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Indications/Uses
FC tab: Treatment of susceptible infections such as bone and joint infections, bronchitis (and other lower respiratory tract infections), gonorrhea, meningitis, otitis media, peritonitid, pharyngitis, sinusitis, skin and soft tissue infections, urinary tract infection and for surgical infection prophylaxis.
Powd for Inj: Used in the treatment of susceptible infections. These have included bone and joint infections, bronchitis, gonorrhoea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections, and urinary tract infections.
Powd for Inj: Used in the treatment of susceptible infections. These have included bone and joint infections, bronchitis, gonorrhoea, meningitis, otitis media, peritonitis, pharyngitis, sinusitis, skin infections, and urinary tract infections.
Dosage/Direction for Use
Powd for Inj: Cefuroxime Sodium may be given by deep intramuscular injection, by slow intravenous injection over 3 to 5 minutes, or by intravenous infusion.
For adult: 750 mg every 8 hours. Severe infection 1.5g IV every 6 to 8 hours for 5 to 10 days.
Infant and children: 30-60 mg/kg/day, dose may be increased to 100 mg/kg/day in 3-4 divided doses.
Neonates: Same total daily dose as children but in 2-3 divided doses.
Or as prescribed by the physician.
For adult: 750 mg every 8 hours. Severe infection 1.5g IV every 6 to 8 hours for 5 to 10 days.
Infant and children: 30-60 mg/kg/day, dose may be increased to 100 mg/kg/day in 3-4 divided doses.
Neonates: Same total daily dose as children but in 2-3 divided doses.
Or as prescribed by the physician.
Administration
May be taken with or without food.
Contraindications
Should not be given to patients who are sensitive to it or to other cephalosporins.
Special Precautions
It should not be given to patient who are hypertensive to it or to other cephalosporin. About 10% of penicillin-sensitive patients may also be allergic to cephalosporins although the true incidence is uncertain; Great care should be taken if it is to be given to such patients. Care is also necessary in patients with a history of allergy. It should be given with caution to patients with renal impairment; a dosage of reduction may be necessary. Renal and haematological status should be monitored especially drug prolonged and high dose therapy.
Adverse Reactions
Gastrointestinal disturbances, including diarrhoea, nausea, and vomiting have occured in some patients receiving cefuroxime. There have been rare reports of erythema multiforme, Stevens-Johnson syndrome, and toxic epidermal necrolysis.
Drug Interactions
Probenecid reduces the renal clearance of cefuroxime.
Caution For Usage
Direction for Reconstitution: For 750 mg: IM Use: Dissolve the content in 3 mL of Sterile Water for Injection.
IV Use: Dissolve the content in 8.3 mL of Sterile Water for Injection.
For 1.5 g: IV Use: Dissolve the content in 16 mL Sterile Water for Injection.
IV Use: Dissolve the content in 8.3 mL of Sterile Water for Injection.
For 1.5 g: IV Use: Dissolve the content in 16 mL Sterile Water for Injection.
Storage
Store at temperatures not exceeding 30°C.
Action
Pharmacology: Pharmacokinetics: Cefuroxime is widely distributed in the body including pleural fluid, sputum, bone, synovial fluid, and aqueous humour, but only achieves therapeutic concentrations in the CSF when the meninges are inflamed. It crosses the placenta and has been detected in breast milk. It is excreted unchanged, by glomerular titration and renal tubular secretion, and high concentrations are achieved in the urine. Following injection most of a dose of cefuroxime is excreted within 24 hours, the majority within 6 hours. Probenecid competes for renal tubular secretion with cefuroxime resulting in higher and more prolonged plasma concentrations of cefuroxirne. Small amounts of cefuroxime are excreted in bile. Plasma concentrations are reduced by dialysis.
MedsGo Class
Cephalosporins
Features
Dosage
500mg
Ingredients
- Cefuroxime
Packaging
Film-Coated Tablet 10's
Generic Name
Cefuroxime Axetil
Registration Number
DRP-8203
Classification
Prescription Drug (RX)
Reviews
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