and women.
Azithromycin may also be used for prophylaxis in at-risk patients unable to take penicillins.
Azithromycin is also indicated in the treatment of uncomplicated genital infections due to Chlamydia trachomatis and uncomplicated gonorrhea from sexually transmitted diseases of men and women.
Azithromycin may also be used for prophylaxis in at-risk patients unable to take penicillins.
Dosage/Direction for Use
Upper respiratory tract infections, including sinusitis, pharyngitis, tonsillitis, otitis media, and lower respiratory tract infections including bronchitis, pneumonia, skin and soft tissue infections: The usual adult dose is 500 mg of Azithromycin (as dihydrate) once daily for 3 days, 1 dose/tablet before meals or 2 hours after meals.
An alternative to this dosage schedule is taking 2 capsules of Azithromycin 250 mg given as a single dose for the first day, followed by 1 capsule of Azithromycin 250 mg daily in the next 4 days.
Sexually transmitted diseases caused by Chlamydia trachomatis: The prescribed dosage is 1000 mg of Azithromycin (as dihydrate). 4 capsules of Azithromycin 250 mg or 2 tablets of Azithromycin 500 mg given as a single dose.
The single dose of 2 g maybe given for uncomplicated gonorrhea (4 tablets of Azithromycin 500 mg tablets).
OR AS DIRECTED BY THE PHYSICIAN.
An alternative to this dosage schedule is taking 2 capsules of Azithromycin 250 mg given as a single dose for the first day, followed by 1 capsule of Azithromycin 250 mg daily in the next 4 days.
Sexually transmitted diseases caused by Chlamydia trachomatis: The prescribed dosage is 1000 mg of Azithromycin (as dihydrate). 4 capsules of Azithromycin 250 mg or 2 tablets of Azithromycin 500 mg given as a single dose.
The single dose of 2 g maybe given for uncomplicated gonorrhea (4 tablets of Azithromycin 500 mg tablets).
OR AS DIRECTED BY THE PHYSICIAN.
Administration
Should be taken on an empty stomach: Take 1 hr before or 2 hr after meals.
Contraindications
Azithromycin is contraindicated in patients with known hypersensitivity to Azithromycin and with hepatic disease.
Special Precautions
Azithromycin absorption is reduced by 50% in the presence of food in the stomach. It should therefore be taken 1 hour before or 2 hours after meals.
Macrolides have been known to increase the plasma concentration of digoxin and cyclosporin. Therefore, if co-administration is necessary, caution should be exercised and serum level of digoxin and cylcosporin should be checked. Precaution should be taken in patients with hepatic and severe renal impairment. No adverse effects on the fetus during pregnancy is reported. However, caution should be exercised as with other drugs.
Macrolides have been known to increase the plasma concentration of digoxin and cyclosporin. Therefore, if co-administration is necessary, caution should be exercised and serum level of digoxin and cylcosporin should be checked. Precaution should be taken in patients with hepatic and severe renal impairment. No adverse effects on the fetus during pregnancy is reported. However, caution should be exercised as with other drugs.
Adverse Reactions
Azithromycin is well tolerated with a low incidence of adverse effects which are mild to moderate in nature and of gastrointestinal in origin (e.g. nausea, abdominal discomfort, vomiting, flatulence and diarrhea). Allergic reactions, such as rash may occur in hypersensitive patients.
Drug Interactions
Azithromycin absorption is reduced in the presence of antacid. So, Azithromycin should be administered 1 hour before or 2 hours after taking an antacid.
Storage
Store at temperatures not exceeding 30°C.
MedsGo Class
Macrolides
Features
Brand
Zithromin
Full Details
Dosage Strength
500mg
Drug Ingredients
- Azithromycin
Drug Packaging
Film-Coated Tablet 1's
Generic Name
Azithromycin Dihydrate
Dosage Form
Film-Coated Tablet
Registration Number
DRP-3637-02
Drug Classification
Prescription Drug (RX)