TYPHECLOR Chloramphenicol 125mg / 5mL Suspension 60mL

Indications / Uses

TYPHECLOR Chloramphenicol 125mg / 5mL Suspension is used for treating serious infections caused by susceptible bacteria, particularly when other appropriate antimicrobial agents are ineffective. Its use is generally reserved for severe infections like typhoid fever and other types of salmonellosis, bacterial meningitis, and rickettsial infections. This medication acts by inhibiting bacterial protein synthesis, which prevents the growth and replication of the bacteria. It should never be given for minor infections such as colds, flu, or simple sore throats.

Formulation / Ingredients

TYPHECLOR Chloramphenicol 125mg / 5mL Suspension contains: Chloramphenicol Palmitate equivalent to Chloramphenicol 125mg / 5mL

Side Effects

TYPHECLOR Chloramphenicol 125mg / 5mL Suspension common side effects include gastrointestinal issues such as nausea, vomiting, diarrhea, and a loss of appetite. More serious and potentially fatal blood disorders like aplastic anemia, hypoplastic anemia, thrombocytopenia, and granulocytopenia are known to occur during or following both short-term and prolonged use. Other possible effects include oral discomfort like glossitis and stomatitis, headache, mental confusion, and rarely, damage to the optic nerve resulting in visual disturbances.

Directions and Dosage

• Dosage for Adults and Children: 50 mg per kg of body weight daily, divided into doses given every 6 hours.
• Dosage for Severe Infections: Up to 100 mg per kg of body weight daily may be given, but this higher dosage should be quickly reduced to the usual dose as soon as the infection is controlled.
• Dosage for Full-term Infants over 2 weeks: Up to 50 mg per kg of body weight daily in 4 divided doses.
• Dosage for Premature and Full-term Neonates: 25 mg per kg of body weight daily.

Dosing may need adjustment in individuals with impaired hepatic function or severe renal impairment. Treatment duration for rickettsial diseases should continue for 4 days after the return to normal temperature, and 8 to 10 days for typhoid fever.

Contraindications

The preparation should not be used by individuals with a history of an allergic or toxic reaction to the active ingredient. It is not suitable for treating trivial infections or for use as a prophylactic agent to prevent an infection. Use is also restricted for individuals with pre-existing bone-marrow depression or blood disorders.

Use in Pregnancy and Lactation

Use during the later stages of pregnancy has been linked to severe adverse effects in newborn infants, including a risk of cardiovascular collapse. The active substance is excreted into human milk and may cause adverse effects in a nursing child, such as intestinal gas and vomiting.

Special Precautions

• Use should be avoided for minor infections or as a preventative measure.
• Repeated courses of treatment or prolonged administration should be avoided.
• Patients should be closely monitored with routine blood examinations throughout the course of treatment.
• Administration should be avoided alongside other preparations known to suppress bone marrow function.
• Infants, especially newborns, are at risk for a serious toxic effect known as "gray syndrome."

Is it safe to take it with other medications?

The active substance can interfere with the metabolism of other preparations, potentially increasing their plasma levels and effects, such as with certain blood thinners or diabetes medications. Conversely, some preparations can decrease the plasma levels of this medication, potentially making it less effective.

How should I store it?

Keep the suspension in a closed container. Store it at room temperature, ensuring the temperature does not exceed 30°C.

Used For

Bacterial Infections

Age

From 14 days