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Indications/Uses
Treatment of severe gm -ve infection & other susceptible bacteria; neutropenic patients; cystic fibrosis; otitis media; skin infection; surgical infection prophylaxis; UTI; bone & joint infections; gynecological infection including postpartum endometritis & pelvic inflammatory disease (PID); peritonitis; septicemia.
Dosage/Direction for Use
Adult Serious or complicated infections 200-300 mg/kg IV daily in divided doses. Usual dose: 4 g 6-8 hrly. Life-threatening infections due to Klebsiella spp or Pseudomonas ≤16 g daily. Max: 24 g/day. Mild or uncomplicated infections 100-150 mg/kg/day. Usual dose: 2 g 6-8 hrly or 4 g 12 hrly IV. Prophylaxis of surgical infection 2 g pre-op or when the umbilical cord is clamped in CS followed by at least 2 doses of 2 g intervals of 4-6 hr w/in 24 hr of the procedure. IV Childn 1 mth-12 yr 100-300 mg/kg/day in 3-4 divided doses. Neonate >7 days or >2 kg 300 mg/kg/day in 3-4 divided doses, <7 days or <2 kg 150 mg/kg/day in 3 divided doses. May be administered by slow IV inj over 3-5 min; IV infusion over 20-40 min. Renal insufficiency CrCl 20-80 mL/min 12 g/1.5 g/day in divided doses or 4 g/500 mg 8 hrly, <20 mL/min 8 g/1 g/day in divided doses or 4 g/500 mg 12 hrly.
Contraindications
History of allergic reactions to penicillins, cephalosporins, β-lactamase inhibitors.
Special Precautions
Bleeding, clotting time; superinfection; organ system function assessment. Fever & rash in cystic fibrosis patients; patients w/ syphilis. Neutropenia & leukopenia may occur in prolonged treatment. Possibility of hypokalemia. Pregnancy & lactation.
Adverse Reactions
Nausea; indigestion, vomiting, diarrhea or constipation; rash, itchy or red skin, urticaria; sleeping difficulty, headache or dizziness; superinfection.
Drug Interactions
Anticoagulants, probenecid, vecuronium, aminoglycosides, methotrexate.
MedsGo Class
Penicillins
Features
Brand
VIGOCID
Full Details
Dosage Strength
2g / 250 mg
Drug Ingredients
- Piperacillin
- Tazobactam
Drug Packaging
Lyophilized Powder for IV Injection 20mL 1's
Generic Name
Piperacillin Sodium / Tazobactam Sodium
Dosage Form
Lyophilized Powder for IV Injection
Registration Number
DR-XY32027
Drug Classification
Prescription Drug (RX)